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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities      
Net income $ 1,399.4 $ 1,521.9 $ 1,503.1
Adjustments to reconcile net income to net cash provided by operating activities:      
Depreciation and amortization 144.9 139.6 134.8
Non-cash operating lease cost 28.2 27.2 28.5
Stock-based compensation (Notes 2 and 15) 139.4 126.8 109.3
Impairment charges (Note 4) 0.0 55.1 4.0
Change in fair value of contingent consideration liabilities (Note 12) (26.2) (35.8) (124.1)
Loss (gain) on investments, net 0.1 51.5 (36.8)
Deferred income taxes (272.1) (254.5) (41.4)
Other 8.4 7.8 9.4
Changes in operating assets and liabilities:      
Accounts and other receivables, net (141.2) (84.1) (91.1)
Inventories (289.0) (213.4) 19.0
Prepaid expenses and other current assets (81.8) 0.1 7.9
Accounts payable and accrued liabilities 146.0 (21.4) 195.2
Intellectual property agreement accrual (33.0) (45.0) (29.2)
Income taxes (5.8) (5.6) 62.0
Long-term prepaid royalties (Note 3) (109.9) 0.0 0.0
Other (11.6) (52.0) (18.5)
Net cash provided by operating activities 895.8 1,218.2 1,732.1
Cash flows from investing activities      
Capital expenditures (253.0) (244.6) (325.8)
Purchases of held-to-maturity investments (Note 7) (66.4) (353.5) (250.0)
Proceeds from sales and maturities of held-to-maturity investments (Note 7) 97.9 419.5 138.0
Purchases of available-for-sale investments (Note 7) (9.1) (315.8) (1,629.3)
Proceeds from sales and maturities of available-for-sale investments (Note 7) 617.9 939.6 391.2
Business combination, net of cash (Note 9) (95.2) 0.0 0.0
Payments for acquisition options (Note 8) (30.0) (109.6) (13.1)
Issuances of notes receivable (62.5) (52.3) (5.1)
Collections of notes receivable 0.0 18.0 20.0
Investments in intangible assets (13.3) (20.2) (4.0)
Other (12.5) (28.8) (44.4)
Net cash provided by (used in) investing activities 173.8 252.3 (1,722.5)
Cash flows from financing activities      
Proceeds from issuance of debt 0.0 0.0 5.2
Payments on debt and finance lease obligations (0.3) (0.2) (7.0)
Purchases of treasury stock (879.6) (1,727.1) (512.8)
Proceeds from stock plans 169.9 146.4 158.6
Other (1.0) (3.6) (0.3)
Net cash used in financing activities (711.0) (1,584.5) (356.3)
Effect of currency exchange rate changes on cash, cash equivalents, and restricted cash 16.8 19.2 13.9
Net increase (decrease) in cash, cash equivalents, and restricted cash 375.4 (94.8) (332.8)
Cash, cash equivalents, and restricted cash at beginning of year 772.6 867.4 1,200.2
Cash, cash equivalents, and restricted cash at end of year (Note 5) $ 1,148.0 $ 772.6 $ 867.4