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Share-Based Compensation - Share-based Compensation Expense (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Share-based compensation |  |  |
Compensation expense | $ 441,793 | $ 367,588 | $ 303,162
Research and development |  |  |
Share-based compensation |  |  |
Compensation expense | 186,113 | 163,550 | 139,348
Selling, General and Administrative Expense |  |  |
Share-based compensation |  |  |
Compensation expense | $ 255,680 | $ 204,038 | $ 163,814

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