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Leases
 12 Months Ended
Dec. 31, 2024
Leases [Abstract]  
Leases Leases
The Company has operating leases for office and manufacturing facilities in the U.S., Switzerland, and China. The leases have remaining lease terms of up to six years, some of which include options to extend the leases that have not been included in the calculation of the Company’s lease liabilities and ROU assets. The Company has land use rights, which represent land acquired for the biologics manufacturing facility in Guangzhou, the land acquired for the Company’s research, development and office facility in Changping, Beijing, the land acquired for the Company’s research, development and manufacturing facility in Suzhou, and the land acquired for the Company’s research and development facility in Shanghai. The Company also has certain leases with terms of 12 months or less for certain equipment, office and lab space, which are expensed and not recorded on the balance sheet.
The components of lease expense were as follows:
 Year Ended December 31,
 202420232022
 $$$
Operating lease cost 26,575 25,978 25,938 
Variable lease cost4,580 6,101 6,834 
Short-term lease cost2,897 1,683 1,299 
Total lease cost 34,052 33,762 34,071 
Supplemental balance sheet information related to leases was as follows:
 As of December 31,
 20242023
 $$
Operating lease right-of-use assets60,639 43,490 
Land use rights, net78,670 51,717 
Total operating lease right-of-use assets139,309 95,207 
Current portion of operating lease liabilities17,576 21,950 
Operating lease liabilities, non-current portion44,277 22,251 
Total lease liabilities61,853 44,201 
Maturities of operating lease liabilities are as follows:
Amounts
 $
Year ending December 31, 202519,824 
Year ending December 31, 202613,279 
Year ending December 31, 202712,583 
Year ending December 31, 202811,738 
Year ending December 31, 20297,188 
Thereafter3,922 
Total lease payments68,534 
Less imputed interest(6,681)
Present value of lease liabilities61,853 
Other supplemental information related to leases is summarized below:
 Year ended December 31,
 202420232022
 $$$
Operating cash flows used in operating leases56,005 27,985 28,064 
ROU assets obtained in exchange for new operating lease liabilities47,066 11,854 22,278 
 As of December 31,
 20242023
Weighted-average remaining lease term (years)43
Weighted-average discount rate5.23 %7.22 %