Exhibit 21.1
The following is a list of subsidiaries of Edwards Lifesciences Corporation, omitting subsidiaries which, considered in the aggregate as a single subsidiary, would not constitute a significant subsidiary as of December 31, 2022:
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| Legal Entity | | State of Incorporation/ Formation | | Country of Incorporation/ Formation |
| Edwards Lifesciences LLC | | Delaware | | U.S. |
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| Edwards Lifesciences (U.S.) Inc. | | Delaware | | U.S. |
| Edwards Lifesciences (Japan) Limited | | | | Japan |
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