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Income Taxes - Significant Components of Deferred Tax Assets (Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | --- | --- | ---
Deferred Tax Assets, Net [Abstract] |  |  |  |
Accruals and reserves | $ 121,549 | $ 106,708 | $ 97,896 |
Net operating losses carryforward | 1,137,890 | 996,588 | 862,214 |
Stock-based compensation | 38,397 | 26,687 | 19,700 |
Research tax credits | 34,561 | 68,117 | 86,000 |
Tax relief credits | 704,928 | 704,928 | 0 |
Intangible asset amortization | 1,081,442 | 699,974 | 813,043 |
Lease liability obligation | 11,882 | 7,893 | 10,348 |
R&D and other capitalized costs | 277,061 | 164,190 | 63,156 |
Total gross deferred tax assets | 3,407,710 | 2,775,085 | 1,952,357 |
Less valuation allowance | (3,403,505) | (2,771,470) | (1,943,775) | $ (1,758,409)
Net deferred tax assets | 4,205 | 3,615 | 8,582 |
Property, plant and equipment, net | (10,795) | (12,374) | (14,480) |
Tax on unremitted earnings | (23,735) | 0 | 0 |
Right of use asset | (11,682) | (7,735) | (10,098) |
Total gross deferred tax liabilities | (46,212) | (20,109) | (24,578) |
Net deferred tax assets/(liabilities) | $ (42,007) | $ (16,494) | $ (15,996) |

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