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Quarterly Financial Data (Unaudited) (Tables) | 12 Months Ended
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Dec. 31, 2018
Quarterly Financial Information Disclosure [Abstract] |
Summary of Quarterly Financial Data (Unaudited) | The following table summarizes unaudited quarterly financial data for the years ended December 31, 2018 and 2017 (in thousands, except per share data).
| 2018
| First Quarter |  | Second Quarter |  | Third Quarter |  | Fourth Quarter |  | Total
Revenues | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | 9,835 |  |  | $ | 9,835 |
Cost of product revenues* | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | 2,423 |  |  | $ | 2,423 |
Operating loss | $ | (62,751 | ) |  | $ | (72,882 | ) |  | $ | (83,983 | ) |  | $ | (87,722 | ) |  | $ | (307,338 | )
Net loss | $ | (68,524 | ) |  | $ | (76,437 | ) |  | $ | (87,743 | ) |  | $ | (91,573 | ) |  | $ | (324,277 | )
Basic and diluted net loss per share | $ | (0.89 | ) |  | $ | (1.00 | ) |  | $ | (1.14 | ) |  | $ | (1.19 | ) |  | $ | (4.22 | )
| 2017
| First Quarter |  | Second Quarter |  | Third Quarter |  | Fourth Quarter** |  | Total**
Revenues | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |
Cost of product revenues* | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |
Operating loss | $ | (35,969 | ) |  | $ | (43,515 | ) |  | $ | (44,083 | ) |  | $ | (65,353 | ) |  | $ | (188,920 | )
Net loss | $ | (37,414 | ) |  | $ | (44,672 | ) |  | $ | (45,179 | ) |  | $ | (65,384 | ) |  | $ | (192,649 | )
Basic and diluted net loss per share | $ | (0.60 | ) |  | $ | (0.72 | ) |  | $ | (0.69 | ) |  | $ | (0.85 | ) |  | $ | (2.89 | )
________________ * Excludes amortization of intangible assets. ** Includes a one-time payment in October 2017 related to the buy-down of royalties payable to PARI on the global net sales of ARIKAYCE.

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- Definition Tabular disclosure of quarterly financial data. Includes, but is not limited to, financial information for fiscal quarters, cumulative effect of a change in accounting principle and earnings per share data. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=109225645&loc=d3e1280-108306 + Details
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