<SEC-DOCUMENT>0000093751-26-000283.txt : 20260512
<SEC-HEADER>0000093751-26-000283.hdr.sgml : 20260512
<ACCEPTANCE-DATETIME>20260512115132
ACCESSION NUMBER:		0000093751-26-000283
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20260512
DATE AS OF CHANGE:		20260512

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protagonist Therapeutics, Inc
		CENTRAL INDEX KEY:			0001377121
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				980505495
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-89601
		FILM NUMBER:		26966949

	BUSINESS ADDRESS:	
		STREET 1:		7707 GATEWAY BLVD., SUITE 140
		CITY:			NEWARK
		STATE:			CA
		ZIP:			94560-1160
		BUSINESS PHONE:		(510) 474-0170

	MAIL ADDRESS:	
		STREET 1:		7707 GATEWAY BLVD., SUITE 140
		CITY:			NEWARK
		STATE:			CA
		ZIP:			94560-1160

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Protagonist Therapeutics Inc
		DATE OF NAME CHANGE:	20130605

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Protagonist Inc
		DATE OF NAME CHANGE:	20061002

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			STATE STREET CORP
		CENTRAL INDEX KEY:			0000093751
		STANDARD INDUSTRIAL CLASSIFICATION:	STATE COMMERCIAL BANKS [6022]
		ORGANIZATION NAME:           	02 Finance
		EIN:				042456637
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G

	BUSINESS ADDRESS:	
		STREET 1:		1 CONGRESS STREET
		STREET 2:		SUITE 1
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02114
		BUSINESS PHONE:		617 786-3000

	MAIL ADDRESS:	
		STREET 1:		1 CONGRESS STREET
		STREET 2:		SUITE 1
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	STATE STREET Corp
		DATE OF NAME CHANGE:	20090218

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	STATE STREET CORP
		DATE OF NAME CHANGE:	19970424

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	STATE STREET BOSTON FINANCIAL CORP
		DATE OF NAME CHANGE:	19780525
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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   <schemaVersion>X0202</schemaVersion>
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         <filer>
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               <cik>0000093751</cik>
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         <liveTestFlag>LIVE</liveTestFlag>



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      <coverPageHeader>
         <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
         <eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
         <issuerInfo>
            <issuerCik>0001377121</issuerCik>
            <issuerName>PROTAGONIST THERAPEUTICS INC</issuerName>
            <issuerCusips>
               <issuerCusipNumber>74366E102</issuerCusipNumber>
            </issuerCusips>
            <issuerPrincipalExecutiveOfficeAddress>
               <com:street1>7707 GATEWAY BLVD SUITE 140</com:street1>
               <com:city>NEWARK</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94560</com:zipCode>
            </issuerPrincipalExecutiveOfficeAddress>
         </issuerInfo>
         <designateRulesPursuantThisScheduleFiled>
            <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
         </designateRulesPursuantThisScheduleFiled>
      </coverPageHeader>
      <coverPageHeaderReportingPersonDetails>


         <reportingPersonName>STATE STREET CORPORATION</reportingPersonName>
         <citizenshipOrOrganization>MA</citizenshipOrOrganization>
         <reportingPersonBeneficiallyOwnedNumberOfShares>
            <soleVotingPower>0.00</soleVotingPower>
            <sharedVotingPower>2956605.00</sharedVotingPower>
            <soleDispositivePower>0.00</soleDispositivePower>
            <sharedDispositivePower>3116804.00</sharedDispositivePower>
         </reportingPersonBeneficiallyOwnedNumberOfShares>
         <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3116804.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
         <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
         <classPercent>4.9</classPercent>
         <typeOfReportingPerson>HC</typeOfReportingPerson>
      </coverPageHeaderReportingPersonDetails>
      <items>
         <item1>
            <issuerName>PROTAGONIST THERAPEUTICS INC</issuerName>
            <issuerPrincipalExecutiveOfficeAddress>7707 GATEWAY BLVD SUITE 140, NEWARK, CALIFORNIA, 94560</issuerPrincipalExecutiveOfficeAddress>
         </item1>
         <item2>
            <filingPersonName>STATE STREET CORPORATION;</filingPersonName>
            <principalBusinessOfficeOrResidenceAddress>ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES</principalBusinessOfficeOrResidenceAddress>
            <citizenship>MA</citizenship>
         </item2>
         <item3>
            <notApplicableFlag>N</notApplicableFlag>
            <typeOfPersonFiling>BK</typeOfPersonFiling>
            <typeOfPersonFiling>IA</typeOfPersonFiling>
            <typeOfPersonFiling>HC</typeOfPersonFiling>
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         <item4>
            <amountBeneficiallyOwned>3116804.00</amountBeneficiallyOwned>
            <classPercent>4.9</classPercent>
            <numberOfSharesPersonHas>
               <solePowerOrDirectToVote>0</solePowerOrDirectToVote>
               <sharedPowerOrDirectToVote>2,956,605</sharedPowerOrDirectToVote>
               <solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
               <sharedPowerOrDirectToDispose>3,116,804</sharedPowerOrDirectToDispose>
            </numberOfSharesPersonHas>
         </item4>
         <item5>
            <notApplicableFlag>N</notApplicableFlag>
            <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
         </item5>
         <item6>
            <notApplicableFlag>N</notApplicableFlag>
            <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>NOT APPLICABLE</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
         </item6>
         <item7>
            <notApplicableFlag>N</notApplicableFlag>
            <subsidiaryIdentificationAndClassification>SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET BANK AND TRUST COMPANY (BK);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);STATE STREET GLOBAL ADVISORS, LTD. (IA);</subsidiaryIdentificationAndClassification>
         </item7>
         <item8>
            <notApplicableFlag>N</notApplicableFlag>
            <identificationAndClassificationOfGroupMembers>NOT APPLICABLE</identificationAndClassificationOfGroupMembers>
         </item8>
         <item9>
            <notApplicableFlag>N</notApplicableFlag>
            <groupDissolutionNotice>NOT APPLICABLE</groupDissolutionNotice>
         </item9>
         <item10>
            <notApplicableFlag>N</notApplicableFlag>
            <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
         </item10>
      </items>
      <signatureInformation>
         <reportingPersonName>STATE STREET CORPORATION</reportingPersonName>
         <signatureDetails>
            <signature>ELIZABETH SCHAEFER</signature>
            <title>SENIOR VICE PRESIDENT, CHIEF ACCOUNTING OFFICER</title>
            <date>05/12/2026</date>
         </signatureDetails>
      </signatureInformation>
   </formData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
