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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities: |  |  |
Net loss | $ (644,786) | $ (881,708) | $ (2,003,815)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization expense | 171,762 | 87,675 | 66,278
Share-based compensation expense | 441,618 | 367,618 | 303,162
Acquired in-process research and development | 60,000 | 46,800 | 68,665
Amortization of research and development cost share liability | (73,226) | (55,294) | (96,402)
Unrealized losses on long-term investments | 24,022 | 16,221 | 21,996
Deferred income tax expense | 25,983 | 689 | 2,059
Gain on BMS termination settlement | 0 | (362,917) | 0
Other items, net | 11,163 | (5,998) | 9,047
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (329,443) | (188,306) | 304,112
Inventories | (91,496) | (140,948) | (56,689)
Other assets | 45,126 | 12,120 | (3,282)
Accounts payable | 121,497 | 21,484 | (4,352)
Accrued expenses and other payables | 111,354 | 180,111 | 45,627
Deferred revenue | 633 | (255,587) | (151,816)
Other liabilities | (14,838) | 587 | (1,209)
Net cash used in operating activities | (140,631) | (1,157,453) | (1,496,619)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (492,663) | (561,896) | (325,434)
Proceeds from sale or maturity of short-term investments | 2,655 | 673,240 | 1,563,618
Purchase of in-process research and development | (31,800) | (15,000) | (143,665)
Purchase of intangible assets | (4,674) | (19,365) | 0
Purchase of long-term investments | (19,006) | (14,900) | (15,911)
Other investing activities | (2,862) | (2,075) | (1,485)
Net cash (used in) provided by investing activities | (548,350) | 60,004 | 1,077,123
Cash flows from financing activities: |  |  |
Proceeds from long-term loan | 9,053 | 22,502 | 37,372
Repayment of long-term loan | (28,031) | (13,690) | 0
Proceeds from short-term loans | 868,270 | 661,530 | 313,774
Repayment of short-term loans | (704,216) | (309,576) | (417,081)
Proceeds from option exercises and employee share purchase plan | 45,373 | 55,712 | 46,964
Other financing activities | 3,000 | 0 | 0
Net cash provided by (used in) financing activities | 193,449 | 416,478 | (18,971)
Effect of foreign exchange rate changes, net | (51,705) | (8,082) | (69,383)
Net decrease in cash, cash equivalents, and restricted cash | (547,237) | (689,053) | (507,850)
Cash, cash equivalents, and restricted cash, beginning of year | 3,185,984 | 3,875,037 | 4,382,887
Cash, cash equivalents, and restricted cash, end of year | 2,638,747 | 3,185,984 | 3,875,037
Supplemental cash flow disclosures: |  |  |
Cash and cash equivalents | 2,627,410 | 3,171,800 | 3,869,564
Short-term restricted cash | 9,312 | 11,473 | 196
Long-term restricted cash | 2,025 | 2,711 | 5,277
Income taxes paid | 69,430 | 56,003 | 29,500
Interest paid | 51,175 | 19,753 | 25,169
Supplemental non-cash activities: |  |  |
Accruals for capital expenditures | 70,314 | 91,804 | 95,346
Purchase of in-process research and development included in accounts payable | $ 60,000 | $ 31,800 | $ 0

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