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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Schedule of Loss Before Income Taxes in the US and Globally

The Company's loss before income taxes in the US and globally was as follows (in thousands):

	Years Ended December 31,
	2018				2017				2016
US	$	(286,211	)		$	(136,682	)		$	(140,354	)
Foreign	(37,865		)		(56,239		)		(35,821		)
Total	$	(324,076	)		$	(192,921	)		$	(176,175	)

Schedule of Components Income Tax (Benefit) Provision

The Company's income tax (benefit) provision consisted of the following (in thousands):

	Years Ended December 31,
	2018				2017				2016
Current:
Federal	$	—			$	—			$	—
State	4				3				3
Foreign	197				142				95
	201				145				98
Deferred:
Federal	—				(417		)		—
State	—				—				—
Foreign	—				—				—
	—				(417		)		—
Total	$	201			$	(272	)		$	98

Reconciliation Between Federal Statutory Tax Rate and Effective Tax Rate

The reconciliation between the federal statutory tax rates and the Company's effective tax rate is as follows:

	Years Ended December 31,
	2018			2017			2016
Statutory federal tax rate	21	%		34	%		34	%
Permanent items	—	%		(3	)%		(3	)%
State income taxes, net of federal benefit	5	%		4	%		4	%
R&D and other tax credits	2	%		8	%		8	%
Foreign income taxes	(1	)%		(6	)%		(4	)%
Impact of Tax Act	—	%		(49	)%		—	%
Change in valuation allowance	(27	)%		12	%		(39	)%
Other	—	%		—	%		—	%
Effective tax rate	—	%		—	%		—	%

Schedule of Components of Deferred Tax Assets and Liabilities

The components of the deferred tax assets and liabilities consist of the following:

	As of December 31,
	2018				2017
Deferred tax assets:
Net operating loss carryforwards	$	231,918			$	186,342
General business credits	109,502				66,371
Product license	6,902				7,730
Inventory	7,651				—
Other	24,855				17,217
Gross deferred tax assets	$	380,828			$	277,660
Deferred tax liabilities:
Intangibles	$	(15,424	)		$	(16,360	)
Convertible debt	(32,799		)		—
Deferred tax liabilities	$	(48,223	)		$	(16,360	)
Net deferred tax assets	$	332,605			$	261,300
Valuation allowance	(332,605		)		(261,300		)
Net deferred tax assets	$	—			$	—

Schedule of Unrecognized Tax Benefits

The following table summarizes the gross amounts of unrecognized tax benefits (in thousands):

	Net Deferred Tax Assets
Balance as of January 1,	$	—			$	—
Additions related to prior period tax positions	3,345				—
Additions related to current period tax positions	742				—
Balance as of December 31,	$	4,087			$	—

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