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Stock-Based Compensation - Restricted Stock and Restricted Stock Units (Details) - USD ($) $ / shares in Units, $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Stock options and RSUs |  |  |
Weighted Average Grant Price |  |  |
Allocated share-based compensation expense | $ 15.6 | $ 11.3 | $ 8.7
Stock-based compensation expense that resulted from the remeasurement of awards | 2.3 | 2.4 | 4.1
Stock options and RSUs | Research and development expenses |  |  |
Weighted Average Grant Price |  |  |
Allocated share-based compensation expense | 4.0 | 4.5 | 2.4
Stock options and RSUs | General and administrative expenses |  |  |
Weighted Average Grant Price |  |  |
Allocated share-based compensation expense | $ 11.6 | $ 6.8 | $ 6.3
Restricted stock units |  |  |
Number of RSUs |  |  |
Outstanding, beginning balance (in shares) | 20,502 | 92,641 | 215,525
Granted (in shares) | 49,776 | 20,502 | 55,317
Released (in shares) | (26,724) | (92,641) | (177,316)
Forfeited (in shares) |  |  | (885)
Outstanding, ending balance (in shares) | 43,554 | 20,502 | 92,641
Expected to Vest (in shares) | 43,554 |  |
Weighted Average Grant Price |  |  |
Outstanding weighted average grant price (in dollars per share) | $ 19.47 | $ 6.27 | $ 6.26
Granted (in dollars per share) | 16.07 | 19.47 | 6.77
Released (in dollars per share) | 18.68 | 6.27 | 6.42
Forfeited (in dollars per share) |  |  | 5.00
Outstanding weighted average grant price (in dollars per share) | 16.07 | $ 19.47 | $ 6.27
Expected to Vest (in dollars per share) | $ 16.07 |  |
Restricted Stock and Restricted Stock Units |  |  |
Stock Based Compensation disclosures |  |  |
Number of common shares each award holder is entitled to receive | 1 |  |

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F + Details
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- Definition The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The weighted average fair value of nonvested awards on equity-based plans excluding option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, revenue or profit achievement stock award plan) for which the employer is contingently obligated to issue equity instruments or transfer assets to an employee who has not yet satisfied service or performance criteria necessary to gain title to proceeds from the sale of the award or underlying shares or units. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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