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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Cash flows from operating activities      
Net income $ 1,503.1 $ 823.4 $ 1,046.9
Adjustments to reconcile net income to cash provided by operating activities:      
Depreciation and amortization 134.8 107.2 89.3
Non-cash operating lease cost 28.5 28.2 25.3
Stock-based compensation (Notes 2 and 14) 109.3 92.6 81.3
Inventory write off (Note 2) 0.0 0.0 73.1
Impairment charges (Note 4) 0.0 0.0 40.6
Change in fair value of contingent consideration liabilities, net (Note 11) (124.1) 13.6 (6.1)
Deferred income taxes (41.4) (49.4) 12.1
Purchased in-process research and development (Note 4) 0.0 0.0 24.0
Other (23.4) (3.5) (2.8)
Changes in operating assets and liabilities:      
Accounts and other receivables, net (91.1) 41.9 (88.0)
Inventories 19.0 (120.6) (105.4)
Prepaid expenses and other current assets 7.9 (28.5) (6.8)
Accounts payable and accrued liabilities 195.2 (84.5) 116.5
Litigation settlement accrual (29.2) 270.5 (180.0)
Income taxes 62.0 (52.9) 43.2
Other (18.5) 16.3 19.7
Net cash provided by operating activities 1,732.1 1,054.3 1,182.9
Cash flows from investing activities      
Capital expenditures (325.8) (407.0) (254.4)
Purchases of held-to-maturity investments (Note 7) (250.0) (162.0) (130.2)
Proceeds from sales and maturities of held-to-maturity investments (Note 7) 138.0 212.2 50.0
Purchases of available-for-sale investments (Note 7) (1,629.3) (689.7) (437.9)
Proceeds from sales and maturities of available-for-sale investments (Note 7) 391.2 564.8 359.9
Acquisition (Note 8) 0.0 0.0 (100.2)
Payment for acquisition option (13.1) (10.0) (35.0)
Issuances of notes receivable (5.1) (27.0) (12.9)
Collections of notes receivable 20.0 0.0 0.0
Investments in intangible assets and in-process research and development (4.0) (0.3) (24.0)
Other (44.4) (12.1) (11.1)
Net cash used in investing activities (1,722.5) (531.1) (595.8)
Cash flows from financing activities      
Proceeds from issuance of debt 5.2 16.2 18.9
Payments on debt and finance lease obligations (7.0) (17.0) (28.9)
Purchases of treasury stock (512.8) (625.4) (263.3)
Proceeds from stock plans 158.6 140.5 160.5
Other (0.3) (1.2) (2.8)
Net cash used in financing activities (356.3) (486.9) (115.6)
Effect of currency exchange rate changes on cash, cash equivalents, and restricted cash 13.9 (20.5) (3.0)
Net (decrease) increase in cash, cash equivalents, and restricted cash (332.8) 15.8 468.5
Cash, cash equivalents, and restricted cash at beginning of year 1,200.2 1,184.4 715.9
Cash, cash equivalents, and restricted cash at end of year $ 867.4 $ 1,200.2 $ 1,184.4