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Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Deferred tax assets:
Net operating loss carryforwards	$ 231,918	$ 186,342
General business credits	109,502	66,371
Product license	6,902	7,730
Inventory	7,651	0
Other	24,855	17,217
Gross deferred tax assets	380,828	277,660
Deferred tax liabilities:
Intangibles	(15,424)	(16,360)
Convertible debt	(32,799)	0
Deferred tax liabilities	(48,223)	(16,360)
Net deferred tax assets	332,605	261,300
Valuation allowance	(332,605)	(261,300)
Net deferred tax assets	$ 0	$ 0

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