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v3.10.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Operating activities |  |  |
Net loss | $ (324,277) | $ (192,649) | $ (176,273)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 3,577 | 2,901 | 2,438
Amortization of intangible assets | 1,249 | 0 | 0
Stock-based compensation expense | 26,240 | 18,073 | 18,039
Amortization of debt issuance costs | 1,350 | 118 | 281
Loss on extinguishment of debt | 2,209 | 0 | 0
Accretion of debt discount | 15,889 | 0 |
Accretion of back-end fee on debt | 50 | 658 | 171
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (5,515) | 0 | 0
Inventory | (7,032) | 0 | 0
Prepaid expenses and other assets | (5,514) | (2,783) | 191
Accounts payable | 3,870 | 3,604 | 2,767
Accrued expenses and other | 19,916 | 5,201 | 3,043
Accrued compensation | 10,011 | 5,260 | 2,635
Net cash used in operating activities | (257,977) | (159,617) | (146,708)
Investing activities |  |  |
Purchase of fixed assets | (13,090) | (3,001) | (4,200)
PARI milestone upon FDA approval | (1,724) | 0 | 0
Net cash used in investing activities | (14,814) | (3,001) | (4,200)
Financing activities |  |  |
Proceeds from issuance of 1.75% convertible senior notes due 2025 | 450,000 | 0 | 0
Payment on extinguishment of debt | (2,835) | 0 | 0
Payment of debt | (55,000) | 0 | 0
Proceeds from issuance of debt | 0 | 0 | 30,000
Proceeds from issuance of common stock, net | 0 | 377,656 | 0
Proceeds from exercise of stock options and ESPP | 8,815 | 3,433 | 1,084
Payment of debt issuance costs | (14,237) | 0 | (411)
Net cash provided by financing activities | 386,743 | 381,089 | 30,673
Effect of exchange rates on cash and cash equivalents | (45) | 103 | (50)
Net increase (decrease) in cash and cash equivalents | 113,907 | 218,574 | (120,285)
Cash and cash equivalents at beginning of period | 381,165 | 162,591 | 282,876
Cash and cash equivalents at end of period | 495,072 | 381,165 | 162,591
Supplemental disclosures of cash flow information: |  |  |
Cash paid for interest | 6,289 | 5,165 | 3,608
Cash paid for taxes, net | $ 154 | $ 166 | $ 85
1.75% Convertible Senior Note Due 2025 | Convertible Notes Payable |  |  |
Supplemental disclosures of cash flow information: |  |  |
Proceeds from issuance of 1.75% convertible senior notes due 2025 | 1.75% |  |

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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109197908&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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