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Income Taxes (Details)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
NOL carryforwards      
Increase in valuation allowance $ 52,300 $ 15,800  
Unrecognized tax benefits disclosures      
Unrecognized tax benefits, interest and penalties accrued 0 0  
Schedule of components of loss before income taxes      
US (100,278) (89,581) $ (57,294)
Foreign (19,876)    
Loss before income taxes (120,154) (89,581) (57,294)
Current:      
State (2,015) (10,422) (1,221)
Foreign 44    
Total current (1,971) (10,422) (1,221)
Deferred:      
Total $ (1,971) $ (10,422) $ (1,221)
Differences between the U.S. federal statutory tax rate and effective tax rate      
Statutory federal tax rate (as a percent) 34.00% 34.00% 34.00%
Permanent items (as a percent) (4.00%) (3.00%) 0.00%
State income taxes, net of federal benefit (as a percent) 4.00% (7.00%) 7.00%
R&D and other tax credits 12.00% 5.00% 7.00%
Foreign income taxes (as a percent) (1.00%) 0.00% 0.00%
Change in state tax rate (as a percent) 0.00% 0.00% 2.00%
Change in valuation allowance (as a percent) (43.00%) (17.00%) (49.00%)
Other (as a percent) 0.00% 0.00% 1.00%
Effective tax rate (as a percent) 2.00% 12.00% 2.00%
Deferred tax assets:      
Net operating loss carryforwards $ 195,052 $ 160,758  
General business credits 33,360 18,150  
Alternative minimum tax (AMT) credit 418 418  
Other 10,569 7,863  
Gross deferred tax assets 239,399 187,189  
Deferred tax liabilities:      
In-process research and development (23,245) (23,245)  
Deferred tax liabilities (23,245) (23,245)  
Net deferred tax assets 216,154 163,944  
Valuation allowance (216,154) (163,944)  
Federal      
NOL carryforwards      
Net operating loss carryforwards for income tax purposes 538,700    
Net operating loss carryforwards available to offset future taxable income $ 360,400    
Ownership change, as defined in Section 382, which could limit utilization of NOLs (as a percent) 50.00%    
Period of time for measuring ownership changes under Section 382 3 years    
New Jersey      
NOL carryforwards      
State NOLs sold under the State of New Jersey's Technology Business Tax Certificate Transfer Program $ 24,300 110,500 $ 27,000
Cash proceeds from sale of NOLs, net of commissions 2,000 $ 10,400 $ 1,200
Net operating loss carryforwards available to offset future taxable income $ 115,900    
Percentage Company is resident of NJ 100