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Share-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Schedule of Shares Issued Under Employee Share Purchase Plan
The following tables summarizes the shares issued under the ESPP:
Market Price1
Purchase Price2
Issuance DateNumber of Ordinary Shares IssuedADSOrdinaryADSOrdinaryProceeds
August 31, 20241,035,996 $165.20 $12.69 $140.27 $10.78 $11,178 
February 29, 20241,021,397 $165.65 $12.74 $140.80 $10.83 $11,063 
August 31, 2023794,144 $207.55 $15.97 $176.42 $13.57 $10,777 
February 28, 2023930,582 $171.10 $13.16 $145.44 $11.19 $10,414 
August 31, 2022861,315 $171.66 $13.20 $145.91 $11.22 $9,667 
February 28, 2022667,160 $210.52 $16.19 $178.94 $13.76 $9,183 
1 The market price is the lower of the closing price on Nasdaq on the issuance date or the offering date, in accordance with the terms of the ESPP.
2 The purchase price is the price which was discounted from the applicable market price, in accordance with the terms of the ESPP.
Schedule of Share Option Activities
The following table summarizes the Company’s share option activities under the 2011, 2016 and 2018 Plans:
 Number of
Options
Weighted
Average
Exercise
Price
Weighted
Average
Grant
Date Fair
Value
Weighted
Average
Remaining
Contractual
Term
Aggregate
Intrinsic Value
  Years
Outstanding at December 31, 202172,204,888 7.08 
Granted12,516,816 12.34 6.40 
Exercised(5,898,217)4.63 52,258 
Forfeited(2,296,634)16.46 
Outstanding at December 31, 202276,526,853 7.85 
Granted9,817,925 16.37 8.14 
Exercised(6,974,331)4.54 92,051 
Forfeited(1,225,334)17.60 
Outstanding at December 31, 202378,145,113 9.06 
Granted9,180,301 12.53 6.62 
Exercised(6,812,624)3.87 69,946 
Forfeited(2,530,134)15.87 
Outstanding at December 31, 202477,982,656 9.70 4.83429,581 
Exercisable as of December 31, 202460,173,280 8.42 3.7406,868 
Vested and expected to vest at December 31, 202475,311,250 9.55 4.7426,174 
Schedule of the Range of Fair Values and the Assumptions Used to Estimate the Fair Values of the Share Options Granted
The following table presents the range of fair values and the assumptions used to estimate those fair values of the share options granted in the years presented:
 Year Ended December 31, 
 202420232022
Fair value of ordinary share
$5.72 ~ $9.19
$7.26 ~ $10.72
$5.51 ~ $9.04
Risk-free interest rate
3.8% ~ 4.6%
3.4% ~ 4.6%
1.8% ~ 3.9%
Expected exercise multiple
2.8
2.8
2.8
Expected volatility
57% ~ 58%
58% ~ 60%
51% ~ 60%
Expected dividend yield0%0%0%
Contractual life10 years10 years10 years
Schedule of Employee Restricted Shares Activities and Restricted Share Units Activities
The following table summarizes the Company’s restricted share unit activities under the 2016 and 2018 Plans:
 Numbers
of Shares
Weighted-Average
Grant Date Fair Value
  
Outstanding at December 31, 202136,082,982 18.33 
Granted38,707,669 12.46 
Vested(12,533,586)16.37 
Forfeited(6,859,892)16.72 
Outstanding at December 31, 202255,397,173 14.87 
Granted34,573,994 15.57 
Vested(17,862,598)14.71 
Forfeited(5,707,546)15.47 
Outstanding at December 31, 202366,401,023 15.22 
Granted49,693,592 12.53 
Vested(21,251,477)15.53 
Forfeited(9,012,471)14.46 
Outstanding at December 31, 202485,830,667 13.67 
Expected to vest at December 31, 202472,956,067 13.67 
Schedule of Total Compensation Cost Recognized
The following table summarizes total share-based compensation cost recognized for the years ended December 31, 2024, 2023 and 2022:
 Year Ended December 31, 
 202420232022
 $$$
Research and development186,113 163,550 139,348 
Selling, general and administrative255,680 204,038 163,814 
Total441,793 367,588 303,162