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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2018
Income Tax Disclosure [Abstract] |
Schedule of Loss Before Income Taxes in the US and Globally | The Company's loss before income taxes in the US and globally was as follows (in thousands):
| Years Ended December 31,
2018 |  | 2017 |  | 2016
US | $ | (286,211 | ) |  | $ | (136,682 | ) |  | $ | (140,354 | )
Foreign | (37,865 | ) |  | (56,239 | ) |  | (35,821 | )
Total | $ | (324,076 | ) |  | $ | (192,921 | ) |  | $ | (176,175 | )
Schedule of Components Income Tax (Benefit) Provision | The Company's income tax (benefit) provision consisted of the following (in thousands):
| Years Ended December 31,
| 2018 |  | 2017 |  | 2016
Current: |  |  |  |  |  |  |  |
Federal | $ | — |  |  | $ | — |  |  | $ | — |
State | 4 |  |  | 3 |  |  | 3 |
Foreign | 197 |  |  | 142 |  |  | 95 |
| 201 |  |  | 145 |  |  | 98 |
Deferred: |  |  |  |  |  |  |  |
Federal | — |  |  | (417 | ) |  | — |
State | — |  |  | — |  |  | — |
Foreign | — |  |  | — |  |  | — |
| — |  |  | (417 | ) |  | — |
Total | $ | 201 |  |  | $ | (272 | ) |  | $ | 98 |
Reconciliation Between Federal Statutory Tax Rate and Effective Tax Rate | The reconciliation between the federal statutory tax rates and the Company's effective tax rate is as follows:
| Years Ended December 31,
| 2018 |  | 2017 |  | 2016
Statutory federal tax rate | 21 | % |  | 34 | % |  | 34 | %
Permanent items | — | % |  | (3 | )% |  | (3 | )%
State income taxes, net of federal benefit | 5 | % |  | 4 | % |  | 4 | %
R&D and other tax credits | 2 | % |  | 8 | % |  | 8 | %
Foreign income taxes | (1 | )% |  | (6 | )% |  | (4 | )%
Impact of Tax Act | — | % |  | (49 | )% |  | — | %
Change in valuation allowance | (27 | )% |  | 12 | % |  | (39 | )%
Other | — | % |  | — | % |  | — | %
Effective tax rate | — | % |  | — | % |  | — | %
Schedule of Components of Deferred Tax Assets and Liabilities | The components of the deferred tax assets and liabilities consist of the following:
| As of December 31,
| 2018 |  | 2017
Deferred tax assets: |  |  |  |  |
Net operating loss carryforwards | $ | 231,918 |  |  | $ | 186,342 |
General business credits | 109,502 |  |  | 66,371 |
Product license | 6,902 |  |  | 7,730 |
Inventory | 7,651 |  |  | — |
Other | 24,855 |  |  | 17,217 |
Gross deferred tax assets | $ | 380,828 |  |  | $ | 277,660 |
Deferred tax liabilities: |  |  |  |  |
Intangibles | $ | (15,424 | ) |  | $ | (16,360 | )
Convertible debt | (32,799 | ) |  | — |
Deferred tax liabilities | $ | (48,223 | ) |  | $ | (16,360 | )
Net deferred tax assets | $ | 332,605 |  |  | $ | 261,300 |
Valuation allowance | (332,605 | ) |  | (261,300 | )
Net deferred tax assets | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits | The following table summarizes the gross amounts of unrecognized tax benefits (in thousands):
| Net Deferred Tax Assets
Balance as of January 1, | $ | — |  |  | $ | — |
Additions related to prior period tax positions | 3,345 |  |  | — |
Additions related to current period tax positions | 742 |  |  | — |
Balance as of December 31, | $ | 4,087 |  |  | $ | — |

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319 + Details
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- Definition Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15A -URI http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32718-109319 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32840-109319 + Details
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