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Summary of Significant Accounting Policies - Net Loss Per Common Share (Details) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Numerator:                      
Net loss $ (91,573) $ (87,743) $ (76,437) $ (68,524) $ (65,384) $ (45,179) $ (44,672) $ (37,414) $ (324,277) $ (192,649) $ (176,273)
Denominator:                      
Weighted average common shares used in calculation of basic net loss per share (in shares)                 76,889 66,576 61,892
Effect of dilutive securities:                      
Weighted average common shares outstanding used in calculation of diluted net loss per share (in shares)                 76,889 66,576 61,892
Net loss per share:                      
Basic and diluted (in dollars per share) $ (1.19) $ (1.14) $ (1.00) $ (0.89) $ (0.85) $ (0.69) $ (0.72) $ (0.60) $ (4.22) $ (2.89) $ (2.85)
Common stock options                      
Effect of dilutive securities:                      
Dilutive securities (in shares)                 0 0 0
Restricted stock and restricted stock units                      
Effect of dilutive securities:                      
Dilutive securities (in shares)                 0 0 0