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Schedule I - Condensed Financial Information of Registrant (Condensed Statements of Operations) (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Operating expenses |  |  |
Research and development expense | $ 1,953,295 | $ 1,778,594 | $ 1,640,508
Selling, general and administrative | 1,831,056 | 1,508,001 | 1,278,603
Total operating expenses | 3,784,351 | 3,286,595 | 2,919,111
Loss from operations | (568,199) | (1,207,736) | (1,789,665)
Interest income, net | 47,836 | 74,009 | 52,480
Other (expense) income, net | (12,638) | 307,891 | (223,852)
Loss before income taxes | (533,001) | (825,836) | (1,961,037)
Income tax expense | 111,785 | 55,872 | 42,778
Net loss | (644,786) | (881,708) | (2,003,815)
Parent Company |  |  |
Operating expenses |  |  |
Research and development expense | 353,903 | 326,560 | 637,152
Selling, general and administrative | 357,103 | 304,543 | 228,801
Total operating expenses | 711,006 | 631,103 | 865,953
Loss from operations | (711,006) | (631,103) | (865,953)
Interest income, net | 3,101 | 48,982 | 39,585
Other (expense) income, net | 63,522 | (297,856) | (1,173,306)
Loss before income taxes | (644,383) | (879,977) | (1,999,674)
Income tax expense | 403 | 1,731 | 4,141
Net loss | $ (644,786) | $ (881,708) | $ (2,003,815)

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