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v3.3.1.900

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Operating activities |  |  |
Net loss | $ (118,183) | $ (79,159) | $ (56,073)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,982 | 1,073 | 680
Stock based compensation expense | 15,590 | 11,328 | 8,668
Loss / (gain) on sale of asset, net |  | 9 | (2)
Amortization of debt discount and debt issuance costs | 458 | 390 | 333
Accrual of the end of term charge on the debt | 76 | 110 | 160
Changes in operating assets and liabilities: |  |  |
Prepaid expenses and other assets | (1,484) | (2,972) | (1,832)
Accounts payable | (1,781) | 3,312 | (1,131)
Accrued expenses and other | 2,642 | 1,493 | 2,533
Net cash used in operating activities | (100,700) | (64,416) | (46,664)
Investing activities |  |  |
Purchase of fixed assets | (3,454) | (5,351) | (826)
Proceeds from sale of asset |  | 10 | 2
Maturity of a certificate of deposit |  |  | 2,153
Net cash (used in) / provided by investing activities | (3,454) | (5,341) | 1,329
Financing activities |  |  |
Payments on capital lease obligations |  | (64) | (96)
Proceeds from issuance of debt |  | 5,000 |
Proceeds from issuance of common stock, net | 222,942 | 109,013 | 67,017
Proceeds from exercise of stock options | 5,112 | 1,390 | 1,626
Payment of debt issuance costs | (250) | (250) | (100)
Net cash provided by financing activities | 227,804 | 115,089 | 68,447
Increase in cash and cash equivalents | 123,650 | 45,332 | 23,112
Cash and cash equivalents at beginning of period | 159,226 | 113,894 | 90,782
Cash and cash equivalents at end of period | 282,876 | 159,226 | 113,894
Supplemental disclosures of cash flow information: |  |  |
Cash paid for interest | 2,948 | 1,803 | 1,809
Cash received for taxes, net | $ 3,008 | $ 9,429 | 1,221
Supplemental disclosures of non-cash investing and financing activities: |  |  |
Value of warrant exercised by converting the warrant into shares of common stock ("net issuance method") |  |  | $ 790

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