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Consolidated Statements of Shareholders' Equity (unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Stock Options and ESPP Shares
Common Stock
Common Stock
Stock Options and ESPP Shares
Additional Paid-in Capital
Additional Paid-in Capital
Stock Options and ESPP Shares
Accumulated Deficit
Accumulated Other Comprehensive Loss
Balance at Dec. 31, 2018 $ 208,266   $ 773   $ 1,489,664   $ (1,282,162) $ (9)
Balance (in shares) at Dec. 31, 2018     77,308          
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]                
Net loss (140,667)           (140,667)  
Other comprehensive income (loss) 2             2
Exercise of stock options and ESPP shares (in shares)       1,163        
Exercise of stock options and ESPP shares   $ 13,504   $ 11   $ 13,493    
Net proceeds from issuance of common stock 261,178   $ 107   261,071      
Net proceeds from issuance of common stock (in shares)     10,658          
Issuance of common stock for vesting of RSUs 1   $ 1          
Issuance of common stock for vesting of RSUs (in shares)     78          
Stock compensation expense 14,289       14,289      
Balance at Jun. 30, 2019 356,573   $ 892   1,778,517   (1,422,829) (7)
Balance (in shares) at Jun. 30, 2019     89,207          
Balance at Mar. 31, 2019 144,137   $ 776   1,499,646   (1,356,315) 30
Balance (in shares) at Mar. 31, 2019     77,596          
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]                
Net loss (66,514)           (66,514)  
Other comprehensive income (loss) (37)             (37)
Exercise of stock options and ESPP shares (in shares)       910        
Exercise of stock options and ESPP shares   10,455   $ 8   10,447    
Net proceeds from issuance of common stock 261,178   $ 107   261,071      
Net proceeds from issuance of common stock (in shares)     10,658          
Issuance of common stock for vesting of RSUs 1   $ 1          
Issuance of common stock for vesting of RSUs (in shares)     43          
Stock compensation expense 7,353       7,353      
Balance at Jun. 30, 2019 356,573   $ 892   1,778,517   (1,422,829) (7)
Balance (in shares) at Jun. 30, 2019     89,207          
Balance at Dec. 31, 2019 261,674   $ 897   1,797,286   (1,536,499) (10)
Balance (in shares) at Dec. 31, 2019     89,682          
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]                
Net loss (128,218)           (128,218)  
Other comprehensive income (loss) (88)             (88)
Exercise of stock options and ESPP shares (in shares)       472        
Exercise of stock options and ESPP shares   7,567   $ 5   7,562    
Net proceeds from issuance of common stock 245,912   $ 111   245,801      
Net proceeds from issuance of common stock (in shares)     11,155          
Issuance of common stock for vesting of RSUs 1   $ 1          
Issuance of common stock for vesting of RSUs (in shares)     125          
Stock compensation expense 18,470       18,470      
Balance at Jun. 30, 2020 405,318   $ 1,014   2,069,119   (1,664,717) (98)
Balance (in shares) at Jun. 30, 2020     101,434          
Balance at Mar. 31, 2020 206,701   $ 899   1,808,712   (1,602,863) (47)
Balance (in shares) at Mar. 31, 2020     89,860          
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]                
Net loss (61,854)           (61,854)  
Other comprehensive income (loss) (51)             (51)
Exercise of stock options and ESPP shares (in shares)       321        
Exercise of stock options and ESPP shares   $ 5,141   $ 3   $ 5,138    
Net proceeds from issuance of common stock 245,912   $ 111   245,801      
Net proceeds from issuance of common stock (in shares)     11,155          
Issuance of common stock for vesting of RSUs 1   $ 1          
Issuance of common stock for vesting of RSUs (in shares)     98          
Stock compensation expense 9,468       9,468      
Balance at Jun. 30, 2020 $ 405,318   $ 1,014   $ 2,069,119   $ (1,664,717) $ (98)
Balance (in shares) at Jun. 30, 2020     101,434