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Schedule I - Condensed Financial Information of Registrant (Condensed Statements of Operations) (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Operating expenses      
Research and development expense $ 1,953,295 $ 1,778,594 $ 1,640,508
Selling, general and administrative 1,831,056 1,508,001 1,278,603
Total operating expenses 3,784,351 3,286,595 2,919,111
Loss from operations (568,199) (1,207,736) (1,789,665)
Interest income, net 47,836 74,009 52,480
Other (expense) income, net (12,638) 307,891 (223,852)
Loss before income taxes (533,001) (825,836) (1,961,037)
Income tax expense 111,785 55,872 42,778
Net loss (644,786) (881,708) (2,003,815)
Parent Company      
Operating expenses      
Research and development expense 353,903 326,560 637,152
Selling, general and administrative 357,103 304,543 228,801
Total operating expenses 711,006 631,103 865,953
Loss from operations (711,006) (631,103) (865,953)
Interest income, net 3,101 48,982 39,585
Other (expense) income, net 63,522 (297,856) (1,173,306)
Loss before income taxes (644,383) (879,977) (1,999,674)
Income tax expense 403 1,731 4,141
Net loss $ (644,786) $ (881,708) $ (2,003,815)