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Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 231,918 | $ 186,342
General business credits | 109,502 | 66,371
Product license | 6,902 | 7,730
Inventory | 7,651 | 0
Other | 24,855 | 17,217
Gross deferred tax assets | 380,828 | 277,660
Deferred tax liabilities: |  |
Intangibles | (15,424) | (16,360)
Convertible debt | (32,799) | 0
Deferred tax liabilities | (48,223) | (16,360)
Net deferred tax assets | 332,605 | 261,300
Valuation allowance | (332,605) | (261,300)
Net deferred tax assets | $ 0 | $ 0

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