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Segment and Geographic Information - Schedule of Revenue by Geographic Area (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Net product revenues by geographic area |  |  |
Revenue from contract with customer | $ 3,810,241 | $ 2,458,779 | $ 1,415,921
Product revenue, net |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 3,779,546 | 2,189,852 | 1,254,612
Collaboration revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 30,695 | 268,927 | 161,309
U.S. - total revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 1,957,498 | 1,128,219 | 502,626
U.S. - total revenue | Product revenue, net |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 1,950,530 | 945,551 | 389,710
U.S. - total revenue | Collaboration revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 6,968 | 182,668 | 112,916
China- total revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 1,411,307 | 1,101,951 | 840,032
China- total revenue | Product revenue, net |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 1,390,699 | 1,093,091 | 840,032
China- total revenue | Collaboration revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 20,608 | 8,860 | 0
Europe- total revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 362,626 | 202,014 | 63,257
Europe- total revenue | Product revenue, net |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 359,507 | 122,228 | 14,864
Europe- total revenue | Collaboration revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 3,119 | 79,786 | 48,393
Rest of world- total revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 78,810 | 26,595 | 10,006
Rest of world- total revenue | Product revenue, net |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | 78,810 | 28,982 | 10,006
Rest of world- total revenue | Collaboration revenue |  |  |
Net product revenues by geographic area |  |  |
Revenue from contract with customer | $ 0 | $ (2,387) | $ 0

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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 41 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-41 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 270 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482964/270-10-50-1 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 32 -Subparagraph (ee) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-32 Reference 4: http://fasb.org/us-gaap/role/ref/otherTransitionRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 32 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-32 Reference 5: http://fasb.org/us-gaap/role/ref/otherTransitionRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 32 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-32 Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Topic 924 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 11.L) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479941/924-10-S99-1 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Topic 606 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 5 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479806/606-10-50-5 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 30 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 42 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-42 Reference 10: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 22 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 11: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 40 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-40 Reference 12: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 22 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 13: http://www.xbrl.org/2003/role/disclosureRef -Topic 606 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 4 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479806/606-10-50-4 + Details
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