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Collaborative and Licensing Arrangements - Amounts and Classification of Payments (Income/(Expense) (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Research and Development Arrangement, Contract to Perform for Others |  |  |
Total | $ (48,962) | $ (50,871) | $ (50,183)
Accounts payable | 404,997 | 315,111 |
Amgen, Inc | Collaborative Arrangement |  |  |
Research and Development Arrangement, Contract to Perform for Others |  |  |
Collaborative arrangement, inventory purchases | 247,655 | 108,691 | 71,720
Amgen, Inc | Collaborative Arrangement | Related Party |  |  |
Research and Development Arrangement, Contract to Perform for Others |  |  |
Accounts payable | 116,563 | 55,474 |
Cost of sales - product |  |  |
Research and Development Arrangement, Contract to Perform for Others |  |  |
Total | 37,150 | 8,358 | 5,898
Selling, General and Administrative Expense |  |  |
Research and Development Arrangement, Contract to Perform for Others |  |  |
Total | (83,674) | (60,917) | (54,865)
Research and development |  |  |
Research and Development Arrangement, Contract to Perform for Others |  |  |
Total | $ (2,438) | $ 1,688 | $ (1,216)

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