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Consolidated Statements of Shareholders' Equity (unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Balance (in shares) at Dec. 31, 2019   89,682      
Balance at Dec. 31, 2019 $ 261,674 $ 897 $ 1,797,286 $ (1,536,499) $ (10)
Comprehensive loss:          
Net loss (128,218)     (128,218)  
Other comprehensive income (loss) (88)       (88)
Exercise of stock options and ESPP shares issuance (in shares)   472      
Exercise of stock options and ESPP shares issuance 7,567 $ 5 7,562    
Net proceeds from issuance of common stock (in shares)   11,155      
Net proceeds from issuance of common stock 245,912 $ 111 245,801    
Issuance of common stock for vesting of RSUs (in shares)   125      
Issuance of common stock for vesting of RSUs 1 $ 1      
Stock-based compensation expense 18,470   18,470    
Balance (in shares) at Jun. 30, 2020   101,434      
Balance at Jun. 30, 2020 405,318 $ 1,014 2,069,119 (1,664,717) (98)
Balance (in shares) at Mar. 31, 2020   89,860      
Balance at Mar. 31, 2020 206,701 $ 899 1,808,712 (1,602,863) (47)
Comprehensive loss:          
Net loss (61,854)     (61,854)  
Other comprehensive income (loss) (51)       (51)
Exercise of stock options and ESPP shares issuance (in shares)   321      
Exercise of stock options and ESPP shares issuance 5,141 $ 3 5,138    
Net proceeds from issuance of common stock (in shares)   11,155      
Net proceeds from issuance of common stock 245,912 $ 111 245,801    
Issuance of common stock for vesting of RSUs (in shares)   98      
Issuance of common stock for vesting of RSUs 1 $ 1      
Stock-based compensation expense 9,468   9,468    
Balance (in shares) at Jun. 30, 2020   101,434      
Balance at Jun. 30, 2020 405,318 $ 1,014 2,069,119 (1,664,717) (98)
Balance (in shares) at Dec. 31, 2020   102,763      
Balance at Dec. 31, 2020 275,884 $ 1,028 2,105,252 (1,830,589) 193
Comprehensive loss:          
Net loss (208,962)     (208,962)  
Other comprehensive income (loss) 231       231
Exercise of stock options and ESPP shares issuance (in shares)   760      
Exercise of stock options and ESPP shares issuance 13,525 $ 7 13,518    
Net proceeds from issuance of common stock (in shares)   11,500      
Net proceeds from issuance of common stock 269,886 $ 115 269,771    
Equity component of convertible debt issuance 196,063   196,063    
Equity component of convertible debt redemption (37,846)   (37,846)    
Issuance of common stock for vesting of RSUs (in shares)   216      
Issuance of common stock for vesting of RSUs 2 $ 2      
Stock-based compensation expense 22,270   22,270    
Balance (in shares) at Jun. 30, 2021   115,239      
Balance at Jun. 30, 2021 531,053 $ 1,152 2,569,028 (2,039,551) 424
Balance (in shares) at Mar. 31, 2021   103,279      
Balance at Mar. 31, 2021 201,636 $ 1,033 2,122,743 (1,922,230) 90
Comprehensive loss:          
Net loss (117,321)     (117,321)  
Other comprehensive income (loss) 334       334
Exercise of stock options and ESPP shares issuance (in shares)   344      
Exercise of stock options and ESPP shares issuance 6,565 $ 3 6,562    
Net proceeds from issuance of common stock (in shares)   11,500      
Net proceeds from issuance of common stock   $ 115 269,771    
Equity component of convertible debt issuance 196,063   196,063    
Equity component of convertible debt redemption (37,846)   (37,846)    
Issuance of common stock for vesting of RSUs (in shares)   116      
Issuance of common stock for vesting of RSUs 1 $ 1      
Stock-based compensation expense 11,735   11,735    
Balance (in shares) at Jun. 30, 2021   115,239      
Balance at Jun. 30, 2021 $ 531,053 $ 1,152 $ 2,569,028 $ (2,039,551) $ 424