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Income Taxes - Reconciliation Between Federal Statutory Tax Rate and Effective Tax Rate (Details)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income Tax Disclosure [Abstract]
Statutory federal tax rate	21.00%	34.00%	34.00%
Permanent items	0.00%	(3.00%)	(3.00%)
State income taxes, net of federal benefit	5.00%	4.00%	4.00%
R&D and other tax credits	2.00%	8.00%	8.00%
Foreign income taxes	(1.00%)	(6.00%)	(4.00%)
Impact of Tax Act	0.00%	(49.00%)	0.00%
Change in valuation allowance	(27.00%)	12.00%	(39.00%)
Other	0.00%	0.00%	0.00%
Effective tax rate	0.00%	0.00%	0.00%

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The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate attributable to permanent items.

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Effective Income Tax Rate Reconciliation, Tax Cuts And Jobs Act Of 2017, Percent

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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