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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Accounting Policies [Abstract] |
Schedule of Carrying Value and Fair Value of Assets and Liabilities | The following table shows assets and liabilities that are measured at fair value on a recurring basis and their carrying value (in millions):
| As of December 31, 2018
|  |  | Fair Value
| Carrying Value |  | Level 1 |  | Level 2 |  | Level 3
Cash and cash equivalents | $ | 495.1 |  |  | $ | 495.1 |  |  | $ | — |  |  | $ | — |
| As of December 31, 2017
|  |  | Fair Value
| Carrying Value |  | Level 1 |  | Level 2 |  | Level 3
Cash and cash equivalents | $ | 381.2 |  |  | $ | 381.2 |  |  | $ | — |  |  | $ | — |
Schedules of Concentration of Risk, by Risk Factor | The following table presents the percentage of gross product revenue represented by the Company's three largest customers as of the year ended December 31, 2018.
| Percentage of Total Gross Product Revenue
Customer A | 37%
Customer B | 27%
Customer C | 19%
Contract with Customer, Asset, Allowance for Credit Loss | The following table provides a summary roll-forward of our sales allowances and related accruals for the year ended December 31, 2018 (in thousands), which have been deducted in arriving at net product revenue:
| Customer fees, discounts and other |  | Rebates, chargebacks and co-pay assistance |  | Total
Balance as of January 1, 2018 | $ | — |  |  | $ | — |  |  | $ | — |
Allowances for current period sales | 335 |  |  | 849 |  |  | 1,184 |
Payments and credits | (101 | ) |  | (161 | ) |  | (262 | )
Balance as of December 31, 2018 | $ | 234 |  |  | $ | 688 |  |  | $ | 922 |
Reconciliation of the Weighted Average Number of Shares Used to Compute Basic and Diluted Net Loss per Share | The following table sets forth the reconciliation of the weighted average number of shares used to compute basic and diluted net loss per share for the years ended December 31, 2018, 2017 and 2016.
| Years Ended December 31,
2018 |  | 2017 |  | 2016
(in thousands, except per share amounts)
Numerator: |  |  |  |  |  |  |  |
Net loss | $ | (324,277 | ) |  | $ | (192,649 | ) |  | $ | (176,273 | )
Denominator: |  |  |  |  |  |  |  |
Weighted average common shares used in calculation of basic net loss per share: | 76,889 |  |  | 66,576 |  |  | 61,892 |
Effect of dilutive securities: |  |  |  |  |  |  |  |
Common stock options | — |  |  | — |  |  | — |
Restricted stock and restricted stock units | — |  |  | — |  |  | — |
Weighted average common shares outstanding used in calculation of diluted net loss per share | 76,889 |  |  | 66,576 |  |  | 61,892 |
Net loss per share: |  |  |  |  |  |  |  |
Basic and diluted | $ | (4.22 | ) |  | $ | (2.89 | ) |  | $ | (2.85 | )
Potentially Dilutive Securities Excluded from Computations of Diluted Weighted Average Common Shares Outstanding | The following potentially dilutive securities have been excluded from the computations of diluted weighted average common shares outstanding as of December 31, 2018, 2017 and 2016 as their effect would have been anti-dilutive (in thousands).
| 2018 |  | 2017 |  | 2016
Stock options to purchase common stock | 9,382 |  |  | 8,609 |  |  | 7,117 |
Unvested restricted stock units | 228 |  |  | 47 |  |  | 89 |
Convertible debt securities | 11,492 |  |  | — |  |  | — |

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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 + Details
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- Definition Tabular disclosure of assets and liabilities, including [financial] instruments measured at fair value that are classified in stockholders' equity, if any, that are measured at fair value on a recurring basis. The disclosures contemplated herein include the fair value measurements at the reporting date by the level within the fair value hierarchy in which the fair value measurements in their entirety fall, segregating fair value measurements using quoted prices in active markets for identical assets (Level 1), significant other observable inputs (Level 2), and significant unobservable inputs (Level 3). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19190-110258 + Details
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