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Consolidated Statements of Comprehensive Loss (unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Statement of Comprehensive Income [Abstract]        
Product revenues, net $ 45,366 $ 42,495 $ 85,580 $ 79,355
Operating expenses:        
Cost of product revenues (excluding amortization of intangible assets) $ 10,837 $ 9,950 $ 20,681 $ 18,388
Cost, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Research and development $ 64,655 $ 35,748 $ 126,045 $ 71,932
Selling, general and administrative 57,177 49,663 108,727 101,009
Amortization of intangible assets 1,263 1,248 2,526 2,497
Total operating expenses 133,932 96,609 257,979 193,826
Operating loss (88,566) (54,114) (172,399) (114,471)
Investment income 34 203 67 1,607
Interest expense (10,319) (7,469) (17,878) (14,880)
Loss on extinguishment of debt (17,689) 0 (17,689) 0
Other expense, net (159) (46) (202) (10)
Loss before income taxes (116,699) (61,426) (208,101) (127,754)
Provision for income taxes 622 428 861 464
Net loss $ (117,321) $ (61,854) $ (208,962) $ (128,218)
Basic net loss per share (in dollars per share) $ (1.07) $ (0.64) $ (1.97) $ (1.38)
Diluted net loss per share (in dollars per share) $ (1.07) $ (0.64) $ (1.97) $ (1.38)
Weighted average basic common shares outstanding (in shares) 109,580 96,633 106,328 93,206
Weighted average diluted common shares outstanding (in shares) 109,580 96,633 106,328 93,206
Net loss $ (117,321) $ (61,854) $ (208,962) $ (128,218)
Other comprehensive income (loss):        
Foreign currency translation income (loss) 334 (51) 231 (88)
Total comprehensive loss $ (116,987) $ (61,905) $ (208,731) $ (128,306)
Revenue from Contract with Customer, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember