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Consolidated Statements of Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
Total revenues $ 9,835 $ 0 $ 0
Costs and expenses:      
Cost of product revenues (excluding amortization of intangible assets) 2,423 0 0
Research and development 145,283 109,749 122,721
Selling, general and administrative 168,218 79,171 50,679
Amortization of intangible assets 1,249 0 0
Total costs and expenses 317,173 188,920 173,400
Operating loss (307,338) (188,920) (173,400)
Investment income 10,341 1,624 604
Interest expense (25,472) (5,925) (3,498)
Loss on extinguishment of debt (2,209) 0 0
Other income, net 602 300 119
Loss before income taxes (324,076) (192,921) (176,175)
Provision (benefit) for income taxes 201 (272) 98
Net loss $ (324,277) $ (192,649) $ (176,273)
Basic and diluted net loss (in dollars per share) $ (4.22) $ (2.89) $ (2.85)
Weighted average basic and diluted common shares outstanding (in shares) 76,889 66,576 61,892
Net loss $ (324,277) $ (192,649) $ (176,273)
Other comprehensive income (loss):      
Foreign currency translation (losses) gains (6) 62 (65)
Total comprehensive loss $ (324,283) $ (192,587) $ (176,338)