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  <xs:element id="ttwo_SoftwareInternalDevelopmentMember" abstract="true" name="SoftwareInternalDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ttwo_InterestExpenseAndAmortizationOfDebtDiscountPremium" abstract="false" name="InterestExpenseAndAmortizationOfDebtDiscountPremium" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities" abstract="false" name="AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_DeveloperRelationshipMember" abstract="true" name="DeveloperRelationshipMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ttwo_TimeBasedRestrictedUnitsMember" abstract="true" name="TimeBasedRestrictedUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses" abstract="false" name="IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_AccruedLicensesCurrent" abstract="false" name="AccruedLicensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_RelatedPartyTransactionBonusPerFiscalYear" abstract="false" name="RelatedPartyTransactionBonusPerFiscalYear" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="ttwo_SoftwareLicensesMember" abstract="true" name="SoftwareLicensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ttwo_StraussZelnickZMCAdvisorsMember" abstract="true" name="StraussZelnickZMCAdvisorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_SoftwareDevelopmentCostsAndLicensesDisclosureTextBlock" abstract="false" name="SoftwareDevelopmentCostsAndLicensesDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpensesAndOtherLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpensesAndOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_DebtGrossBeforeFairValueAdjustments" abstract="false" name="DebtGrossBeforeFairValueAdjustments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_AnalyticsTechnologyMember" abstract="true" name="AnalyticsTechnologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedCurrentLiabilitiesLeaseObligation" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedCurrentLiabilitiesLeaseObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_DerivativeNotionalAmountToSell" abstract="false" name="DerivativeNotionalAmountToSell" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_BusinessAcquisitionCashPrice" abstract="false" name="BusinessAcquisitionCashPrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="ttwo_AccruedRoyaltiesNoncurrent" abstract="false" name="AccruedRoyaltiesNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_DebtMaturityRemainderOfFiscalYear" abstract="false" name="DebtMaturityRemainderOfFiscalYear" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_SoftwareDevelopmentCostsAndLicensesCurrent" abstract="false" name="SoftwareDevelopmentCostsAndLicensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_KarlSlatoffMember" abstract="true" name="KarlSlatoffMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccountsReceivableNetOfAllowances" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccountsReceivableNetOfAllowances" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ttwo_SettlementRelatedToEmployeeStockPurchasePlan" abstract="false" name="SettlementRelatedToEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_PCAndOtherProductsMember" abstract="true" name="PCAndOtherProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ttwo_AccruedLiabilitesCurrentMember" abstract="true" name="AccruedLiabilitesCurrentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="ttwo_GameEngineTechnologyMember" abstract="true" name="GameEngineTechnologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="ttwo_StockIssuedDuringPeriodSharesRestrictedStockAwardSettlement" abstract="false" name="StockIssuedDuringPeriodSharesRestrictedStockAwardSettlement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="ttwo_PaymentForSettlementOfConvertibleNotes" abstract="false" name="PaymentForSettlementOfConvertibleNotes" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_A0ConvertibleSeniorNotesDue2026Member" abstract="true" name="A0ConvertibleSeniorNotesDue2026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
