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Stock-Based Compensation - Restricted Stock and Restricted Stock Units (Details) - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Stock options and RSUs
Weighted Average Grant Price
Allocated share-based compensation expense	$ 15.6	$ 11.3	$ 8.7
Stock-based compensation expense that resulted from the remeasurement of awards	2.3	2.4	4.1
Stock options and RSUs | Research and development expenses
Weighted Average Grant Price
Allocated share-based compensation expense	4.0	4.5	2.4
Stock options and RSUs | General and administrative expenses
Weighted Average Grant Price
Allocated share-based compensation expense	$ 11.6	$ 6.8	$ 6.3
Restricted stock units
Number of RSUs
Outstanding, beginning balance (in shares)	20,502	92,641	215,525
Granted (in shares)	49,776	20,502	55,317
Released (in shares)	(26,724)	(92,641)	(177,316)
Forfeited (in shares)			(885)
Outstanding, ending balance (in shares)	43,554	20,502	92,641
Expected to Vest (in shares)	43,554
Weighted Average Grant Price
Outstanding weighted average grant price (in dollars per share)	$ 19.47	$ 6.27	$ 6.26
Granted (in dollars per share)	16.07	19.47	6.77
Released (in dollars per share)	18.68	6.27	6.42
Forfeited (in dollars per share)			5.00
Outstanding weighted average grant price (in dollars per share)	16.07	$ 19.47	$ 6.27
Expected to Vest (in dollars per share)	$ 16.07
Restricted Stock and Restricted Stock Units
Stock Based Compensation disclosures
Number of common shares each award holder is entitled to receive	1

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The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.

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