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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Revenues      
Total revenues $ 3,810,241 $ 2,458,779 $ 1,415,921
Gross profit 3,216,152 2,078,859 1,129,446
Operating expenses      
Research and development 1,953,295 1,778,594 1,640,508
Selling, general and administrative 1,831,056 1,508,001 1,278,603
Total operating expenses 3,784,351 3,286,595 2,919,111
Loss from operations (568,199) (1,207,736) (1,789,665)
Interest income, net 47,836 74,009 52,480
Other (expense) income, net (12,638) 307,891 (223,852)
Loss before income taxes (533,001) (825,836) (1,961,037)
Income tax expense 111,785 55,872 42,778
Net loss $ (644,786) $ (881,708) $ (2,003,815)
Net loss per share, basic (in dollars per share) $ (0.47) $ (0.65) $ (1.49)
Net loss per share, diluted (in dollars per share) $ (0.47) $ (0.65) $ (1.49)
Weighted-average shares outstanding—basic (in shares) 1,368,746,793 1,357,034,547 1,340,729,572
Weighted-average shares outstanding— diluted (in shares) 1,368,746,793 1,357,034,547 1,340,729,572
Net loss per American Depositary Share (ADS), basic (in dollars per share) $ (6.12) $ (8.45) $ (19.43)
Net loss per American Depositary Share (ADS), diluted (in dollars per share) $ (6.12) $ (8.45) $ (19.43)
Weighted-average ADSs outstanding, basic (in shares) 105,288,215 104,387,273 103,133,044
Weighted-average ADSs outstanding, diluted (in shares) 105,288,215 104,387,273 103,133,044
Product revenue, net      
Revenues      
Total revenues $ 3,779,546 $ 2,189,852 $ 1,254,612
Cost of sales - product 594,089 379,920 286,475
Collaboration revenue      
Revenues      
Total revenues $ 30,695 $ 268,927 $ 161,309