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Quarterly Financial Data (Unaudited)
 12 Months Ended
Dec. 31, 2018
Quarterly Financial Information Disclosure [Abstract]  
Quarterly Financial Data (Unaudited) Quarterly Financial Data (Unaudited)
The following table summarizes unaudited quarterly financial data for the years ended December 31, 2018 and 2017 (in thousands, except per share data).
 
2018
 
First
Quarter
 
Second
Quarter
 
Third
Quarter
 
Fourth
Quarter
 
Total
Revenues
$
—

 
$
—

 
$
—

 
$
9,835

 
$
9,835

Cost of product revenues*
$
—

 
$
—

 
$
—

 
$
2,423

 
$
2,423

Operating loss
$
(62,751
)
 
$
(72,882
)
 
$
(83,983
)
 
$
(87,722
)
 
$
(307,338
)
Net loss
$
(68,524
)
 
$
(76,437
)
 
$
(87,743
)
 
$
(91,573
)
 
$
(324,277
)
Basic and diluted net loss per share
$
(0.89
)
 
$
(1.00
)
 
$
(1.14
)
 
$
(1.19
)
 
$
(4.22
)
 
 
2017
 
First
Quarter
 
Second
Quarter
 
Third
Quarter
 
Fourth
Quarter**
 
Total**
Revenues
$
—

 
$
—

 
$
—

 
$
—

 
$
—

Cost of product revenues*
$
—

 
$
—

 
$
—

 
$
—

 
$
—

Operating loss
$
(35,969
)
 
$
(43,515
)
 
$
(44,083
)
 
$
(65,353
)
 
$
(188,920
)
Net loss
$
(37,414
)
 
$
(44,672
)
 
$
(45,179
)
 
$
(65,384
)
 
$
(192,649
)
Basic and diluted net loss per share
$
(0.60
)
 
$
(0.72
)
 
$
(0.69
)
 
$
(0.85
)
 
$
(2.89
)
________________
* Excludes amortization of intangible assets.
** Includes a one-time payment in October 2017 related to the buy-down of royalties payable to PARI on the global net sales of ARIKAYCE.
Basic and diluted net loss per share amounts included in the above table were computed independently for each of the quarters presented. Accordingly, the sum of the quarterly basic and diluted net loss per share amounts may not agree to the total for the year.