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Consolidated Statements of Shareholders' Equity (unaudited) - USD ($) shares in Thousands, $ in Thousands | Total | Stock Options and ESPP Shares | Common Stock | Common Stock Stock Options and ESPP Shares | Additional Paid-in Capital | Additional Paid-in Capital Stock Options and ESPP Shares | Accumulated Deficit | Accumulated Other Comprehensive Loss
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2018 | $ 208,266 |  | $ 773 |  | $ 1,489,664 |  | $ (1,282,162) | $ (9)
Balance (in shares) at Dec. 31, 2018 |  |  | 77,308 |  |  |  |  |
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] |  |  |  |  |  |  |  |
Net loss | (140,667) |  |  |  |  |  | (140,667) |
Other comprehensive income (loss) | 2 |  |  |  |  |  |  | 2
Exercise of stock options and ESPP shares (in shares) |  |  |  | 1,163 |  |  |  |
Exercise of stock options and ESPP shares |  | $ 13,504 |  | $ 11 |  | $ 13,493 |  |
Net proceeds from issuance of common stock | 261,178 |  | $ 107 |  | 261,071 |  |  |
Net proceeds from issuance of common stock (in shares) |  |  | 10,658 |  |  |  |  |
Issuance of common stock for vesting of RSUs | 1 |  | $ 1 |  |  |  |  |
Issuance of common stock for vesting of RSUs (in shares) |  |  | 78 |  |  |  |  |
Stock compensation expense | 14,289 |  |  |  | 14,289 |  |  |
Balance at Jun. 30, 2019 | 356,573 |  | $ 892 |  | 1,778,517 |  | (1,422,829) | (7)
Balance (in shares) at Jun. 30, 2019 |  |  | 89,207 |  |  |  |  |
Balance at Mar. 31, 2019 | 144,137 |  | $ 776 |  | 1,499,646 |  | (1,356,315) | 30
Balance (in shares) at Mar. 31, 2019 |  |  | 77,596 |  |  |  |  |
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] |  |  |  |  |  |  |  |
Net loss | (66,514) |  |  |  |  |  | (66,514) |
Other comprehensive income (loss) | (37) |  |  |  |  |  |  | (37)
Exercise of stock options and ESPP shares (in shares) |  |  |  | 910 |  |  |  |
Exercise of stock options and ESPP shares |  | 10,455 |  | $ 8 |  | 10,447 |  |
Net proceeds from issuance of common stock | 261,178 |  | $ 107 |  | 261,071 |  |  |
Net proceeds from issuance of common stock (in shares) |  |  | 10,658 |  |  |  |  |
Issuance of common stock for vesting of RSUs | 1 |  | $ 1 |  |  |  |  |
Issuance of common stock for vesting of RSUs (in shares) |  |  | 43 |  |  |  |  |
Stock compensation expense | 7,353 |  |  |  | 7,353 |  |  |
Balance at Jun. 30, 2019 | 356,573 |  | $ 892 |  | 1,778,517 |  | (1,422,829) | (7)
Balance (in shares) at Jun. 30, 2019 |  |  | 89,207 |  |  |  |  |
Balance at Dec. 31, 2019 | 261,674 |  | $ 897 |  | 1,797,286 |  | (1,536,499) | (10)
Balance (in shares) at Dec. 31, 2019 |  |  | 89,682 |  |  |  |  |
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] |  |  |  |  |  |  |  |
Net loss | (128,218) |  |  |  |  |  | (128,218) |
Other comprehensive income (loss) | (88) |  |  |  |  |  |  | (88)
Exercise of stock options and ESPP shares (in shares) |  |  |  | 472 |  |  |  |
Exercise of stock options and ESPP shares |  | 7,567 |  | $ 5 |  | 7,562 |  |
Net proceeds from issuance of common stock | 245,912 |  | $ 111 |  | 245,801 |  |  |
Net proceeds from issuance of common stock (in shares) |  |  | 11,155 |  |  |  |  |
Issuance of common stock for vesting of RSUs | 1 |  | $ 1 |  |  |  |  |
Issuance of common stock for vesting of RSUs (in shares) |  |  | 125 |  |  |  |  |
Stock compensation expense | 18,470 |  |  |  | 18,470 |  |  |
Balance at Jun. 30, 2020 | 405,318 |  | $ 1,014 |  | 2,069,119 |  | (1,664,717) | (98)
Balance (in shares) at Jun. 30, 2020 |  |  | 101,434 |  |  |  |  |
Balance at Mar. 31, 2020 | 206,701 |  | $ 899 |  | 1,808,712 |  | (1,602,863) | (47)
Balance (in shares) at Mar. 31, 2020 |  |  | 89,860 |  |  |  |  |
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] |  |  |  |  |  |  |  |
Net loss | (61,854) |  |  |  |  |  | (61,854) |
Other comprehensive income (loss) | (51) |  |  |  |  |  |  | (51)
Exercise of stock options and ESPP shares (in shares) |  |  |  | 321 |  |  |  |
Exercise of stock options and ESPP shares |  | $ 5,141 |  | $ 3 |  | $ 5,138 |  |
Net proceeds from issuance of common stock | 245,912 |  | $ 111 |  | 245,801 |  |  |
Net proceeds from issuance of common stock (in shares) |  |  | 11,155 |  |  |  |  |
Issuance of common stock for vesting of RSUs | 1 |  | $ 1 |  |  |  |  |
Issuance of common stock for vesting of RSUs (in shares) |  |  | 98 |  |  |  |  |
Stock compensation expense | 9,468 |  |  |  | 9,468 |  |  |
Balance at Jun. 30, 2020 | $ 405,318 |  | $ 1,014 |  | $ 2,069,119 |  | $ (1,664,717) | $ (98)
Balance (in shares) at Jun. 30, 2020 |  |  | 101,434 |  |  |  |  |

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