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Fixed Assets, net
 12 Months Ended
Dec. 31, 2018
Property, Plant and Equipment [Abstract]  
Fixed Assets, net Fixed Assets, net
Fixed assets are stated at cost and depreciated using the straight-line method, based on useful lives as follows:
 
Estimated
Useful Life (years)
 
As of December 31,
Asset Description
 
2018
 
2017
 
 
 
(in thousands)
Lab equipment
7
 
$
7,935

 
$
7,055

Furniture and fixtures
7
 
2,320

 
1,937

Computer hardware and software
3 - 5
 
3,796

 
2,325

Office equipment
7
 
65

 
65

Manufacturing equipment
7
 
1,166

 
1,436

Leasehold improvements
lease term
 
7,202

 
6,939

Construction in progress (CIP)
—

14,325


3,320

 
 
 
36,809

 
23,077

Less accumulated depreciation
 
 
(14,173
)
 
(10,645
)
Fixed assets, net
 
 
$
22,636

 
$
12,432


Depreciation expense was $3.6 million, $2.9 million and $2.4 million for the years ended December 31, 2018, 2017 and 2016, respectively.
Fixed assets, net of depreciation, increased to $22.6 million during the year ended December 31, 2018 from $12.4 million in 2017. The $10.2 million increase was primarily due to $11.0 million in construction in progress related to the long-term capacity build-out at the Patheon manufacturing facility.