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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities      
Net income $ 1,521.9 $ 1,503.1 $ 823.4
Adjustments to reconcile net income to cash provided by operating activities:      
Depreciation and amortization 139.6 134.8 107.2
Non-cash operating lease cost 27.2 28.5 28.2
Stock-based compensation (Notes 2 and 14) 126.8 109.3 92.6
Impairment charges (Note 4) 55.1 4.0 0.0
Change in fair value of contingent consideration liabilities, net (Note 11) (35.8) (124.1) 13.6
Loss (gain) on investments, net 51.5 (36.8) (21.2)
Deferred income taxes (254.5) (41.4) (49.4)
Other 7.8 9.4 17.7
Changes in operating assets and liabilities:      
Accounts and other receivables, net (84.1) (91.1) 41.9
Inventories (213.4) 19.0 (120.6)
Prepaid expenses and other current assets 0.1 7.9 (28.5)
Accounts payable and accrued liabilities (21.4) 195.2 (84.5)
Litigation settlement accrual (45.0) (29.2) 270.5
Income taxes (5.6) 62.0 (52.9)
Other (52.0) (18.5) 16.3
Net cash provided by operating activities 1,218.2 1,732.1 1,054.3
Cash flows from investing activities      
Capital expenditures (244.6) (325.8) (407.0)
Purchases of held-to-maturity investments (Note 7) (353.5) (250.0) (162.0)
Proceeds from sales and maturities of held-to-maturity investments (Note 7) 419.5 138.0 212.2
Purchases of available-for-sale investments (Note 7) (315.8) (1,629.3) (689.7)
Proceeds from sales and maturities of available-for-sale investments (Note 7) 939.6 391.2 564.8
Payment for acquisition option (Note 8) (109.6) (13.1) (10.0)
Issuances of notes receivable (52.3) (5.1) (27.0)
Collections of notes receivable 18.0 20.0 0.0
Investments in intangible assets (20.2) (4.0) (0.3)
Other (28.8) (44.4) (12.1)
Net cash provided by (used in) investing activities 252.3 (1,722.5) (531.1)
Cash flows from financing activities      
Proceeds from issuance of debt 0.0 5.2 16.2
Payments on debt and finance lease obligations (0.2) (7.0) (17.0)
Purchases of treasury stock (1,727.1) (512.8) (625.4)
Proceeds from stock plans 146.4 158.6 140.5
Other (3.6) (0.3) (1.2)
Net cash used in financing activities (1,584.5) (356.3) (486.9)
Effect of currency exchange rate changes on cash, cash equivalents, and restricted cash 19.2 13.9 (20.5)
Net (decrease) increase in cash, cash equivalents, and restricted cash (94.8) (332.8) 15.8
Cash, cash equivalents, and restricted cash at beginning of year 867.4 1,200.2 1,184.4
Cash, cash equivalents, and restricted cash at end of year $ 772.6 $ 867.4 $ 1,200.2