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Fixed Assets, net (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 36,809 | $ 23,077 |
Less accumulated depreciation | (14,173) | (10,645) |
Fixed assets, net | 22,636 | 12,432 |
Depreciation expense | 3,600 | 2,900 | $ 2,400
Depreciation increase (decrease) | 10,200 |  |
Lab equipment |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 7,935 | 7,055 |
Estimated Useful Life (years) | 7 years |  |
Furniture and fixtures |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 2,320 | 1,937 |
Estimated Useful Life (years) | 7 years |  |
Computer hardware and software |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 3,796 | 2,325 |
Computer hardware and software | Minimum |  |  |
Property, Plant and Equipment |  |  |
Estimated Useful Life (years) | 3 years |  |
Computer hardware and software | Maximum |  |  |
Property, Plant and Equipment |  |  |
Estimated Useful Life (years) | 5 years |  |
Office equipment |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 65 | 65 |
Estimated Useful Life (years) | 7 years |  |
Manufacturing equipment |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 1,166 | 1,436 |
Estimated Useful Life (years) | 7 years |  |
Leasehold improvements |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | $ 7,202 | 6,939 |
Construction in progress (CIP) |  |  |
Property, Plant and Equipment |  |  |
Fixed assets, gross | 14,325 | $ 3,320 |
Depreciation increase (decrease) | $ 11,000 |  |

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