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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Common Stock | Warrant | Additional Paid-in Capital | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2012 | $ 315 | $ 790 | $ 455,325 | $ (335,548) | $ 120,882
Balance (in shares) at Dec. 31, 2012 | 31,488,000 | 330,000 |  |  |
Comprehensive loss: |  |  |  |  |
Net loss |  |  |  | (56,073) | (56,073)
Exercise of stock options | $ 4 |  | 1,622 |  | $ 1,626
Exercise of stock options (in shares) | 372,000 |  |  |  | 371,743
Net proceeds from issuance of common stock | $ 69 |  | 66,948 |  | $ 67,017
Net proceeds from issuance of common stock (in shares) | 6,900,000 |  |  |  |
Issuance of common stock for vesting of RSUs | $ 1 |  | (1) |  |
Issuance of common stock for vesting of RSUs (in shares) | 154,000 |  |  |  |
Exercise of warrants | $ 2 | $ (790) | 788 |  |
Exercise of warrants (in shares) | 223,000 | (330,000) |  |  |
Reclass of stock compensation expense for liability awards to equity |  |  | 3,371 |  | 3,371
Stock compensation expense |  |  | 6,501 |  | 6,501
Balance at Dec. 31, 2013 | $ 391 |  | 534,554 | (391,621) | 143,324
Balance (in shares) at Dec. 31, 2013 | 39,137,000 |  |  |  |
Comprehensive loss: |  |  |  |  |
Net loss |  |  |  | (79,159) | (79,159)
Exercise of stock options | $ 3 |  | 1,728 |  | $ 1,731
Exercise of stock options (in shares) | 283,000 |  |  |  | 283,057
Net proceeds from issuance of common stock | $ 103 |  | 108,910 |  | $ 109,013
Net proceeds from issuance of common stock (in shares) | 10,306,000 |  |  |  |
Issuance of common stock for vesting of RSUs | $ 1 |  | (1) |  |
Issuance of common stock for vesting of RSUs (in shares) | 80,000 |  |  |  |
Stock compensation expense |  |  | 11,328 |  | 11,328
Balance at Dec. 31, 2014 | $ 498 |  | 656,519 | (470,780) | 186,237
Balance (in shares) at Dec. 31, 2014 | 49,806,000 |  |  |  |
Comprehensive loss: |  |  |  |  |
Net loss |  |  |  | (118,183) | (118,183)
Exercise of stock options | $ 5 |  | 5,107 |  | $ 5,112
Exercise of stock options (in shares) | 481,000 |  |  |  | 481,140
Net proceeds from issuance of common stock | $ 115 |  | 222,827 |  | $ 222,942
Net proceeds from issuance of common stock (in shares) | 11,500,000 |  |  |  |
Issuance of common stock for vesting of RSUs (in shares) | 27,000 |  |  |  |
Stock compensation expense |  |  | 15,590 |  | 15,590
Balance at Dec. 31, 2015 | $ 618 |  | $ 900,043 | $ (588,963) | $ 311,698
Balance (in shares) at Dec. 31, 2015 | 61,814,000 |  |  |  |

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