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Collaborative and Licensing Arrangements - Payment Classification (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Research and development collaborative arrangements |  |  |
Total | $ 114,027 | $ 71,165 | $ 74,165
Upfront payments | Research and development expense |  |  |
Research and development collaborative arrangements |  |  |
Total | 60,027 | 46,800 | 68,665
Development milestone payments | Research and development expense |  |  |
Research and development collaborative arrangements |  |  |
Total | 54,000 | 0 | 5,500
Regulatory and commercial milestone payments | Intangible asset |  |  |
Research and development collaborative arrangements |  |  |
Total | $ 0 | $ 24,365 | $ 0

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 808 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (d) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479402/808-10-50-1 + Details
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