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Quarterly Financial Data (Unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]
Total revenues	$ 9,835	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 9,835	$ 0	$ 0
Cost of product revenues	2,423	0	0	0	0	0	0	0	2,423	0	0
Operating loss	(87,722)	(83,983)	(72,882)	(62,751)	(65,353)	(44,083)	(43,515)	(35,969)	(307,338)	(188,920)	(173,400)
Net loss	$ (91,573)	$ (87,743)	$ (76,437)	$ (68,524)	$ (65,384)	$ (45,179)	$ (44,672)	$ (37,414)	$ (324,277)	$ (192,649)	$ (176,273)
Basic and diluted net loss (in dollars per share)	$ (1.19)	$ (1.14)	$ (1.00)	$ (0.89)	$ (0.85)	$ (0.69)	$ (0.72)	$ (0.60)	$ (4.22)	$ (2.89)	$ (2.85)

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The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

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