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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Accounting Policies [Abstract]

Schedule of Carrying Value and Fair Value of Assets and Liabilities

The following table shows assets and liabilities that are measured at fair value on a recurring basis and their carrying value (in millions):

	As of December 31, 2018
					Fair Value
	Carrying Value				Level 1				Level 2				Level 3
Cash and cash equivalents	$	495.1			$	495.1			$	—			$	—
	As of December 31, 2017
					Fair Value
	Carrying Value				Level 1				Level 2				Level 3
Cash and cash equivalents	$	381.2			$	381.2			$	—			$	—

     

Schedules of Concentration of Risk, by Risk Factor

The following table presents the percentage of gross product revenue represented by the Company's three largest customers as of the year ended December 31, 2018.

	Percentage of Total Gross Product Revenue
Customer A	37%
Customer B	27%
Customer C	19%

Contract with Customer, Asset, Allowance for Credit Loss

The following table provides a summary roll-forward of our sales allowances and related accruals for the year ended December 31, 2018 (in thousands), which have been deducted in arriving at net product revenue:

	Customer fees, discounts and other				Rebates, chargebacks and co-pay assistance				Total
Balance as of January 1, 2018	$	—			$	—			$	—
Allowances for current period sales	335				849				1,184
Payments and credits	(101		)		(161		)		(262		)
Balance as of December 31, 2018	$	234			$	688			$	922

Reconciliation of the Weighted Average Number of Shares Used to Compute Basic and Diluted Net Loss per Share

The following table sets forth the reconciliation of the weighted average number of shares used to compute basic and diluted net loss per share for the years ended December 31, 2018, 2017 and 2016.

	Years Ended December 31,
	2018				2017				2016
	(in thousands, except per share amounts)
Numerator:
Net loss	$	(324,277	)		$	(192,649	)		$	(176,273	)
Denominator:
Weighted average common shares used in calculation of basic net loss per share:	76,889				66,576				61,892
Effect of dilutive securities:
Common stock options	—				—				—
Restricted stock and restricted stock units	—				—				—
Weighted average common shares outstanding used in calculation of diluted net loss per share	76,889				66,576				61,892
Net loss per share:
Basic and diluted	$	(4.22	)		$	(2.89	)		$	(2.85	)

Potentially Dilutive Securities Excluded from Computations of Diluted Weighted Average Common Shares Outstanding

The following potentially dilutive securities have been excluded from the computations of diluted weighted average common shares outstanding as of December 31, 2018, 2017 and 2016 as their effect would have been anti-dilutive (in thousands).

	2018			2017			2016
Stock options to purchase common stock	9,382			8,609			7,117
Unvested restricted stock units	228			47			89
Convertible debt securities	11,492			—			—

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