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Intangibles, net (Details) - USD ($)
$ in Thousands
 12 Months Ended
Sep. 28, 2018
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Jan. 01, 2018
Jan. 01, 2017
Goodwill and Intangible Assets Disclosure [Abstract]            
New drug milestone payment $ 1,700 $ 1,724 $ 0 $ 0    
Intangibles, net   $ 58,675 58,200      
Intangible assets estimated useful life   12 years        
Amortization of intangible assets, 2019   $ 5,000        
Amortization of intangible assets, 2020   5,000        
Amortization of intangible assets, 2021   5,000        
Amortization of intangible assets, 2022   5,000        
Amortization of intangible assets, 2023   5,000        
Finite-lived Intangible Assets [Roll Forward]            
Intangibles, gross         $ 58,200 $ 58,200
Additions   1,724 0      
Amortization   (1,249) 0      
Intangibles, net   58,675 58,200      
In Process Research and Development            
Goodwill and Intangible Assets Disclosure [Abstract]            
Intangibles, net   56,988 58,200      
Finite-lived Intangible Assets [Roll Forward]            
Intangibles, gross         58,200 $ 58,200
Additions   0 0      
Amortization   (1,212) 0      
Intangibles, net   56,988 $ 58,200      
Licensing Agreements            
Goodwill and Intangible Assets Disclosure [Abstract]            
Intangibles, net   1,687        
Finite-lived Intangible Assets [Roll Forward]            
Intangibles, gross         $ 0  
Additions   1,724        
Amortization   (37)        
Intangibles, net   $ 1,687