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License and Collaboration Agreements (Details) - USD ($)
$ in Millions
1 Months Ended 12 Months Ended
Sep. 30, 2015
Jul. 31, 2014
Feb. 28, 2014
Mar. 31, 2013
Dec. 31, 2015
Dec. 31, 2013
Dec. 31, 2011
Dec. 31, 2009
Dec. 31, 2004
Nov. 30, 2015
Apr. 29, 2013
Respironics Agreement                      
Collaboration Agreements                      
Aggregate payment upon the achievement of certain clinical milestones                   $ 7.6  
Eleison License Agreement                      
Collaboration Agreements                      
License revenues             $ 1.0        
Premacure License Agreement                      
Collaboration Agreements                      
License revenues           $ 11.5          
License purchase option price       $ 11.5              
Proceeds from sale of license                     $ 11.5
CFFT                      
Collaboration Agreements                      
Compensation earned under research funding agreements with CFFT               $ 2.2 $ 1.7    
Royalty payable on approval of ARIKAYCE as commercialized drug         $ 13.4            
Royalty payment period         3 years            
Period for meeting sales milestones for additional royalty payments         5 years            
Royalty payable on meeting certain sales milestones         $ 3.9            
Therapure                      
Collaboration Agreements                      
Initial term of contract manufacturing agreement     5 years                
Period of each automatic renewal of contract manufacturing agreement     2 years                
Written notice period required for termination of contract manufacturing agreement     2 years                
Therapure | Minimum                      
Collaboration Agreements                      
Advance notice period for termination of contract manufacturing agreement by the entity     180 days                
PARI Agreement                      
Collaboration Agreements                      
Initial term of contract manufacturing agreement   15 years                  
Additional term of contract manufacturing agreement   5 years                  
PARI Agreement | Minimum                      
Collaboration Agreements                      
Written notice period required for termination of contract manufacturing agreement   1 year                  
Fill/Finish Agreement                      
Collaboration Agreements                      
Minimum obligation $ 2.7                    
Extension period 2 years                    
Period prior to expiration for extension 1 year