Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Consolidated Statements of Comprehensive Loss
Other revenue			$ 11,500
Total revenues			11,500
Operating expenses:
Research and development	$ 74,277	$ 56,292	44,279
General and administrative	43,216	31,073	22,236
Total operating expenses	117,493	87,365	66,515
Operating loss	(117,493)	(87,365)	(55,015)
Investment income	261	58	166
Interest expense	(2,889)	(2,415)	(2,412)
Other income/(expense), net	(33)	141	(33)
Loss before income taxes	(120,154)	(89,581)	(57,294)
Benefit from income taxes	(1,971)	(10,422)	(1,221)
Net loss and comprehensive loss	$ (118,183)	$ (79,159)	$ (56,073)
Basic and diluted net loss per share (in dollars per share)	$ (2.02)	$ (1.84)	$ (1.60)
Weighted average basic and diluted common shares outstanding (in shares)	58,633	43,095	34,980

The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

No definition available.