<SEC-DOCUMENT>0001140361-21-011236.txt : 20210401
<SEC-HEADER>0001140361-21-011236.hdr.sgml : 20210401
<ACCEPTANCE-DATETIME>20210401161229
ACCESSION NUMBER:		0001140361-21-011236
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		8
CONFORMED PERIOD OF REPORT:	20210512
FILED AS OF DATE:		20210401
DATE AS OF CHANGE:		20210401

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INSMED Inc
		CENTRAL INDEX KEY:			0001104506
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				541972729
		STATE OF INCORPORATION:			VA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30739
		FILM NUMBER:		21798110

	BUSINESS ADDRESS:	
		STREET 1:		700 US HIGHWAY 202/206
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807
		BUSINESS PHONE:		908-977-9900

	MAIL ADDRESS:	
		STREET 1:		700 US HIGHWAY 202/206
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INSMED INC
		DATE OF NAME CHANGE:	20000128
</SEC-HEADER>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>UNITED STATES</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Washington, D.C. 20549</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 13pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>SCHEDULE 14A</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Proxy Statement Pursuant to Section&#160;14(a) of&#160;<br>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Amendment No. &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;)</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>NOTICE OF MEETING</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>and</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>PROXY STATEMENT</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>for</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>ANNUAL MEETING OF SHAREHOLDERS</b></p>
  <p style="font: 25pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>&#160;</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>MAY 12, 2021</b></p>
  <p style="font: 40pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><img src="nc10021629x1_img01.jpg" alt="" height="139" border="0" width="400"></p>
  <p style="font: 70pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>700 US Highway 202/206<br>
      Bridgewater, New Jersey 08807</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Insmed Incorporated<br>
      700 US Highway 202/206<br>
      Bridgewater, New Jersey 08807<br>
      (908)&#160;977-9900</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">April 1, 2021</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">To Our Shareholders:</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We cordially invite you to attend the 2021 Annual Meeting of Shareholders of Insmed Incorporated (Insmed), which, in light of the COVID-19 pandemic and related public
    health concerns, will be held virtually via the Internet at www.virtualshareholdermeeting.com/INSM2021 on May&#160;12, 2021, at 9:00&#160;a.m. Eastern time (the Annual Meeting). A formal notice of the Annual Meeting accompanies this letter. At the Annual
    Meeting, the following items will be submitted to a shareholder vote:</p>
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        <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.</font></td>
        <td>election of four Class&#160;III directors, David R. Brennan, Leo Lee, Carol A. Schafer, and Melvin Sharoky, M.D., to serve until the 2024 Annual Meeting of Shareholders;</td>
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        <td style="width: 0.5in">2.</td>
        <td>an advisory vote on the 2020 compensation of our named executive officers;</td>
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        <td style="width: 0.5in">3.</td>
        <td>ratification of the appointment of Ernst&#160;&amp; Young&#160;LLP as our independent registered public accounting firm for the year ending December&#160;31, 2021;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td style="width: 0.5in">4.</td>
        <td>approval of an amendment to the Insmed Incorporated 2019 Incentive Plan; and</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td style="width: 0.5in">5.</td>
        <td>transaction of such other business as may properly come before the Annual Meeting or any adjournment or postponement thereof.</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Your vote is important, and the company encourages you to vote. Please read the notice and proxy materials carefully, and vote promptly in advance of the meeting by
    telephone, electronically through the Internet, or by returning a completed proxy card by mail. You may also attend the Annual Meeting and vote and submit questions during the Annual Meeting via the Internet at
    www.virtualshareholdermeeting.com/INSM2021. Whether or not you plan to attend the Annual Meeting and regardless of the number of shares of Insmed common stock you own, please vote by proxy prior to the Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <td style="width: 50%; padding-left: 10pt; text-indent: -10pt">&#160;</td>
        <td style="padding-left: 1.5pt; width: 50%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sincerely yours,</font></td>
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        <td style="border-bottom: Black 1pt solid; padding-left: 1.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ <font style="font-variant: small-caps">William H. Lewis</font></font></td>
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        <td style="padding-left: 1.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">William H. Lewis<br>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This Proxy Statement is first being mailed to shareholders on or about April 1, 2021.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>INSMED INCORPORATED</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>700 US Highway 202/206</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Bridgewater, New Jersey 08807</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>(908)&#160;977-9900</b></p>
  <p style="font: 15pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>NOTICE OF ANNUAL MEETING OF SHAREHOLDERS</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>TO BE HELD ON MAY 12, 2021</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">NOTICE IS HEREBY GIVEN that the 2021 Annual Meeting of Shareholders of Insmed Incorporated (Insmed) will be held virtually via the Internet at
    www.virtualshareholdermeeting.com/INSM2021, on May&#160;12, 2021, at 9:00&#160;a.m. Eastern time (the Annual Meeting), and at any adjournment or postponement thereof, for the following purposes:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">1.</td>
        <td>To elect four Class&#160;III directors, David R. Brennan, Leo Lee, Carol A. Schafer, and Melvin Sharoky, M.D., to serve until the 2024 Annual Meeting of Shareholders;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">2.</td>
        <td>To conduct an advisory vote on the 2020 compensation of our named executive officers;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">3.</td>
        <td>To ratify the appointment of Ernst&#160;&amp; Young&#160;LLP as our independent registered public accounting firm for the year ending December&#160;31, 2021;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">4.</td>
        <td>To approve an amendment to the Insmed Incorporated 2019 Incentive Plan; and</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">5.</td>
        <td>To transact such other business as may properly come before the Annual Meeting or any adjournment or postponement thereof.</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Due to the COVID-19 pandemic and public health concerns, the Annual Meeting will be a completely virtual meeting of shareholders. Holders of record of shares of Insmed
    common stock at the close of business on March&#160;19, 2021 will be entitled to vote at the Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">You are requested to vote promptly in advance of the Annual Meeting by telephone by dialing 1-800-690-6903, electronically through the Internet by visiting
    www.proxyvote.com, or by returning a completed proxy card by mail regardless of whether you expect to attend the Annual Meeting. If you attend the Annual Meeting, you may vote even if you already have sent in your proxy. If you are a beneficial owner,
    you may not vote your shares at the Annual Meeting unless you enter the 16-digit control number found on your notice, proxy card or other proxy materials.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 50%; padding-left: 10pt; text-indent: -10pt">&#160;</td>
        <td style="width: 50%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">By Order of the Board</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-left: 10pt; text-indent: -10pt">&#160;</td>
        <td>&#160;</td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-left: 10pt; text-indent: -10pt">&#160;</td>
        <td style="border-bottom: Black 1pt solid"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ CHRISTINE PELLIZZARI</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-left: 10pt; text-indent: -10pt">&#160;</td>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Christine Pellizzari<br>
            <i>Corporate Secretary</i></font></td>
      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">April 1, 2021</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE INSMED INCORPORATED ANNUAL MEETING OF SHAREHOLDERS TO BE HELD ON MAY 12, 2021: The Proxy Statement and Annual
      Report on Form&#160;10-K for the year ended December&#160;31, 2020 are available at&#160;<font style="border-bottom: Black 1pt solid">www.proxyvote.com</font></b><b>.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
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          <td style="text-align: center; width: 100%">&#160;</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>PROXY STATEMENT<br>
      for<br>
      ANNUAL MEETING OF SHAREHOLDERS<br>
    </b>&#160;<b>of<br>
      INSMED INCORPORATED<br>
      To be held May&#160;12, 2021<br>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>&#160;</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Table of Contents</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: bottom">
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; text-align: center; padding-bottom: 1pt">&#160;</td>
        <td style="padding-top: 2pt; border-bottom: Black 1pt solid; width: 25pt; text-align: center; padding-bottom: 1pt"><font style="font-size: 8pt"><b>Page</b></font></td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a001">GENERAL INFORMATION ABOUT THE ANNUAL MEETING AND VOTING</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">1</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a002">PROPOSAL NO. 1 ELECTION OF CLASS III DIRECTORS</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">5</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a003">CORPORATE GOVERNANCE</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">15</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a004">AUDIT COMMITTEE REPORT AND INDEPENDENT AUDITOR FEES</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">22</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a005">CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">23</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a006">DELINQUENT SECTION&#160;16(a) REPORTS</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">24</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a007">SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS, DIRECTORS AND MANAGEMENT</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">24</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a008">PROPOSAL NO. 2 ADVISORY VOTE ON THE 2020 COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">27</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a009">COMPENSATION DISCUSSION AND ANALYSIS</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">28</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a010">COMPENSATION COMMITTEE REPORT</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">40</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a011">COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">47</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a012">DODD-FRANK MANDATED PAY RATIO DISCLOSURE</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">47</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 20pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a013">DIRECTOR COMPENSATION</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">48</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a014">PROPOSAL NO. 3 RATIFICATION OF THE APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">49</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a015">PROPOSAL NO. 4 AMENDMENT NO. 2 TO THE INSMED INCORPORATED 2019 INCENTIVE PLAN</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">50</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a016">PROPOSALS FOR 2022 ANNUAL MEETING</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">58</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a017">ANNUAL REPORT ON FORM 10-K</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">59</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a018">SEPARATE COPIES FOR BENEFICIAL HOLDERS</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">59</td>
      </tr>
      <tr>
        <td style="text-indent: -10pt; padding-left: 10pt; padding-top: 2pt; vertical-align: top; padding-bottom: 1pt"><a href="#a019">APPENDIX A: AMENDMENT NO. 2 TO INSMED INCORPORATED 2019 INCENTIVE PLAN</a></td>
        <td style="padding-top: 2pt; vertical-align: bottom; text-align: right; padding-bottom: 1pt">A-1</td>
      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In this Proxy Statement, we use the words &#8220;Insmed Incorporated&#8221; to refer to Insmed Incorporated, a Virginia corporation, and we use the words &#8220;Company,&#8221; &#8220;Insmed,&#8221; &#8220;we,&#8221; &#8220;us&#8221; and &#8220;our&#8221; to
    refer to Insmed Incorporated and its consolidated subsidiaries. Insmed and ARIKAYCE are trademarks of Insmed Incorporated. This Proxy Statement also contains trademarks of third parties. Each trademark of another company appearing in this Proxy
    Statement is the property of its owner.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
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        <tr style="vertical-align: top; text-align: left">
          <td style="text-align: center; width: 100%">&#160;</td>
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    </table>
  </div>
  <div style="page-break-before:always; margin-top: 6pt; margin-bottom: 12pt">
    <p style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt"></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>PROXY STATEMENT<br>
      for<br>
      ANNUAL MEETING OF SHAREHOLDERS<br>
      of<br>
      INSMED INCORPORATED<br>
      To be held May&#160;12, 2021</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a001"></a>GENERAL INFORMATION ABOUT THE ANNUAL MEETING AND VOTING</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Distribution of Proxy Solicitation and Other Required Annual Meeting Materials</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Board of Directors (the Board) of Insmed Incorporated is soliciting your proxy for the Annual Meeting of Shareholders on May&#160;12, 2021, at 9:00&#160;a.m. Eastern time
    (the Annual Meeting), and any adjournment or postponement thereof. Due to the COVID-19 pandemic and related public health concerns, the Annual Meeting will be held virtually via the Internet at www.virtualshareholdermeeting.com/INSM2021. We intend to
    make the Proxy Statement and related proxy materials available to our shareholders on or about April 1, 2021.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Information about the Annual Meeting and Voting at or Prior to the Annual Meeting</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Why Did I Receive a One-page Notice in the Mail Regarding the Internet Availability of Proxy Materials Instead of a Full Set of Proxy Materials?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to rules adopted by the SEC, we have elected to mail to many of our shareholders a Notice of Internet Availability of the Proxy Materials (the Notice) instead
    of a paper copy of the proxy materials. All shareholders receiving the Notice will have the ability to access the proxy materials over the Internet and receive a paper copy of the proxy materials by mail on request. Instructions on how to access the
    proxy materials over the Internet or to request a paper copy may be found in the Notice. In addition, the Notice contains instructions on how you may request proxy materials in printed form by mail or electronically on an ongoing basis. This process
    has allowed us to expedite our shareholders&#8217; receipt of proxy materials, lower the costs of distribution and reduce the environmental impact of our Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Who May Vote Shares in Connection with the Annual Meeting?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Shareholders of record at the close of business on March&#160;19, 2021 (the Record Date), will be entitled to notice of and to vote at the Annual Meeting. As of the Record
    Date, we had 103,270,236 outstanding shares of our common stock, $0.01 par value per share (the Common Stock). Each share of our Common Stock entitles the holder to one vote with respect to all matters submitted to shareholders at the Annual Meeting.
    Beneficial owners of shares of our Common Stock may direct the record holder of the shares on how to vote the shares held on their behalf.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Who May Participate in the Annual Meeting?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This year&#8217;s Annual Meeting will take place virtually through the Internet, in light of the COVID-19 pandemic and related public health concerns. We have designed the
    format of this year&#8217;s Annual Meeting to ensure that our shareholders who attend the Annual Meeting will be afforded the same rights and opportunities to participate as they would at an in-person meeting. You are entitled to attend and participate in
    the Annual Meeting only if you were a shareholder of record as of the close of business on the Record Date, or if you hold a valid proxy for the meeting, as described below. To be admitted to the Annual Meeting at
    www.virtualshareholdermeeting.com/INSM2021, you must enter the 16-digit control number found on your notice, proxy card or other proxy materials. If you do not have a control number, please contact the brokerage firm, bank, dealer, or other similar
    organization that holds your account as soon as possible so that you can be provided with a control number.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What is a Shareholder of Record and How Can I Vote if I am a Shareholder of Record?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If, as of the close of business on the Record Date, shares of our Common Stock were registered directly in your name with our transfer agent, then you are a
    shareholder of record. As a shareholder of record, you may vote by proxy in advance or at the Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If you are a shareholder of record, you may vote or submit a proxy as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

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        <td><i>By Internet</i>&#8212;</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Before the Annual Meeting</i></font>&#8212;You may authorize the voting of your shares by following the
    &#8220;Vote by Internet&#8221; instructions set forth on the Notice or proxy card through 11:59&#160;p.m. Eastern Time on Tuesday, May&#160;11, 2021. You must specify how you want your shares voted or your vote will not be completed and you will receive an error message.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>During the Annual Meeting</i></font>&#8212;You may vote online during the Annual Meeting. You may cast
    your vote electronically during the Annual Meeting using the 16-digit control number found on your notice or proxy card or other proxy materials and following the instructions at www.virtualshareholdermeeting.com/INSM2021.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in">&#160;</p>
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        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">2.</td>
        <td><i>By Telephone</i>&#8212;Dial 1-800-690-6903 using any touch-tone phone to transmit your voting instructions through 11:59&#160;p.m. Eastern Time on Tuesday, May&#160;11, 2021. Have your notice, proxy card or other proxy materials in hand when you call and
          follow the voting instructions given to you over the phone.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">3.</td>
        <td><i>By Mail</i>&#8212;Complete and sign the proxy card and mail it in accordance with the instructions on the proxy card. Completed proxy cards must be received by 11:59&#160;p.m. Eastern Time on Tuesday, May&#160;11, 2021.</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In all cases, your shares will be voted according to your instructions.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What is a Beneficial Owner of Shares and How Can I Vote if I am a Beneficial Owner?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If, on the Record Date, your shares of our Common Stock were not held in your name with our transfer agent, but instead were held in an account at a brokerage firm,
    bank, dealer, or other similar organization, then you are the beneficial owner of shares held in &#8220;street name,&#8221; and these proxy materials have been forwarded to you by that organization. The organization holding your account is considered to be the
    shareholder of record of shares of our Common Stock for purposes of voting at the Annual Meeting and is required to vote those shares in accordance with your instructions. If you do not give instructions to the organization holding your account, then
    the organization will have discretion to vote the shares with respect to &#8220;routine&#8221; matters but will not be permitted to vote the shares with respect to &#8220;non-routine&#8221; matters. See &#8220;What Matters at the Annual Meeting are &#8216;Routine&#8217; and &#8216;Non-Routine&#8217;?&#8221;
    below. As a beneficial owner, you are invited to attend the Annual Meeting via the Internet at www.virtualshareholdermeeting.com/INSM2021. If you are a beneficial owner, you may not vote your shares at the Annual Meeting unless you enter the 16-digit
    control number found on your notice, proxy card or other proxy materials.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What if I Need Technical Assistance During the Annual Meeting?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We encourage you to access the Annual Meeting before it begins. Online check-in will start shortly before the meeting on May&#160;12, 2021. If you encounter any
    difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support number that will be posted on the virtual Annual Meeting log-in page.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What is the Quorum Requirement? </i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">A quorum of shareholders is necessary to hold the Annual Meeting. Shares of our Common Stock representing a majority of the votes entitled to be cast on a matter at
    the Annual Meeting (or 51,635,119 shares as of the Record Date) will constitute a quorum for the transaction of business with respect to such matter, unless otherwise provided by law or in our Articles of Incorporation, as amended (Articles of
    Incorporation). Votes withheld, abstentions and broker non-votes count as present for establishing a quorum.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What Matters at the Annual Meeting are &#8220;Routine&#8221; and &#8220;Non-Routine&#8221;?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Proposal 1, the election of Class&#160;III directors, Proposal 2, the advisory vote on the 2020 compensation of our named executive officers, and Proposal 4, the approval
    of an amendment to the Insmed Incorporated 2019 Incentive Plan (the 2019 Incentive Plan), are non-routine matters. Proposal 3, the ratification of the appointment of our independent registered public accounting firm, is a routine matter. If you are a
    beneficial owner of shares of our Common Stock and do not instruct your broker or other agent how to vote, your shares will not be voted on &#8220;non-routine&#8221; matters and your shares will be &#8220;broker non-votes&#8221; with respect to those proposals.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What are the Voting Requirements to Approve Each Proposal to be Submitted to Shareholders?</i></b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The vote required to elect directors and approve each of the matters scheduled for a vote at the Annual Meeting is set forth below:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid; padding-top: 2pt; text-align: center"><font style="font-size: 8pt"><b>Vote Required</b></font></td>
        <td style="padding-bottom: 1pt">&#160;</td>
        <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid; padding-top: 2pt; text-align: center"><font style="font-size: 8pt"><b>Board Recommendation</b></font></td>
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        <td style="padding-top: 2pt; width: 2%; padding-bottom: 1pt">1.&#160;&#160;&#160;&#160;</td>
        <td style="text-align: left; padding-top: 2pt; width: 52%; padding-bottom: 1pt">Election of four Class&#160;III directors</td>
        <td style="width: 1%">&#160;</td>
        <td style="padding-top: 2pt; width: 22%; padding-bottom: 1pt">Plurality of votes cast</td>
        <td style="width: 1%">&#160;</td>
        <td style="padding-top: 2pt; text-align: center; width: 22%; padding-bottom: 1pt"><b>FOR</b></td>
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      <tr style="vertical-align: top">
        <td style="padding-top: 2pt; padding-bottom: 1pt">2.</td>
        <td style="text-align: left; padding-top: 2pt; padding-bottom: 1pt">Advisory vote to approve the 2020 compensation of our named executive officers</td>
        <td>&#160;</td>
        <td style="padding-top: 2pt; padding-bottom: 1pt">Majority of votes cast</td>
        <td>&#160;</td>
        <td style="padding-top: 2pt; text-align: center; padding-bottom: 1pt"><b>FOR</b></td>
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        <td style="padding-top: 2pt; padding-bottom: 1pt">3.</td>
        <td style="text-align: left; padding-top: 2pt; padding-bottom: 1pt">Ratification of appointment of Ernst&#160;&amp; Young&#160;LLP (Ernst&#160;&amp; Young) as our independent registered public accounting firm for the year ending December&#160;31, 2021</td>
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        <td style="padding-top: 2pt; padding-bottom: 1pt">Majority of votes cast</td>
        <td>&#160;</td>
        <td style="padding-top: 2pt; text-align: center; padding-bottom: 1pt"><b>FOR</b></td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-top: 2pt; padding-bottom: 1pt">4.</td>
        <td style="text-align: left; padding-top: 2pt; padding-bottom: 1pt">Approval of an amendment to the 2019 Incentive Plan</td>
        <td>&#160;</td>
        <td style="padding-top: 2pt; padding-bottom: 1pt">Majority of votes cast</td>
        <td>&#160;</td>
        <td style="padding-top: 2pt; text-align: center; padding-bottom: 1pt"><b>FOR</b></td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Proposal 1, the election of Class&#160;III directors, requires a plurality of the votes cast. This means that the four nominees who receive the highest number of
    affirmative votes cast will be elected irrespective of how small the number of affirmative votes is in comparison to the total number of shares voted. Our Board, however, has adopted a director resignation policy, under which a director nominee in an
    uncontested election must submit his or her resignation for consideration by our Nominations and Governance Committee of the Board (the Nominations and Governance Committee) and our Board if the number of votes withheld with respect to such director&#8217;s
    election exceeds the number of votes &#8220;for&#8221; such director&#8217;s election. See &#8220;Corporate Governance&#8212;Corporate Governance Matters&#8212;Director Resignation Policy&#8221; for additional information.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Proposal 2, the advisory vote on the 2020 compensation of our named executive officers, is not binding on, nor does it overrule, any decisions of the Company, the
    Board or the Compensation Committee of the Board (the Compensation Committee). We value the input of our shareholders, and in the event that Proposal 2 is not approved by a majority of votes cast, the Board and the Compensation Committee will consider
    our shareholders&#8217; concerns and evaluate what actions, if any, may be appropriate to address those concerns.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Proposal 3, the ratification of the appointment of Ernst&#160;&amp; Young as our independent registered public accounting firm for the year ending December&#160;31, 2021, does
    not require shareholder ratification under Virginia law, our Articles of Incorporation, or our Amended and Restated Bylaws (Bylaws). However, the Board is submitting the appointment of Ernst&#160;&amp; Young to the shareholders for ratification as a matter
    of good corporate governance. In the event that Proposal 3 is not approved by a majority of votes cast, the Audit Committee will consider the vote in future independent auditor selection decisions.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Proposal 4, the approval of an amendment to the 2019 Incentive Plan, requires the affirmative vote of a majority of the votes cast at the Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What Is the Effect of Votes Withheld, Abstentions and Broker Non-Votes On Each of the Proposals?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Votes that are withheld or any abstentions from voting will not be counted in determining the number of votes cast with respect to any of the proposals. As explained
    above, because Proposals 1, 2 and 4 are considered &#8220;non-routine,&#8221; if a beneficial owner does not instruct its broker or other agent how to vote such beneficial owner&#8217;s shares, broker non-votes will result. Broker non-votes will not be counted in
    determining the number of votes cast with respect to these proposals. Because Proposal 3 is considered &#8220;routine,&#8221; a beneficial owner&#8217;s broker or other agent will have discretion to vote any shares with respect to which such beneficial owner does not
    provide instructions, and no broker non-votes will occur with respect to this proposal.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What if I Submit a Proxy But Do Not Specify How I Would Like to Vote?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If we receive a signed and dated proxy card or receive your instructions by Internet or by telephone and your instructions do not specify how your shares are to be
    voted, your shares will be voted as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.25in">&#8226;</td>
        <td>FOR the election of each of the four Class&#160;III nominees for director;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.25in">&#8226;</td>
        <td>FOR the approval of the 2020 compensation of our named executive officers;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.25in">&#8226;</td>
        <td>FOR the ratification of the appointment of Ernst&#160;&amp; Young as our independent registered public accounting firm for the year ending December&#160;31, 2021; and</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.25in">&#8226;</td>
        <td>FOR the approval of an amendment to the 2019 Incentive Plan.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unsigned proxy cards will not be voted.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <tr style="vertical-align: top; text-align: left">
          <td style="width: 33%">&#160;</td>
          <td style="text-align: center; width: 34%">&#160;<!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></td>
          <td style="width: 33%">&#160;</td>
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    </table>
  </div>
  <div style="page-break-before:always; margin-top: 6pt; margin-bottom: 12pt">
    <p style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt"></p>
  </div>
  <!-- Field: /Page -->
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What If Other Matters Not Described Herein Are Brought Before the Annual Meeting for Action by the Shareholders?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of the date of this Proxy Statement, the Board does not intend to present any matters other than those described herein at the Annual Meeting and is not aware of
    any matters to be presented by other parties. If other matters are properly brought before the Annual Meeting, or any adjournment or postponement thereof, for action by the shareholders, proxies will be voted in accordance with the recommendation of
    the Board or, in the absence of such a recommendation, in accordance with the judgment of the proxy holders.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>How Can I Revoke a Proxy Once I Have Voted?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Anyone giving a proxy may revoke it at any time before it is exercised by voting at the Annual Meeting or by delivering, including by phone or Internet, a later dated
    proxy or written notice of revocation to our Corporate Secretary. Attendance at the Annual Meeting will not itself revoke a proxy. A proxy, if executed, properly delivered and not revoked, will be voted at the Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>What is the Expected Cost of Soliciting Proxies and Who Will Pay for this Cost?</i></b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We will pay the cost of soliciting proxies. In addition to the use of mail and e-mail, proxies may be solicited in person or by telephone by our employees, with no
    additional remuneration. We have engaged The Proxy Advisory Group,&#160;LLC to assist in the solicitation of proxies and provide related advice and informational support, for a service fee, plus customary disbursements, which are not expected to exceed
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif"></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif"><b></b></font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><u>Executive Officers</u></b></font></p>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: right">52</td>
        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">President and CEO</td>
        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">September 2012&#8212;Present</td>
      </tr>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: right">40</td>
        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">January 2020&#8212;Present</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">October 2019&#8212;Present</td>
      </tr>
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        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">July 2013&#8212;Present</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">January 2013&#8212;Present</td>
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        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: right">59</td>
        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">Chief Compliance Officer</td>
        <td>&#160;</td>
        <td style="vertical-align: bottom; text-align: center">January 2018&#8212;Present</td>
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      Incorporated, positions she held since May 2018. From February 2014 to April 2018, Ms.&#160;Bonstein served as the Chief Financial Officer, Secretary, Treasurer and Executive Vice President at Advaxis,&#160;Inc. Prior to Advaxis, Ms.&#160;Bonstein was a Six Sigma
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      September 2016 and was promoted to Chief Operating Officer in November 2019. Mr.&#160;Adsett has over 20&#160;years of experience in the global biotechnology and pharmaceutical industry. From January 2015 to September 2016, Mr.&#160;Adsett was Senior Vice
      President, Head of Gastrointestinal and Internal Medicine Business Unit at Shire&#160;Plc (Shire), a global specialty biopharmaceutical company. From August 2008 to January 2015, Mr.&#160;Adsett was Senior Vice President, Gastrointestinal Business Unit Leader
      at Shire. From October 2005 to August 2008, Mr.&#160;Adsett was General Manager, Oral IBD Products of the Gastroenterology Business Unit of Shire. From November 1994 to October 2005, Mr.&#160;Adsett held various marketing and commercial roles at
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      Senior Vice President at Boehringer Ingelheim International. From 2012 to 2018, Dr.&#160;Flammer held various positions at Boehringer Ingelheim, including Vice President, Clinical Development and Medical Affairs (2016&#160;-&#160;2018), Vice President of Medicine,
      Regulatory Affairs&#160;&amp; Pharmacovigilance (2014&#160;-&#160;2016), and Senior Global Medical Director, Clinical Development&#160;&amp; Medical Affairs Virology (2012&#160;-&#160;2014). Prior to her time at Boehringer Ingelheim, Dr.&#160;Flammer served in various roles at
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      in 2007. Prior to her tenure at Dendrite, Ms.&#160;Pellizzari practiced law at the firm of Wilentz, Goldman&#160;&amp; Spitzer where she specialized in health care transactions and related regulatory matters. Before joining Wilentz, Ms.&#160;Pellizzari served as a
      law clerk to the Honorable Reginald Stanton, Assignment Judge for the Superior Court of New Jersey. Ms.&#160;Pellizzari received her Bachelor of Arts degree, cum laude, from the University of Massachusetts, Amherst and her Juris Doctor degree from the
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      in human resources, organizational development, corporate operations, and building life science organizations. From March 2005 to June 2012, Ms.&#160;Schaeffer served as Senior Vice President, Administration and Human Resources, for Amicus Therapeutics
      where she was responsible for the human resources, facilities, and information technology functions. Prior to Amicus, she served as Senior Director, Human Resources, for three portfolio companies of Flagship Ventures (now Flagship Pioneering), a
      venture capital firm, and in that capacity she managed human resources for three life sciences companies. Ms.&#160;Schaeffer also held HR leadership positions with Oak Industries, from 1997 to 2000, and EMC Corporation, from 1994 to 1996. Ms.&#160;Schaeffer
      received her Bachelor of Arts degree from the University of Rochester and her Masters of Business Administration degree from Boston University.</font></p>
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      2018, bringing over 30&#160;years of experience in legal and compliance leadership roles. From August 2010 to November 2017, Mr.&#160;Soriano served as Senior Vice President and Chief Compliance Officer at Celgene Corporation, where he oversaw the Global
      Compliance Program. From November 2000 to February 2010, Mr.&#160;Soriano served as Vice President-Compliance and Deputy General Counsel at Ingersoll-Rand Company. Prior to that, Mr.&#160;Soriano worked as a litigation attorney at Becton Dickinson and&#160;Co.
      (December 1998 - November 2000), Johnson&#160;&amp; Johnson (February 1998 - December 1998), and Simpson Thacher&#160;&amp; Bartlett (September 1987 - February 1998). Mr.&#160;Soriano received his Bachelor of Arts degree from Princeton University&#8217;s Woodrow Wilson
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Corporate Governance Matters</b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Corporate Governance Materials and Practices.</i></b> Our written corporate
      governance materials, including our Bylaws, Corporate Governance Guidelines, Code of Business Conduct and Ethics, Audit Committee Charter, Compensation Committee Charter, Nominations and Governance Committee Charter, Science and Technology Committee
      Charter, and Director Resignation Policy are posted on our website at www.insmed.com under the heading &#8220;Investors&#8212;Corporate Governance.&#8221; None of the information in or that can be accessed through our website is incorporated by reference in this Proxy
      Statement. Our corporate governance practices include the following:</font></p>
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        <td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"></td>
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        <td style="font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board currently has a lead independent director, which our Corporate Governance Guidelines require in the event that
            the positions of Chair and CEO are combined, and all of our non-employee directors and Board committee members are independent.</font></td>
      </tr>

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        <td style="font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board has adopted a director resignation policy for uncontested director elections.</font></td>
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            nomination process. Our director composition reflects a mix of tenure on the Board (ranging from less than one year to 21&#160;years), which we believe provides an effective balance of historical perspective and an understanding of the evolution of
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      Conduct and Ethics that applies to all of our directors, officers (including our CEO, chief financial officer, controller and any person performing similar functions) and employees. Our Code of Business Conduct and Ethics contains written standards
      designed to communicate our expectations of our directors, officers, and employees when making decisions and conducting themselves in corporate activities, including the ethical handling and use of confidential information; actual or apparent
      conflicts of interest; compliance with applicable governmental laws, rules and regulations; protection of our assets and proprietary information; the ethical handling of payments and gifts received in the normal course of business and of payments
      made to government personnel; prompt internal reporting of violations of our Code of Business Conduct and Ethics; and accountability for adherence to our Code of Business Conduct and Ethics. We have established a means for individuals to report a
      violation or suspected violation of the Code of Business Conduct and Ethics anonymously, including those violations relating to accounting, internal controls or auditing matters, and federal securities laws. We intend to satisfy the disclosure
      requirements regarding any amendment to, or waiver from, a provision of the Code of Business Conduct and Ethics by making disclosures concerning such matters available on our website at www.insmed.com under the heading &#8220;Investors&#8212;Corporate
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      Guidelines to assist and guide the Board in the exercise of its responsibilities and establish a framework for our corporate governance practices. The Corporate Governance Guidelines contain written standards pertaining to director qualifications,
      director responsibilities, structure of our Board, director access to management and independent advisors, director compensation, and performance evaluation of our Board and committees, among other things. The Corporate Governance Guidelines help to
      ensure that the Board is independent from management, the Board adequately performs its oversight functions, and the interests of the Board and management align with the interests of our shareholders.</font></p>
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      the date of the certification of the election results, the Nominations and Governance Committee will make a recommendation to the Board as to whether to accept or reject the submitted resignation. Within 45&#160;days after receiving this recommendation,
      the Board must accept or reject the resignation or pursue another action unless doing so would cause us to fail to comply with federal or state law or Nasdaq listing standards. If more than a majority of the members of the Nominations and Governance
      Committee do not receive a greater number of votes cast &#8220;for&#8221; their election than votes &#8220;withheld,&#8221; the independent directors whose classes were not nominated for election will appoint a special committee to consider the resignations and make a
      recommendation to the Board. Any director whose resignation is under consideration will not participate in any deliberation or vote regarding his or her resignation. If the Board accepts a director&#8217;s resignation pursuant to this policy, the Board may
      decrease the size of the Board or fill the resulting vacancy in accordance with the Virginia Stock Corporation Act and our Articles of Incorporation and Bylaws.</font></p>
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      determination regarding the independence of each director annually, based on the recommendation of the Nominations and Governance Committee. The Board has determined that the following members of the Board are independent, as that term is defined
      under the general independence standards of the Nasdaq listing standards: Mr.&#160;Altomari, Mr.&#160;Brennan, Dr.&#160;Desjardins, Dr.&#160;Engelsen, Mr.&#160;McGirr, Ms.&#160;Anderson, Ms. Schafer, Dr.&#160;Sharoky and Mr.&#160;Lee. Mr.&#160;Lewis is not considered independent because he is
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      &#8220;Corporate Governance&#8212;Committees of the Board&#8212;Nominations and Governance Committee,&#8221; serves as an independent and objective party to identify, assess, recruit and recommend to the Board qualified candidates for directorship, consistent with criteria
      approved by the Board, and establishes and annually reviews such criteria based on factors it considers appropriate. The Board evaluates each nominee in the context of the Board as a whole, with the objective of recommending a group of nominees that
      can best oversee the business and affairs of the Company and use its diversity of experience to represent shareholder interests through the exercise of sound judgment. The Board seeks director nominees with experience in the pharmaceutical and
      biotechnology industries, as well as business, management, accounting and financial experience, among other areas. Among the factors that the Board and the Nominations and Governance Committee consider are strength of character, sound business
      judgment, career specialization, relevant technical skills, independence, the ability to commit sufficient time to the Board, and the extent to which the candidate would fill a present need on the Board, along with geographic, gender, age, racial and
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        Director Candidates.</i> The Nominations and Governance Committee evaluates all director candidates in accordance with the director qualification standards described above. The Nominations and Governance Committee evaluates a candidate&#8217;s
      qualifications to serve as a member of the Board based on the skills and characteristics of such individual Board member, as well as the composition of the Board as a whole. In addition, the Nominations and Governance Committee will evaluate a
      candidate&#8217;s independence, diversity, skills and experience in the context of the Board&#8217;s needs.</font></p>
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      Nominations and Governance Committee&#8217;s charter provides that the committee will consider director candidate recommendations by shareholders. Shareholders should submit any such recommendations for the Nominations and Governance Committee through the
      method described below under &#8220;Corporate Governance&#8212;Communications with the Board.&#8221; In accordance with our Bylaws, any person who is a shareholder of record on the record date for the shareholder meeting, on the date of the shareholder meeting, and on
      the date such person provides required notice to the Company may nominate persons for election to the Board if such shareholder complies with the notice procedures set forth in our Bylaws and summarized in this Proxy Statement under the heading
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      Board. Shareholders can send communications to the Board and, if applicable, to the Nominations and Governance Committee or to specified individual directors in writing c/o Ms.&#160;Christine Pellizzari, Corporate Secretary, Insmed Incorporated, 700 US
      Highway 202/206, Bridgewater, New Jersey, 08807. All communications sent to Ms.&#160;Pellizzari will be forwarded, as appropriate, to the Board, the Nominations and Governance Committee or any specified individual directors.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our policy is that directors are expected to make reasonable efforts to attend the
      annual meeting of shareholders absent unusual circumstances. All directors then on the Board attended the 2020 Annual Meeting of Shareholders.</font></p>
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      flexibility to make determinations about the separation of the positions of Board Chair and CEO. The Nominations and Governance Committee considers this structure as part of its annual review of the size, organization, structure, composition and
      operations of the Board and its committees. In November 2018, Mr. Lewis, our CEO, was appointed Chair of the Board and Mr.&#160;Brennan was elected as Lead Independent Director. The Board believes that its current leadership structure, with Mr.&#160;Lewis
      serving as CEO and Chair and Mr.&#160;Brennan serving as our Lead Independent Director, is appropriate for the Company at this time. Both Mr.&#160;Lewis and Mr.&#160;Brennan are actively engaged on significant matters affecting us, such as long-term strategy. The
      CEO has overall responsibility for all aspects of our operation, while the Lead Independent Director has a greater focus on governance of the Company, including oversight of the Board. We believe the combined role of CEO and Chair balanced with the
      shared leadership with the Lead Independent Director is a strength for the Company. As our Lead Independent Director, Mr.&#160;Brennan calls and chairs regular and special meetings of the Board and all executive sessions of the independent directors,
      chairs and presides at annual or special meetings of shareholders, provides meaningful input into the agenda of Board meetings, oversees the retention of outside advisors, consultants and legal counsel who report directly to the Board, consults
      frequently with committee chairs and management and has the right to and often does attend Board committee meetings.</font></p>
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      (Chair), Mr. Altomari, Dr.&#160;Engelsen, and Ms. Schafer, each of whom is an independent Board member. During 2020, the Audit Committee held six meetings.</font></p>
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      fulfilling its oversight responsibilities relating to the accounting, reporting and financial practices of the Company as well as overseeing our compliance with applicable legal and regulatory requirements. The Committee reviews and oversees:</font></p>
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      address such risk areas. The Audit Committee oversees disclosure controls and procedures, including applicable internal control over financial reporting and meets with the Chief Financial Officer, the Chief Legal Officer, the Chief Compliance
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      with the assistance of Willis Towers Watson, the Company&#8217;s independent compensation consultant, reviewed the executive compensation program and determined that the design of the compensation policies, including the components, weightings and focus of
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      Committee from retaining our independent registered public accounting firm in connection with a transaction initially recommended by such firm, the purpose of which may be tax deferral or reduction. The policy delegates pre-approval authority to the
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      consultations on matters addressed during the audit or quarterly reviews, review of documents filed with the SEC, and $115,000 and $125,000 paid to Ernst&#160;&amp; Young for consent and comfort letter procedures for registration statements filed in 2020
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      it deems appropriate, the purpose and potential benefits to us of the transaction, the related party&#8217;s interest in the transaction, the approximate dollar value involved in the transaction, whether the transaction was undertaken in the ordinary
      course of business, whether the related party transaction is on terms no less favorable to us than terms generally available to us from an unaffiliated third-party under the same or similar circumstances, and whether, under all the circumstances, the
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      regulations to furnish us with copies of all Section&#160;16(a) forms they file. As a matter of practice, members of our staff assist our executive officers and directors in preparing initial ownership reports and reporting ownership changes and typically
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      connection with the vesting of restricted stock units (RSUs). The transactions were not reported due to a clerical error. The names of the executives, date of the corrective Form 4s and number of shares of common stock withheld, respectively, are:
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        <td>&#160;</td>
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      </tr>
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        <td style="text-indent: -10pt; padding-left: 30pt">201 Bishopsgate EC2M&#160;3AE</td>
        <td>&#160;</td>
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        <td style="padding-right: 2pt; text-align: right">&#160;</td>
        <td style="text-align: left">&#160;</td>
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        <td>&#160;</td>
        <td style="text-align: left">&#160;</td>
        <td style="padding-right: 2pt; text-align: right">&#160;</td>
        <td style="text-align: left">&#160;</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
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      <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
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            10,372,426 shares of our Common Stock, with sole voting power over 2,151,339 of the shares and sole dispositive power over the 10,372,426 shares. For the purposes of the reporting requirements of the Exchange Act, Price Associates is deemed to
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            ownership of 9,363,127 shares of our Common Stock, with sole voting power over 0 shares, shared voting power over 234,946 shares, sole dispositive power over 9,046,541 shares and shared dispositive power over 316,586 shares. The subsidiaries
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a008"></a><b>PROPOSAL NO. 2</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>ADVISORY VOTE ON THE 2020 COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Information Regarding the Advisory Vote on the 2020 Compensation of our Named Executive Officers</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to Section&#160;14A of the Exchange Act, we are holding a shareholder advisory vote on the compensation of our named executive officers, as described in the
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RESOLVED, that the shareholders of Insmed Incorporated approve, on an advisory basis, the compensation of the Company&#8217;s named executive officers, disclosed pursuant to
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Compensation Committee oversees and administers our executive compensation program, including the evaluation and approval of compensation plans, policies and
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        <td>align management interests with the interests of our shareholders;</td>
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        <td>emphasize use of &#8220;at-risk&#8221; and performance-based compensation to motivate executives to advance our interests; and</td>
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        <td>provide executive compensation packages that are competitive in order to attract and retain executives whose skills are critical to the current and long-term success of the Company.</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Please read the &#8220;Compensation Discussion and Analysis&#8221; section starting on page 28 of this Proxy Statement for a detailed discussion about our executive compensation
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Vote Required for Approval of this Proposal</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The advisory vote on the compensation of our named executive officers will be approved by the affirmative vote of the majority of votes properly cast at the Annual
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">While this vote is being conducted on an advisory basis, and is therefore not binding on us, the vote will be carefully considered by the Compensation Committee and
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Recommendation</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>THE BOARD RECOMMENDS THAT YOU VOTE &#8220;FOR&#8221; THE APPROVAL, ON AN ADVISORY BASIS, OF THE 2020 COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a009"></a><b>COMPENSATION DISCUSSION AND ANALYSIS</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This Compensation Discussion and Analysis (the CD&amp;A) explains our compensation philosophy, policies and decisions for 2020 for the following executives, whom we
    refer to in this CD&amp;A and in the following tables as our named executive officers:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">1.</td>
        <td><b><i><u>William H. Lewis</u></i></b>, President and Chief Executive Officer, responsible for developing, in participation with the Board, our corporate mission and objectives and providing direction and leadership to ensure the execution of
          our corporate strategy and achievement of our objectives. Mr.&#160;Lewis was appointed as our Chair in November 2018.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">2.</td>
        <td><b><i><u>Sara Bonstein</u></i></b>, Chief Financial Officer, responsible for managing all financial activities, including internal and external reporting, financial planning and analysis, treasury, accounting, tax, and investor relations.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">3.</td>
        <td><b><i><u>Roger Adsett</u></i></b>, Chief Operating Officer, responsible for oversight of overall business operations, including global marketing, sales and commercial activities, business development, program management, technical operations
          and supply chain activities.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">4.</td>
        <td><b><i><u>Martina Flammer, M.D.</u>,</i></b> Chief Medical Officer, responsible for leading global clinical development, clinical operations, regulatory affairs, drug safety and pharmacovigilance, and medical affairs.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">5.</td>
        <td><b><i><u>Christine Pellizzari</u></i></b>, Chief Legal Officer, responsible for oversight of all corporate and litigation-related legal matters, government affairs and for providing ongoing legal support with respect to regulatory strategy,
          financing opportunities, business development initiatives, and intellectual property matters.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">6.</td>
        <td><b><i><u>John Goll</u></i></b>, Chief Accounting Officer, served as our principal financial officer from July 2019 to January 2020.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Executive Summary of Our 2020 Business and Strategic Achievements</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We are a global biopharmaceutical company on a mission to transform the lives of patients with serious and rare diseases. Our first commercial product, ARIKAYCE, is
    approved in the United States as ARIKAYCE (amikacin liposome inhalation suspension) and in Europe as ARIKAYCE&#174; Liposomal 590 mg Nebuliser Dispersion. ARIKAYCE received accelerated approval in the US in September 2018 for the treatment of Mycobacterium
    avium complex (MAC) lung disease as part of a combination antibacterial drug regimen for adult patients with limited or no alternative treatment options in a refractory setting. In October 2020, the European Commission (EC) approved ARIKAYCE for the
    treatment of nontuberculous mycobacterial (NTM) lung infections caused by MAC in adults with limited treatment options who do not have cystic fibrosis. In March 2021, Japan's Ministry of Health, Labour and Welfare (MHLW) approved ARIKAYCE (amikacin
    liposome inhalation suspension) for the treatment of patients with NTM lung disease caused by MAC who did not sufficiently respond to prior treatment with a multidrug regimen. NTM lung disease caused by MAC (which we refer to as MAC lung disease) is a
    rare and often chronic infection that can cause irreversible lung damage and can be fatal.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our clinical-stage pipeline includes brensocatib and treprostinil palmitil inhalation powder (TPIP). Brensocatib is a novel oral, reversible inhibitor of dipeptidyl
    peptidase 1, which we are developing for the treatment of patients with bronchiectasis and other neutrophil-mediated diseases. TPIP is an inhaled formulation of the treprostinil prodrug treprostinil palmitil which may offer a differentiated product
    profile for pulmonary arterial hypertension (PAH) and other rare pulmonary disorders.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In 2020, our named executive officers played critical roles in the furtherance of our mission. We continued to focus on the execution and successful US
    commercialization of ARIKAYCE and potential label expansion. In October 2020, the US Food and Drug Administration (FDA) approved a supplemental new drug application for ARIKAYCE, adding important efficacy data regarding the durability and
    sustainability of culture conversion to the ARIKAYCE label. In December 2020, we commenced the post-approval confirmatory front-line clinical trial program for ARIKAYCE in patients with MAC lung disease. The front-line clinical trial program consists
    of the ARISE trial, an interventional study designed to validate cross-sectional and longitudinal characteristics of patient-reported outcome (PRO) tool in MAC lung disease, and the ENCORE trial, designed to establish the clinical benefits and evaluate
    the safety of ARIKAYCE in patients with newly diagnosed MAC using the PRO tools validated in the ARISE trial.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In 2020, the Company also continued its efforts to advance ARIKAYCE globally. In March 2020, we submitted a new drug application (JNDA) to Japan's Ministry of Health,
    Labour and Welfare (MHLW) for the treatment of patients with MAC lung disease who did not sufficiently respond to prior treatment. In June 2020, a Japanese Medical Device Notification (JMDN) was submitted to the MHLW for Lamira, the designated device
    for administration of ARIKAYCE. The JMDN was accepted and Lamira is authorized for use in Japan. In addition, in October 2020, the EC approved ARIKAYCE for the treatment of NTM lung infections caused by MAC in adults with limited treatment options who
    do not have cystic fibrosis. In the fourth quarter of 2020, we launched ARIKAYCE in Germany. In February 2021, we launched ARIKAYCE in the Netherlands.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We also have a robust pipeline which includes the following product candidates:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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      <tr style="vertical-align: bottom">
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        <td style="border-bottom: Black 1pt solid; width: 18%; text-align: center; padding-bottom: 2pt"><font style="font-size: 8pt"><b>Product Candidate</b></font></td>
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        <td style="border-bottom: Black 1pt solid; width: 62%; text-align: center; padding-bottom: 2pt"><font style="font-size: 8pt"><b>Potential Rare Disease Area(s)</b></font></td>
      </tr>
      <tr style="vertical-align: top">
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        <td style="padding-top: 2pt; border-bottom: Black 1pt solid; padding-bottom: 2pt">Brensocatib</td>
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        <td style="padding-top: 2pt; border-bottom: Black 1pt solid; padding-bottom: 2pt">Therapeutic potential in bronchiectasis and other neutrophil-mediated diseases</td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-top: 2pt; border-bottom: Black 1pt solid; padding-left: 10pt; text-indent: -10pt; padding-bottom: 2pt"><b>Clinical Stage</b></td>
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        <td style="padding-top: 2pt; border-bottom: Black 1pt solid; padding-bottom: 2pt">Formulation that may offer a differentiated product profile for patients with PAH and other rare pulmonary disorders</td>
      </tr>
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        <td style="padding-top: 2pt; padding-left: 10pt; text-indent: -10pt; padding-bottom: 2pt"><b>Early Stage</b></td>
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        <td style="padding-top: 2pt; padding-bottom: 2pt">Various pre-clinical compounds</td>
        <td style="padding-top: 2pt; padding-bottom: 2pt">&#160;</td>
        <td style="padding-top: 2pt; padding-bottom: 2pt">Opportunities related to multiple rare diseases of unmet medical need, <font style="background-color: white">including NTM lung disease </font></td>
      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In June 2020, we announced full results from our Phase 2 WILLOW study evaluating the efficacy, safety, and pharmacokinetics of brensocatib administered once daily in
    adults with non-cystic fibrosis bronchiectasis (NCFBE). Final results from the WILLOW study were published online in the New England Journal of Medicine in September 2020. In June 2020, the FDA granted breakthrough therapy designation for brensocatib
    for the treatment of adult patients with bronchiectasis for reducing exacerbations. In December 2020, we commenced a Phase 3 trial (the ASPEN trial) through which we will seek to confirm the positive results seen in the WILLOW study.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In September 2020, we initiated dosing of the first subjects in a Phase 1 healthy volunteer trial of TPIP in the US to assess the pharmacokinetics and tolerability
    profile of TPIP. In February 2021, we announced topline results from the Phase 1 study of TPIP in healthy volunteers. Data from the study demonstrated that TPIP was generally well tolerated, with a pharmacokinetic profile that supports continued
    development with once-daily dosing.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">These strategic advancements were made despite the operational challenges presented by COVID-19. Our named executive officers moved swiftly to implement business
    continuity plans that prioritized the health and safety of our employees while ensuring we could continue to progress our work and support our customers and patients. Where possible, employees were provided the ability to work virtually. Our workplaces
    and laboratory facilities were evaluated and maintained for social distancing and sanitation on a daily basis in line with state and the guidelines of the Centers for Disease Control and Prevention.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">To complement our internal research and development, we actively evaluate in licensing and acquisition opportunities for a broad range of rare diseases.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">More broadly from a strategic and operational standpoint, in 2020 we expanded our leadership team with talented executives in key financial, medical, commercial,
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Compensation Philosophy and Principles</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We operate in a competitive, rapidly changing and heavily-regulated industry. The long-term success of our business requires us to be resourceful, adaptable, and
    innovative, and the skills, talent, and dedication of our executive officers are critical components to this success. Therefore, our compensation program for our executive officers, including our named executive officers, is designed to attract,
    retain, and incentivize the best possible talent. The Company&#8217;s compensation program for named executive officers is structured to implement the following guiding principles:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Alignment with Shareholder Interests.</i></b></font> A significant portion of our named
    executive officers&#8217; compensation is in the form of equity awards based on our belief that equity awards align management&#8217;s interests with the creation of future shareholder value.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Use of &#8220;At-Risk&#8221; Compensation to Incentivize Executives.</i></b></font> A substantial
    portion of our named executive officers&#8217; compensation is based on &#8220;at risk,&#8221; or variable, compensation, such as annual cash incentives and stock options. We believe this mix of compensation best aligns the interests of our named executive officers with
    those of our shareholders over time and contributes to the achievement of short-term goals and the advancement of our long-term strategy through long-term goals. In 2020, approximately 89% of our CEO&#8217;s compensation was &#8220;at risk,&#8221; and 82% of our other
    named executive officers&#8217; compensation was &#8220;at risk&#8221;. The charts below reflecting compensation to our non-CEO named executive officers do not include compensation paid to Mr.&#160;Goll, who served as our principal financial officer until January 31, 2020.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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      </tr>
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  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
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      <tr style="vertical-align: bottom">
        <td style="width: 50%; padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2020 Other NEO Compensation</b></font></td>
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      </tr>
      <tr style="vertical-align: bottom">
        <td style="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt">&#160;</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Pay for Performance.</i></b></font> We reward the named executive officers for
    attaining established Company and individual goals. The attainment of these goals requires the named executive officer to dedicate his or her time, effort, skills and business experience to the long-term success of the Company and the maximization of
    shareholder value. A significant portion of the named executive officers&#8217; compensation is based on Company and individual performance, and the compensation program is designed to reward both short-term and long-term performance. Short-term performance
    of our named executive officers is principally rewarded through annual cash incentives that reflect the achievement of corporate goals and, with respect to named executive officers other than our President and CEO, individual goals. Long-term
    performance of our named executive officers is largely rewarded through stock option and RSU awards that are eligible to vest based on continued service and have a value tied to share price appreciation.</p>
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    compensation program is designed to allow the Company to attract and retain individuals whose skills are critical to the current and long-term success of the Company. Because competition for top talent is intense in our industry, retention is a key
    objective of the compensation program. The compensation program is designed to appropriately compensate our executive officers for the success of the Company from a competitive standpoint, so that they remain with the Company and continue to contribute
    to the Company&#8217;s long-term success. We seek to achieve this objective by granting equity in a combination of stock options and RSU awards that vest based on continued service.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">At our 2020 Annual Meeting of Shareholders, we held an advisory vote on the compensation of our named executive officers. Over 97% of the shares voted were voted in
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Corporate Governance Perspectives on our Executive Compensation Program</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We believe the following aspects of our executive compensation program reflect our commitment to strong corporate governance:</p>
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        <td>Our Compensation Committee has overall responsibility for executive compensation plans, policies and programs, although our independent Board members approve recommendations made by our Compensation Committee regarding the compensation of our
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>Performance metrics that govern incentive compensation are established by our Compensation Committee at the start of each fiscal year and are reviewed by our Compensation Committee at the end of the year;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>Our executive compensation program, in the aggregate, rewards performance and aims to drive the Company&#8217;s strategic objectives;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>Payouts made pursuant to individual and corporate multiplier ranges are capped at a predetermined maximum amount, irrespective of performance that exceeds objectives;</td>
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        <td>Our Compensation Committee has the ability to exercise its discretion to reduce or eliminate incentive compensation payouts;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>We have share ownership guidelines in place for our President and CEO, pursuant to which he must hold shares of Common Stock, vested in-the-money stock options and unvested RSUs having an aggregate value equal to at least three times his base
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        <td>We also have share ownership guidelines in place for certain of our other senior executives, pursuant to which they must hold shares of Common Stock, vested in-the-money stock options and unvested RSUs having an aggregate value equal to his or
          her base salary within five&#160;years of the adoption of the guidelines or date of hire, whichever is later. As of the Record Date, Mr.&#160;Adsett, Ms.&#160;Pellizzari and Dr. Flammer satisfied these guidelines. Mr.&#160;Goll is not subject to our share ownership
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
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        <td>Our Compensation Committee regularly meets in executive session without members of management present;</td>
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        <td>Our independent compensation consultant reports directly to the Compensation Committee and meets regularly with the Compensation Committee without management present;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>The employment agreements for our named executive officers do not provide for tax &#8220;gross-ups&#8221; or severance payments on a change in control absent termination of the named executive officer&#8217;s employment;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>Our executive compensation program seeks to balance short-term pay opportunities through annual cash incentives with long-term incentive opportunities through equity awards and employs both fixed compensation components (base salary) and
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      </tr>

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        <td>Our insider trading policy prohibits our employees, including officers, and directors from (i)&#160;engaging in hedging transactions (whether through the use of financial instruments such as prepaid variable forwards, equity swaps, collars, exchange
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, the Compensation Committee annually reviews a compensation risk assessment conducted by management. The Compensation Committee does not believe that our
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Executive Compensation Determination Process</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Role of the Compensation Committee and the Board in Making Compensation Decisions.</i></b></font>
    Our Compensation Committee has been delegated the authority to make determinations regarding all elements of compensation for our executive officers, except for Mr.&#160;Lewis, our President and CEO. Our Compensation Committee recommends to our independent
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Role of Management.</i></b></font> The Compensation Committee, in making executive
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    compensation and performance of our named executive officers (aside from his own compensation and performance) and Company performance. The Compensation Committee considered the President and CEO&#8217;s assessment along with the input of its independent
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Role of the Compensation Consultant. </i></b></font>The Compensation Committee is
    authorized to select and retain its own independent compensation consultant and has routinely sought the advice of an independent compensation consultant regarding our executive compensation practices. During 2020, Willis Towers Watson provided a
    comprehensive review of long term incentive guidelines for all employee levels, an unvested equity analysis to assess the retention power of our compensation program for senior executives, and data and recommendations on executive officer compensation.
    The Compensation Committee evaluates the independence of its compensation consultant on an annual basis and has concluded that Willis Towers Watson was independent during its tenure in 2020.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Compensation Evaluation Processes and Criteria.</i></b></font> Given the high demand
    for the experienced and well-qualified executives we seek to employ, the Compensation Committee reviews data and information from a variety of sources such as outside surveys of compensation and benefits for executive officers in the biotechnology
    industry, as well as public information regarding executive compensation at peer biotechnology companies. The Compensation Committee also draws upon the personal knowledge of its members with respect to executive compensation at comparable companies.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In determining the amount and composition of compensation elements (cash and non-cash elements and short- and long-term elements) for our non-CEO named executive
    officers, our Compensation Committee reviews the performance of each executive officer holistically. In setting compensation levels for our executive officers for 2020, our Compensation Committee considered many factors, including, but not limited to,
    the following factors:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <td>our achievement of certain product development, financial, strategic planning and other goals;</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>each non-CEO named executive officer&#8217;s individual performance against pre-established goals, as discussed in more detail below;</td>
      </tr>

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        <td>the scope and strategic impact of each executive officer&#8217;s responsibilities;</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>our past business performance;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td>our long-term goals and strategies;</td>
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        <td>the experience of each executive officer;</td>
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        <td>past compensation levels of each executive officer and of the executives as a group;</td>
      </tr>

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  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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        <td>relative levels of pay among executive officers;</td>
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        <td>the amount of each element of compensation in the context of the executive officer&#8217;s total compensation and other benefits;</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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        <td>for each executive officer other than the President and CEO, the evaluations and recommendations of our President and CEO; and</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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        <td>the competitiveness of our compensation relative to selected peer group companies and other survey data, which are described below.</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Consideration of these factors is subjective. No relative weights or rankings are assigned to them except as otherwise discussed in this CD&amp;A.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">For the President and CEO&#8217;s compensation, the Compensation Committee reviews and evaluates the performance of the President and CEO and recommends to the Board the
    individual elements of his total compensation, considering, among other things, individual performance, experience, prior compensation levels, and our general performance objectives, as well as the compensation practices of peer companies and the
    markets in which we compete for executive talent. The Board then must approve the President and CEO&#8217;s compensation. The President and CEO may not be present during voting or deliberations on his compensation.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Selection of Peer Companies and Benchmarking</i></b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Compensation Committee, with the support of its independent compensation consultant, conducts an annual review of the peer group used for benchmarking compensation
    levels. In assessing potential peers, consideration is given to publicly traded biopharmaceutical companies that are similar to the Company in terms of the number of employees, market capitalization and stage of product development. The only change to
    the peer group for 2020 was the removal of Loxo Oncology, Inc. following its acquisition by Eli Lilly.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The number of employees at the companies in our 2020 peer group ranged from 136 to 893, with a median of 367 employees, and these companies had market capitalizations
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    2019, other than for Array BioPharma, Inc. which had been acquired by that point but retained in our peer group given its most recently filed Proxy Statement was still available. The peer group was identified assuming an estimated 373 Company employees
    and an estimated market capitalization for the Company of approximately $1.53&#160;billion. The table below depicts our 2020 peer group:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Corcept Therapeutics Incorporated</font></td>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Immunomedics, Inc.</font></td>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Spark Therapeutics,&#160;Inc.</font></td>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Intercept Pharmaceuticals,&#160;Inc.</font></td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Compensation Committee concluded that this adjustment to the peer group was appropriate given the number of employees, market capitalization, stage of development
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Components of Compensation</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In summary, the compensation paid to our executive officers in 2020 included the following components:</p>
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        <td style="border-bottom: Black 1pt solid; padding: 2pt 10pt; text-indent: -10pt">Base Salary</td>
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        <td style="border-bottom: Black 1pt solid; padding-top: 2pt; padding-bottom: 2pt">Provide market competitive benefits to protect employees&#8217; and their covered dependents&#8217; health and welfare. Provide a program to foster retirement savings.</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The components of our compensation program and compensation decisions for 2020 for each named executive officer are described in more detail below:</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Compensation Committee reviews and sets base salaries for executives, other than the President and CEO, on an annual basis during the first quarter of each year.
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our named executive officers received merit-based increases to their base salaries in January 2020, as shown in the table below.</p>
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    important to incentivize our non CEO named executive officers, and reflect their actual individual performance. Given Mr. Lewis&#8217;s substantial influence on the overall performance of the Company, the Compensation Committee believed it was appropriate
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2018</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$610,000</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
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        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$1,174,995</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$3,524,964</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$622,200</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$11,000</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$5,943,159</font></td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: White">
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        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$386,615</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$75,000</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$2,024,075</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$224,700</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$11,400</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$2,721,790</font></td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2019</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: White">
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-left: 20pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2018</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$514,300</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
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        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$624,981</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$1,875,065</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$264,900</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$14,700</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$3,293,946</font></td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: White">
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        <td>&#160;</td>
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        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$475,741</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
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        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$1,124,990</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$1,874,999</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$237,900</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$14,773</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$3,728,403</font></td>
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      <tr style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$458,280</font></td>
        <td>&#160;</td>
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        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$474,993</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$1,425,015</font></td>
        <td>&#160;</td>
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        <td>&#160;</td>
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        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$20,833</font></td>
        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
        <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8212;</font></td>
        <td>&#160;</td>
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    the year of termination, his equity award vesting would be limited to accelerated vesting of all time based equity awards that would otherwise have vested within six months following his termination date, and he would be entitled to receive a
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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          <td style="width: 33%">&#160;</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">For purposes of the employment agreements, the term &#8220;cause&#8221; generally includes:<br style="clear: both">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
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      </tr>

  </table>
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  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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      </tr>

  </table>
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  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
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      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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      </tr>

  </table>
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  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">(a)</td>
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      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">(b)</td>
        <td>a material diminution in the executive&#8217;s authority, duties, or responsibilities;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
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      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
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      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
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        <td style="width: 0.5in">3.</td>
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      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <table style="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: bottom">
        <td style="padding-bottom: 1pt"><font style="font-size: 8pt">&#160;</font></td>
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        <td style="padding-bottom: 1pt; font-weight: bold"><font style="font-size: 8pt">&#160;</font></td>
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      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
        <td style="width: 35%; text-align: left; text-indent: -10pt; padding-left: 10pt">William H. Lewis</td>
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        <td style="width: 12%; text-align: right">$2,111,105</td>
        <td style="width: 1%">&#160;</td>
        <td style="width: 12%; text-align: right">$395,832</td>
        <td style="width: 1%">&#160;</td>
        <td style="width: 12%; text-align: right">$45,220</td>
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        <td style="text-align: right">$882,000</td>
        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="text-align: right">$703,838</td>
        <td>&#160;</td>
        <td style="text-align: right">$1,788,294</td>
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      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
        <td style="text-align: right">$1,080,030</td>
        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="text-align: right">$34,456</td>
        <td>&#160;</td>
        <td style="text-align: right">$7,093,426</td>
        <td>&#160;</td>
        <td style="text-align: right">$8,413,632</td>
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        <td>&#160;</td>
        <td style="text-align: right">$1,050,000</td>
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        <td>&#160;</td>
        <td style="text-align: right">$22,715</td>
        <td>&#160;</td>
        <td style="text-align: right">$2,343,645</td>
        <td>&#160;</td>
        <td style="text-align: right">$3,616,360</td>
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        <td style="text-align: right">$999,915</td>
        <td>&#160;</td>
        <td style="text-align: right">$190,460</td>
        <td>&#160;</td>
        <td style="text-align: right">$45,220</td>
        <td>&#160;</td>
        <td style="text-align: right">$5,295,442</td>
        <td>&#160;</td>
        <td style="text-align: right">$6,531,037</td>
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        <td style="text-align: right">$345,050</td>
        <td>&#160;</td>
        <td style="text-align: right">$120,768</td>
        <td>&#160;</td>
        <td style="text-align: right">$30,147</td>
        <td>&#160;</td>
        <td style="text-align: right">$1,000,278</td>
        <td>&#160;</td>
        <td style="text-align: right">$1,496,243</td>
      </tr>
      <tr style="vertical-align: bottom">
        <td style="text-align: left; text-indent: -10pt; padding-left: 10pt">&#160;</td>
        <td>&#160;</td>
        <td style="text-align: right">&#160;</td>
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        <td>&#160;</td>
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  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="padding-top: 3pt; border-top: Black 1pt solid; width: 0"></td>
        <td style="padding-top: 3pt; border-top: Black 1pt solid; width: 0.5in">(1)</td>
        <td style="padding-top: 3pt; border-top: Black 1pt solid">These payments would be payable to the executive upon a qualified termination under the applicable agreement. The cash severance figure for Mr.&#160;Lewis includes salary for two years plus two
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      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0"></td>
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        <td>The value used in the table assumes the full target bonus for the year.</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top; text-align: justify">
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        <td style="width: 0.5in">(3)</td>
        <td>The value represents the acceleration of all applicable equity awards outstanding as of December 31, 2020. The value realized upon the accelerated vesting of (i) stock options is calculated by multiplying the number of stock options subject to
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table summarizes the hypothetical payments that could have been made by us with respect to each of the named executive officers below assuming that a
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: bottom">
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        <td style="border-bottom: Black 1pt solid; font-size: 8pt; font-weight: bold; text-align: center">Benefits</td>
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      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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      </tr>
      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
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        <td>&#160;</td>
        <td style="text-align: right">$190,460</td>
        <td>&#160;</td>
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        <td>&#160;</td>
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        <td>&#160;</td>
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      <tr style="vertical-align: bottom; background-color: White">
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        <td style="text-align: right">$172,525</td>
        <td>&#160;</td>
        <td style="text-align: right">$120,768</td>
        <td>&#160;</td>
        <td style="text-align: right">$15,074</td>
        <td>&#160;</td>
        <td style="text-align: right">$320,383</td>
        <td>&#160;</td>
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      </tr>
      <tr style="vertical-align: bottom">
        <td style="border-bottom: Black 1pt solid; text-align: left; text-indent: -10pt; padding-left: 10pt">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">&#160;</td>
      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="padding-top: 3pt; width: 0"></td>
        <td style="padding-top: 3pt; width: 0.5in">(1)</td>
        <td style="padding-top: 3pt">These payments and other benefits would be payable to the executive upon a qualified termination under the applicable agreement. The cash severance figure for Mr.&#160;Lewis consists of one and one-half times his base salary
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      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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        <td>The value used in the table assumes the full target bonus for the year.</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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        <td>For Mr.&#160;Lewis, the value represents the acceleration of all time-based vesting equity outstanding as of December&#160;31, 2020 granted at least one year prior to the termination date. For Ms. Bonstein, Mr.&#160;Adsett, Dr. Flammer, Ms. Pellizzari and Mr.
          Goll, the value represents accelerated vesting of all time-based equity that would have otherwise vested within 12&#160;months following the termination date. The value realized upon the accelerated vesting of (i)&#160;stock options is calculated by
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      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a011"></a><b>COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Compensation Committee is comprised entirely of independent directors, and none of our executive officers served on the Compensation Committee or on the board of
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a012"></a>DODD-FRANK MANDATED CEO PAY RATIO</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As required by Section&#160;953(b) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item&#160;402(u) of Regulation&#160;S-K, we are providing the following
    information about the relationship of the median annual total compensation of our employees and the annual total compensation of Mr.&#160;Lewis, our President and CEO. Registrants may identify the median employee once every three years unless there has been
    a change in their employee population or employee compensation arrangements that the registrant reasonably believes would result in a significant change in pay ratio disclosure. The pay ratio included in this section is calculated in a manner
    consistent with Item&#160;402(u) of Regulation&#160;S-K.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

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        <td>In 2020, we determined the median of the annual total compensation of all employees of our company (other than Mr.&#160;Lewis) for 2020 was $299,008.</td>
      </tr>

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        <td>For 2020, the annual total compensation of Mr.&#160;Lewis, as reported in the Summary Compensation Table, is $6,185,704.</td>
      </tr>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Based on this information, the ratio of the median of the annual total compensation of all employees (other than Mr.&#160;Lewis) to the annual total compensation of
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">To identify the median of the annual total compensation of all of our employees (other than Mr. Lewis), as well as to determine the annual total compensation of our
    median employee, we took the following steps:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">1.</td>
        <td>We determined that, as of December&#160;31, 2020, our employee population, excluding Mr.&#160;Lewis, consisted of approximately 523 individuals working either at Insmed Incorporated or one of our consolidated subsidiaries. This population consisted of
          our full-time, part-time and temporary employees and, as permitted by SEC rules, excluded independent contractors or similar non-employee workers during 2020. We did not exclude any non-US employees from these calculations.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">2.</td>
        <td>To identify the &#8220;median employee&#8221; from our employee population, we compared the sum of each employee&#8217;s wages, aggregate fair value of equity awards and target cash bonus for 2020. In doing so, we annualized the salary of all permanent employees
          who were hired in 2020 but did not work for us the entire fiscal year. The fair value of option awards granted during 2020 was calculated using the Black-Scholes valuation model pursuant to the assumptions described in Note&#160;10, &#8220;Stock-Based
          Compensation&#8221; of the consolidated financial statements included in our Annual Report on Form&#160;10-K for the fiscal year ended December&#160;31, 2020. We did not make any cost-of-living adjustments in identifying the median employee.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">3.</td>
        <td>After identifying the median employee, we calculated annual total compensation for the employee using the same methodology we use for our named executive officers, as set forth in the Summary Compensation Table. This process resulted in a
          median employee with annual total compensation of $299,008 for 2020.</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The SEC&#8217;s rules for identifying the median employee and calculating the pay ratio based on that employee&#8217;s annual total compensation allow companies to adopt a variety
    of methodologies, to apply certain exclusions, and to make reasonable estimates and assumptions that reflect their employee populations and compensation practices. As a result, the pay ratios reported by other companies may not be comparable to our pay
    ratio, reported above, as other companies have different employee populations and compensation practices and may utilize different methodologies, exclusions, estimates and assumptions in calculating their own pay ratios.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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    <table style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" cellpadding="0" cellspacing="0">

        <tr style="vertical-align: top; text-align: left">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a013"></a><b>DIRECTOR COMPENSATION</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Board determines the compensation of our non-employee directors based in part on recommendations made by the Compensation Committee. The Compensation Committee
    evaluates the form and amount of compensation for non-employee directors at least annually and recommends changes to our Board when appropriate. Our Board is currently compensated through a combination of cash retainers and equity awards in the form of
    RSUs. Our approach to Board compensation is intended to align our non-employee director compensation practices with the interests of our shareholders. For example, we have share ownership guidelines in place for our non-employee directors, with a
    target share ownership of three times the amount of each director&#8217;s annual retainer that should be achieved within five years after the adoption of the guidelines or first appointment to the Board, whichever is later. As of the Record Date, all of our
    non-employee directors who had been on the Board for at least five years exceeded the share ownership guidelines. Mr.&#160;Lewis is a director and an executive officer of the Company. He receives no additional compensation for serving on the Board. Our
    share ownership guidelines for Mr.&#160;Lewis are described under &#8220;Compensation Discussion and Analysis&#8212;Corporate Governance Perspectives on our Executive Compensation Program&#8221; above. No other director is an employee of the Company.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Fees Earned or Paid in Cash</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our non-employee directors are paid quarterly retainer fees for their service on the Board. Our non-employee directors are not compensated for attending individual
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    Nominations and Governance Committee was paid an additional annual fee of $10,000; the Chair of the Compensation Committee was paid an additional annual fee of $15,000; the Chair of the Audit Committee was paid an additional annual fee of $20,000; and
    the Chair of the Science and Technology Committee was paid an additional annual fee of $15,000. Annual retainer fees for non-chair committee members were paid as follows: members of the Nominations and Governance Committee, $5,000; members of the
    Compensation Committee, $7,500; members of the Audit Committee, $10,000; and members of the Science and Technology Committee, $7,500. Ms. Schafer&#8217;s compensation was prorated to reflect her appointment as of April 1, 2020.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Grant of Restricted Stock Units</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On May 14, 2020, each non-employee director received an annual equity-based grant with a grant date fair value of approximately $200,000 in the form of RSUs. The RSUs
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition, on April 1, 2020, Ms. Schafer received an equity-based grant with a grant date
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We reimburse all of our directors for expenses incurred in connection with their attendance at Board or committee meetings. We also provide director and officer
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table sets forth a summary of the compensation we paid to our non-employee directors in 2020.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">To improve readability, only the columns &#8220;Fees Earned or Paid in Cash,&#8221; &#8220;Stock Awards,&#8221; and &#8220;Total&#8221; have been included in the table. All other columns have been
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif" cellpadding="0" cellspacing="0">

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        <td style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><font style="font-size: 8pt">Fees Earned<br>
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        <td>&#160;</td>
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        <td>&#160;</td>
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      </tr>
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        <td>&#160;</td>
        <td style="text-align: right">$200,000</td>
        <td>&#160;</td>
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        <td>&#160;</td>
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      </tr>
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        <td>&#160;</td>
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        <td>&#160;</td>
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      </tr>
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        <td>&#160;</td>
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      </tr>

  </table>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-top: 2pt; width: 0.5in">(1)</td>
        <td style="padding-top: 2pt">Amounts in this column reflect grant date fair values of stock awards granted during 2020, calculated in accordance with FASB ASC Topic 718, except the assumption of forfeitures is not made.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
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        <td>Each of our non-employee directors received a grant of 8,097 RSUs in May 2020. As of December&#160;31, 2020, each of our non-employee directors held 8,097 RSUs, with the exception of Ms. Schafer, who held 9,702 RSUs.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
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        <td>No option awards were granted to our directors in 2020. None of our other non-employee directors held options as of December&#160;31, 2020.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
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        <td>Ms. Schafer&#8217;s compensation was prorated to reflect her appointment as of April 1, 2020. Ms. Schafer received a pro-rated non-employee director grant of 1,605 RSUs upon her appointment to the board.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a014"></a><b>PROPOSAL NO. 3</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>RATIFICATION OF THE APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Information Relative to Ratification of the Appointment of Independent Registered Public Accounting Firm</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Audit Committee has appointed Ernst&#160;&amp; Young as our independent registered public accounting firm for the year ending December&#160;31, 2021. Shareholder
    ratification of the appointment of our independent registered public accounting firm is not required under Virginia law, our Articles of Incorporation or our Bylaws. However, the Board is submitting the appointment of Ernst&#160;&amp; Young to our
    shareholders for ratification as a matter of good corporate governance. A representative of Ernst&#160;&amp; Young is expected to attend the Annual Meeting and will have an opportunity to make a statement and respond to appropriate questions.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The principal function of Ernst&#160;&amp; Young is to audit our consolidated financial statements and attest on the effectiveness of our internal control over financial
    reporting and, in connection with these audits, to review certain related filings submitted to the SEC and to conduct limited reviews of the consolidated financial statements included in each of our quarterly reports. The aggregate fees billed for each
    of the last two years for professional services rendered by Ernst&#160;&amp; Young, as well as information relating to the Audit Committee&#8217;s pre-approval policies and procedures, are detailed under &#8220;Audit Committee Report and Independent Auditor Fees.&#8221;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Vote Required for Approval of this Proposal</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Ratification of the appointment of Ernst&#160;&amp; Young as the Company&#8217;s independent registered public accounting firm for the year ending December&#160;31, 2021 requires the
    affirmative vote of a majority of the votes properly cast at the Annual Meeting. Abstentions are not considered votes cast and, therefore, will have no effect on the voting outcome. If your shares are held in street name, your broker or agent has
    discretionary authority to vote shares held through it in the absence of your instruction regarding how your shares should be voted.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In the event that this proposal is not approved, the Audit Committee plans to consider the vote and the reasons therefore in future decisions on the selection of our
    independent registered public accounting firm. Even if the appointment is ratified, the Audit Committee may engage different independent auditors at any time during the year if it determines that such a change would be in our best interests and those
    of our shareholders.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Recommendation</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>THE BOARD RECOMMENDS THAT YOU VOTE &#8220;FOR&#8221; THE RATIFICATION OF THE APPOINTMENT OF ERNST&#160;&amp; YOUNG AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE YEAR
      ENDING DECEMBER 31, 2021.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>&#160;</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a015"></a><b>PROPOSAL NO. 4</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>AMENDMENT NO. 2 TO THE INSMED INCORPORATED 2019 INCENTIVE PLAN</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The 2019 Incentive Plan was approved by our shareholders at the 2019 Annual Meeting of Shareholders. Amendment No. 1, which provided for the issuance of 4,500,000
    additional shares of Common Stock under the 2019 Incentive Plan, was approved by our shareholders at the 2020 Annual Meeting of Shareholders. The 2019 Incentive Plan was further amended by the Omnibus Amendment to Insmed Incorporated Incentive Plans,
    dated December 10, 2020, to permit the transfer of certain awards for estate-planning purposes. The Board of Directors adopted on March&#160;30, 2021, subject to shareholder approval, Amendment No.&#160;2 to the 2019 Incentive Plan (the Amendment) to provide for
    the issuance of 2,750,000 additional shares of Common Stock under the 2019 Incentive Plan. No other changes to the 2019 Incentive Plan are proposed or recommended. The Amendment is attached hereto as Appendix&#160;A.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Background and Purpose</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If the Amendment is not approved, we will have remaining only 3,768,849 shares available for future grant under the 2019 Incentive Plan (plus any shares that might be
    returned to the 2019 Incentive Plan as a result of future cancellations, terminations, expirations, forfeitures and lapses), based on awards outstanding as of the Record Date, and thereafter we will have limited ability to grant additional equity
    incentives under the 2019 Incentive Plan. Among other activities, we continue to focus on the successful commercialization of ARIKAYCE in the US and Europe for appropriate patients, are seeking regulatory approvals for ARIKAYCE in Japan, continue to
    advance the post-approval confirmatory, frontline clinical trial program for ARIKAYCE, through the ARISE trial and the ENCORE trial, and continue to advance the ASPEN trial of brensocatib, to seek to confirm the positive results seen in the WILLOW
    trial and to support a new drug application. We expect these activities to result in continued increases in our employee headcount. To ensure that we have sufficient equity plan capacity to compensate and incentivize our employees as we undertake these
    activities, the Board adopted the Amendment and strongly recommends that our shareholders approve the Amendment.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Equity based compensation is a vital part of our compensation program for our employees, including our named executive officers, and our non employee directors. We
    believe equity based compensation creates an ownership culture that rewards our executives for maximizing shareholder value over time and aligns the interests of our employees and directors with those of our shareholders. We have traditionally granted
    stock options to new hires in connection with their commencement of employment and stock options, as well as other forms of equity based compensation, to key employees as part of their ongoing compensation packages. In 2018, we began granting RSUs to
    our employees. We believe that providing these equity awards incentivizes employees, including management, to create long term shareholder value and aids in retention efforts, as awards generally vest over a number of years. In addition, we grant RSUs
    to non employee directors annually as part of their compensation for service on the Board.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board currently intends that the 2,750,000 shares requested under the Amendment, in
      addition to the 3,768,849</font> <font style="font-size: 8pt">s</font>hares available for future grant under the 2019 Incentive Plan (plus any shares that might be returned to the 2019 Incentive Plan as a result of future cancellations,
    terminations, expirations, forfeitures and lapses), will be sufficient to fund the Company&#8217;s annual stock option and RSU grants to current employees as well as equity grants to new hires for at least the next year, which it believes appropriate taking
    into account the Company&#8217;s planned growth. Upon a review of the remaining shares available for grant under our 2019 Incentive Plan and the anticipated need for future equity award issuances, the Board approved the Amendment and the share pool
    authorized for issuance thereunder to ensure that we have sufficient equity plan capacity to continue to provide our eligible employees and directors with appropriate equity-based incentives.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Key Considerations for Requesting Additional Shares</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In determining the number of shares to be authorized under the 2019 Incentive Plan, as proposed to be amended, the Board considered the following principal factors:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <td style="width: 0.5in"></td>
        <td style="width: 0.25in">&#8226;</td>
        <td><i>Number of Shares Available for Grant under Existing Plan: </i>As of the Record Date, 3,768,849 shares remained available for issuance under the 2019 Incentive Plan. There were no shares available to grant under prior incentive plans.</td>
      </tr>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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        <td><i>Number of Outstanding Awards Under All Plans: </i>As of the Record Date, there were 13,039,382 outstanding stock options, which had a weighted average exercise price of $20.41 and a weighted average remaining contractual life of 7.10 years,
          and there were 917,937 RSU awards outstanding.</td>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.25in">&#8226;</td>
        <td><i>Burn Rate: </i>Burn rate measures our usage of shares for our stock plans as a percentage of our outstanding shares. For 2020, 2019 and 2018, our burn rate was 4.05%, 3.42%, and 1.95%, respectively, resulting in an average annual burn rate
          of 3.14% over a three-year period. The rates were calculated by dividing the number of shares subject to awards granted during the year net of forfeitures and cancellations by the weighted average number of shares outstanding during the year.</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>New Plan Benefits</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Awards under the 2019 Incentive Plan, as proposed to be amended, are discretionary and the administrator has not yet determined to whom future awards will be made and
    the terms and conditions of such awards. As a result, no information is provided concerning the benefits to be delivered under the plan to any individual or group of individuals. Information about awards granted to our named executive officers and
    directors during 2020 can be found under the heading &#8220;Compensation Discussion and Analysis&#8212;2020 Grants of Plan-Based Awards&#8221; and &#8220;Director Compensation&#8212;Grant of Restricted Stock Units,&#8221; respectively. During 2020, awards covering 1,183,319 plan shares
    of Common Stock were granted to our executive officers, awards covering 93,098 plan shares were granted to our non-employee directors and awards covering 2,416,311 shares were granted to our other employees.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>2019 Incentive Plan Summary</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following is a description of the material features of the 2019 Incentive Plan, as proposed to be amended. The following discussion is qualified in all respects by
    reference to the full text of (i)&#160;the plan and Amendment No. 1 thereto, attached as Exhibits&#160;10.5 and 10.5.1, respectively, to the Company&#8217;s Annual Report on Form&#160;10-K for the year ended December&#160;31, 2020, (ii) the Omnibus Amendment to Insmed
    Incorporated Incentive Plans, attached as Exhibit 10.6 to the Company&#8217;s Annual Report on Form 10-K for the year ended December 31, 2020 and (iii)&#160;the Amendment, attached hereto as Appendix&#160;A. The term &#8220;employees&#8221; in the following discussion is used to
    refer to officers and directors and other employees of the Company and its affiliates, where applicable.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><i>Purpose and Eligibility</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The purpose of the 2019 Incentive Plan is to advance the interests of the Company by aligning the individual interests of employees, officers, non-employee directors
    and other service providers, in each case who are selected to be participants, with the interests of Company shareholders, and by providing such individuals with an incentive to continue working toward and contributing to the success and progress of
    the Company. Employees of the Company and its affiliates, members of the Board, and other non-employee advisors or service providers are eligible to be considered for the grant of awards under the 2019 Incentive Plan. As of the Record Date,
    approximately 9 nonemployee directors, 7 executive officers and 545 other employees of the Company were so eligible.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Shares Subject to the 2019 Incentive Plan and to Awards</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If the Amendment is approved, the maximum number of shares of Common Stock authorized under the 2019 Incentive Plan is 10,750,000, including the 2,750,000 shares that
    would be added to the 2019 Incentive Plan under the Amendment, plus any shares of Common Stock subject to outstanding awards under the 2017 Incentive Plan, the 2015 Incentive Plan or the 2013 Incentive Plan, as of the effective date of the 2019
    Incentive Plan, that, after such date, are canceled, terminate unearned, expire, are forfeited or lapse for any reason or are settled in cash without the delivery of shares. Shares of Common Stock issued under the 2019 Incentive Plan may either be
    authorized and unissued shares or previously issued shares acquired by the Company, including shares purchased in the open market. The number of shares of Common Stock available for issuance under the 2019 Incentive Plan will be reduced by (i)&#160;one
    share for each share of Common Stock subject to a stock option or stock appreciation right (SAR) with an exercise or strike price of at least 100% of the fair market value of the underlying Common Stock on the date of grant, and (ii)&#160;1.25 shares for
    each share of Common Stock subject to a full value award (<i>e.g</i>., restricted stock or RSUs).</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The number of shares of Common Stock available for issuance under the 2019 Incentive Plan will be increased to the extent that an award under the 2019 Incentive Plan
    (or any award under the 2017 Incentive Plan, the 2015 Incentive Plan or the 2013 Incentive Plan that is outstanding as of the effective date of the 2019 Incentive Plan) is canceled, terminates unearned, expires, is forfeited, or lapses for any reason,
    or such an award is settled in cash without the delivery of shares to a participant, such that any shares of Common Stock subject to any such award will again be available for the grant of an award pursuant to the 2019 Incentive Plan. Shares will not
    again be available for issuance under the plan if they are tendered in payment of an option exercise price or delivered or withheld to satisfy any tax withholding obligation. Additionally, shares covered by a stock-settled SAR that are not issued upon
    full settlement will also not again be available for issuance under the plan. The payment of dividend equivalents in cash in conjunction with any outstanding awards under the 2019 Incentive Plan will not be counted against the shares available for
    issuance under the 2019 Incentive Plan. Any shares of Common Stock with respect to awards issued under the 2019 Incentive Plan (or an award issued under the 2017 Incentive Plan, the 2015 Incentive Plan or the 2013 Incentive Plan) that again become
    available for future grants will be added back to the share pool (i)&#160;as one share for each share of Common Stock subject to a stock option or SAR, and (ii)&#160;as 1.25 shares for each share of Common Stock subject to a full value award, provided, that
    awards issued under the 2017 Incentive Plan, the 2015 Incentive Plan or the 2013 Incentive Plan will be considered full-value awards if they would have been full-value awards if issued under the 2019 Incentive Plan and added back to the share pool as
    one share in all other cases.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If the Amendment is approved, the aggregate number of shares of Common Stock that may be issued pursuant to the exercise of incentive stock options (ISOs) granted
    under the 2019 Incentive Plan will not exceed 10,750,000, including the 2,750,000 that are added to the 2019 Incentive Plan under the Amendment.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Awards granted or shares issued by the Company in assumption of, or in substitution or exchange for, awards previously granted, or the right or obligation to make
    future awards, by a company acquired by the Company or with which the Company combines will not reduce the shares authorized for issuance under the 2019 Incentive Plan. In addition, in the event that a company acquired by the Company, or with which the
    Company combines, has shares available under a shareholder-approved, pre-existing equity compensation plan, not adopted in contemplation of such acquisition or combination, the shares available for grant pursuant to such pre-existing plan (as adjusted
    in connection with such acquisition or combination) may be used for awards under the 2019 Incentive Plan and will not reduce the shares authorized for issuance under the 2019 Incentive Plan, provided that the awards using such available shares will not
    be made after the last day awards could have been made under the terms of the pre-existing plan absent the acquisition or combination and will not be granted to individuals who were employed by the Company or its subsidiaries at the time the
    acquisition or combination was consummated.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Administration</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The 2019 Incentive Plan is administered by the Compensation Committee, or, in the absence of the Compensation Committee, the Board itself. Any power of the
    administrator may also be exercised by the Board. To the extent that any permitted action taken by the Board conflicts with action taken by the administrator, the Board action will control. The Compensation Committee may by resolution authorize one or
    more officers of the Company to perform any or all things that the administrator is authorized and empowered to do or perform under the 2019 Incentive Plan; provided, however, that such authorization must specify the total number of awards (if any)
    such officer or officers may award pursuant to such delegated authority, and provided further that in no event may an officer of the Company be delegated the authority to grant awards to, or amend awards held by, the individuals who are subject to
    Section&#160;16 of the Exchange Act or report directly to such officer. Additionally, no such officer may grant any awards to himself or herself. The administrator may also delegate any or all aspects of the day-to-day administration of the 2019 Incentive
    Plan to one or more officers or employees of the Company or any subsidiary, and/or to one or more agents.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Subject to the provisions of the 2019 Incentive Plan, the administrator has the authority to select the participants to receive awards and to grant such awards and to
    determine the terms and conditions of awards and the number of shares to be issued pursuant thereto, including conditioning the receipt or vesting of awards upon achievement of performance conditions. All decisions, determinations and interpretations
    by the administrator are final and binding on all participants and all other persons holding or claiming rights under the plan or any award granted thereunder.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Awards</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The 2019 Incentive Plan authorizes the grant of awards of stock options, SARs, restricted stock and RSUs. Any award may be subject to performance conditions as
    determined by the administrator. The terms of awards will be determined by the administrator and set forth in an award agreement. The terms of any awards may vary among participants. Subject to the provisions of the 2019 Incentive Plan, the
    administrator will specify before, at or after the time of grant the provisions governing the effects upon an award of a separation from service or other termination of service. Unless otherwise provided in an award agreement or another agreement,
    including an employment agreement, unvested awards will be forfeited immediately if a participant terminates his or her employment with the Company for any reason. Participants will not have any rights as a shareholder with respect to shares covered by
    an award until the date the participant becomes the holder of record of such shares. Awards granted under the plan are subject to a minimum vesting period of one year, except in the case of substitute awards issued in connection with acquisitions or
    awards that vest in connection with certain acceleration events. Additionally, the administrator has the authority to grant awards covering up to 5% of the plan&#8217;s share pool that are not subject to this minimum vesting requirement. With respect to
    awards that entitle a participant to dividends or dividend equivalents, in no event may such dividends or dividend equivalents, if any, be paid to the participant prior to the vesting of the portion of the award to which such dividends or dividend
    equivalents relate.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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    be either non-qualified stock options or ISOs under Section&#160;422 of the Code. The exercise price of any stock option granted, other than substitute awards, may not be less than 100% of the fair market value of a share of our Common Stock on the date of
    grant (provided that the exercise price of an ISO granted to a participant who owns stock possessing more than 10&#160;percent of the combined voting power of all classes of the Company&#8217;s stock (a 10% Shareholder) will be at least 110% of the fair market
    value on such date). The option exercise price is payable in cash or such other method as determined by the administrator, including an irrevocable commitment by a broker to pay over such amount from a sale of the shares issuable under an option, the
    delivery of previously owned shares of Common Stock or withholding of shares of Common Stock deliverable upon exercise. Vesting may be based on continued employment, passage of time, attainment of age and/or service requirements, and/or satisfaction of
    performance conditions. The term of a stock option will in no event be greater than ten years (or, for an ISO granted to a 10% Shareholder, five years), provided that the term of a non-qualified stock option will be automatically extended if, at the
    time of its scheduled expiration, the participant holding such option is prohibited by law or by the Company&#8217;s insider trading policy from exercising such option. Any such extension will expire on the 30<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup>&#160;day following the date such prohibition no longer applies.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Other than in connection with a change in the Company&#8217;s capitalization, at any time when the exercise price of an option is above the fair market value of a share of
    Common Stock, the Company may not, without shareholder approval: (i)&#160;reduce the exercise price of such option, (ii)&#160;exchange such option for cash, another award or a new option or SAR with a lower exercise price or (iii)&#160;otherwise reprice such option.
    Options may not be granted under the 2019 Incentive Plan in consideration for, and will not be conditioned upon the delivery of shares to the Company in payment of the exercise price and/or tax withholding obligation under, any other option. Holders of
    a stock option will have no voting rights or rights to receive dividends or dividend equivalents with respect to their stock option until they become the holder of record of the underlying shares.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of the Record Date, the fair market value of a share of our Common Stock, determined by the last reported sale price per share on that date as quoted on the Nasdaq
    Global Select Market, was $37.52.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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    retention, vesting and/or settlement of any restricted stock or RSU award will occur at such time and be subject to such terms and conditions as determined by the administrator or under conditions established by the administrator, which may include
    conditions based on continued employment, passage of time, attainment of age and/or service requirements, and/or satisfaction of performance conditions. Participants who receive restricted stock will be entitled to receive all dividends and other
    distributions paid with respect to those shares unless determined otherwise by the administrator. The administrator will determine whether such dividends or distributions will be automatically reinvested in additional restricted stock and/or subject to
    the same restrictions as the underlying restricted stock, or whether such dividends or distributions will be paid in cash. Unless otherwise set forth in the award agreement, prior to the time shares are issued to a participant under an RSU, the Company
    will pay or accrue dividend equivalents on each date that dividends are paid, and such dividend equivalents will be paid at the time specified in the award agreement. As described above, no dividends or dividend equivalents may be paid with respect to
    an award of restricted stock or RSUs prior to the vesting of the portion of the award to which such dividends or dividend equivalents relate. Unless otherwise determined by the administrator, participants holding shares of restricted stock may exercise
    full voting rights with respect to those shares during the period of restriction. Participants holding RSUs will not have voting rights with respect to the underlying shares until they become the holder of record of the underlying shares.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Stock Appreciation Rights.</i></b></font> A SAR entitles the participant, upon
    settlement, to receive a payment based on the excess of the aggregate market price of a specified number of shares of Common Stock at the time of the exercise over the exercise price of the right. SARs may be granted on a stand-alone basis or in tandem
    with a related stock option. The exercise price may not be less than the fair market value of a share of our Common Stock on the date of grant. A SAR granted in tandem with a stock option will have an exercise price equal to the exercise price of the
    stock option to which it relates. The administrator will determine the vesting requirements and the payment and other terms of a SAR, including the effect of termination of service of a participant. Vesting may be based on continued employment, passage
    of time, attainment of age and/or service requirements, and/or satisfaction of performance conditions. Other than in connection with a change in the Company&#8217;s capitalization, at any time when the exercise price of a SAR is above the fair market value
    of a share of Common Stock, the Company may not, without shareholder approval: (i)&#160;reduce the exercise price of such SAR, (ii)&#160;exchange such SAR for cash, another award or a new option or SAR with a lower exercise price or (iii)&#160;otherwise reprice such
    SAR. Holders of a SAR will have no voting rights or rights to receive dividends or dividend equivalents with respect to their SAR until they become the holder of record of the underlying shares.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Adjustment and Change in Control</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The number and kind of shares of Common Stock available for issuance (including under any awards then outstanding), and the number and kind of shares of Common Stock
    subject to the limits set forth in the 2019 Incentive Plan, will be equitably adjusted by the administrator to reflect any reorganization, reclassification, combination of shares, stock split, reverse stock split, spin-off, dividend or distribution of
    securities, property or cash (other than regular, quarterly cash dividends), or any other event or transaction that affects the number or kind of shares of Common Stock outstanding. Such adjustment may be designed to comply with Section&#160;424 of the Code
    or may be designed to treat the shares available under the 2019 Incentive Plan and subject to awards as if they were all outstanding on the record date for such event or transaction or to increase the number of such shares to reflect a deemed
    reinvestment in shares of the amount distributed to the Company&#8217;s security holders. The terms of any outstanding award will also be equitably adjusted by the administrator as to price, number or kind of shares subject to such award, vesting, and other
    terms to reflect the foregoing events, which adjustments need not be uniform as between different awards or different types of awards. No fractional shares of Common Stock will be issued pursuant to such an adjustment. In the event there is any other
    change in the number or kind of outstanding shares of Common Stock, or any stock or other securities into which such Common Stock will have been changed, or for which it will have been exchanged, by reason of a change in control, other merger,
    consolidation or otherwise, then the administrator will determine the appropriate and equitable adjustment to be effected, which adjustments need not be uniform between different awards or different types of awards. In addition, in the event of such
    change, the administrator may accelerate the time or times at which any award may be exercised, consistent with and as otherwise permitted under Section&#160;409A of the Code, and may provide for cancellation of such accelerated awards that are not
    exercised within a time prescribed by the administrator in its sole discretion.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <div style="page-break-before:always; margin-top: 6pt; margin-bottom: 12pt">
    <p style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt"></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise expressly provided for in an award agreement or another agreement, including an employment agreement, in the event of a change in control, unless
    provision is made in connection with the change in control for (i) assumption of awards previously granted or (ii) substitution for such awards, (A) the administrator will make an adjustment to any or all awards as the administrator deems appropriate
    to reflect such change in control or (B) (1) in the case of an option or SAR, the participant will have the ability to exercise such option or SAR, including any portion of the option or SAR not previously exercisable, and the unexercised portion of
    such option or SAR will be cancelled upon on the consummation of the change in control; (2) in the case of an award subject to performance conditions, the participant will have the right to receive a payment based on performance through a date
    determined by the administrator prior to the change in control (unless such performance cannot be determined, in which case the participant will have the right to receive a payment equal to the target amount payable); and (3) in the case of outstanding
    restricted stock and/or RSUs not subject to performance conditions, all conditions to the grant, issuance, retention, vesting or transferability of, or any other restrictions applicable to, such award will immediately lapse.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise expressly provided for in an award agreement or another agreement, including an employment agreement, or under the terms of a transaction constituting
    a change in control, the following will occur upon a participant&#8217;s involuntary termination of employment or other service within 24&#160;months following a change in control, provided that such termination does not result from disability, cause or gross
    misconduct: (i)&#160;in the case of an option or SAR, the participant will have the ability to exercise such option or SAR, including any portion of the option or SAR not previously exercisable, and the option or SAR will remain exercisable for a period of
    three years following such termination (or until expiration, if earlier), (ii)&#160;in the case of an award subject to performance conditions, the participant will have the right to receive a payment based on performance through a date determined by the
    administrator prior to the change in control (unless such performance cannot be determined, in which case the participant will have the right to receive a payment equal to the target amount payable), and (iii)&#160;in the case of outstanding restricted
    stock and/or RSUs not subject to performance conditions, all conditions to the grant, issuance, retention, vesting or transferability of, or any other restrictions applicable to, such award will immediately lapse.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Transferability</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No award may be sold, transferred for value, pledged, assigned, or otherwise alienated or hypothecated by a participant other than by will or the laws of descent and
    distribution; provided, however, that a participant may, with the prior approval of the Company&#8217;s Chief Legal Officer or Chief Financial Officer or one of their designees (provided that no such person may approve a transfer by such person), transfer an
    award, other than an ISO, for no consideration, to a family member (as defined in the General Instructions to Form S-8 under the Securities Act of 1933), in each case, with respect to whom such award or the exercise thereof (as applicable) is covered
    by an effective registration statement under the Securities Act of 1933 (collectively, the Permitted Transferees). Any award transferred to a Permitted Transferee shall be further transferable only by will or the laws of descent and distribution or,
    for no consideration, to another Permitted Transferee of the participant. During the participant&#8217;s lifetime, each option or SAR shall be exercisable only by the participant or by his or her Permitted Transferee to whom such options or SARs have been
    transferred during the participant&#8217;s lifetime and, after the participant&#8217;s death, with respect to outstanding options, by beneficiaries of the participant, by any such Permitted Transferee or as permitted by the administrator.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Duration of the 2019 Incentive Plan</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Awards may not be granted under the 2019 Incentive Plan after the tenth anniversary of the adoption by the Board of the 2019 Incentive Plan. Notwithstanding the
    foregoing, the 2019 Incentive Plan may be terminated at such earlier time as the Board may determine. Termination of the 2019 Incentive Plan will not affect the rights and obligations of the participants and the Company arising under awards granted
    prior to such termination.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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    </table>
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    <p style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt"></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Amendment and Termination</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Subject to limitations imposed by law, the Board may amend or terminate the 2019 Incentive Plan at any time and the administrator may amend or alter any agreement or
    other document evidencing an award made under the 2019 Incentive Plan. However, no such amendment may deprive the recipient of an award previously granted under the 2019 Incentive Plan of any rights thereunder without his or her consent, unless the
    administrator determines that the amendment (i)&#160;is required or advisable to satisfy any law or regulation or avoid adverse financial accounting consequences, or (ii)&#160;is not reasonably likely to significantly diminish the benefits provided under the
    award, or that any diminishment has been adequately compensated. Notwithstanding the foregoing, no such amendment shall, without the approval of the shareholders of the Company:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
        <td style="width: 0.5in">(a)</td>
        <td>increase the maximum number of shares of Common Stock for which awards may be granted under the 2019 Incentive Plan;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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        <td>reduce the price at which options may be granted below the price provided for in the 2019 Incentive Plan;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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        <td>reprice outstanding options or SARs;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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        <td>extend the term of the 2019 Incentive Plan;</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
        <td style="width: 0.5in"></td>
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        <td>change the class of persons eligible to be participants; or</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0" width="100%">

      <tr style="vertical-align: top">
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        <td style="width: 0.5in">(f)</td>
        <td>otherwise amend the 2019 Incentive Plan in any manner requiring shareholder approval by law or the rules of any stock exchange or market or quotation system on which the Common Stock is traded, listed or quoted.</td>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Recoupment Policy</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The administrator has the authority to cause a participant or an award under the plan to be subject to the Company&#8217;s recovery, recoupment, clawback and/or other
    forfeiture policies, as maintained by the Company from time to time.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Federal Income Tax Treatment</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following discussion summarizes the material U.S. federal income tax consequences to the Company and the participants in connection with the 2019 Incentive Plan
    under existing applicable provisions of the Code and the accompanying regulations. The discussion is general in nature and does not address issues relating to the income tax circumstances of any individual participant. The discussion is based on
    federal income tax laws in effect on the date of this Proxy Statement and is, therefore, subject to possible future changes in the law. The discussion does not address the consequences of state, local or foreign tax laws.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Nonqualified Options</i></font>&#8212;An employee will not recognize any income upon receipt of
    a nonqualified stock option, and the Company will not be entitled to a deduction for federal income tax purposes at the time of grant. Ordinary income will be realized by the holder at the time the nonqualified stock option is exercised and the shares
    are transferred to the employee. The amount of such taxable income, in the case of a nonqualified stock option, will be the excess, if any, of the fair market value of the shares on the date of exercise over the exercise price. The Company will
    generally be entitled to a tax deduction in an amount equal to the ordinary income that an employee recognizes upon exercise.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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    income for federal income tax purposes upon receipt of the ISO, and the Company will not realize a deduction for federal income tax purposes. The holder generally will not be taxed upon exercise, but the excess, if any, of the fair market value of the
    stock on the date of exercise over the option exercise price may subject the holder to the alternative minimum tax. If the holder does not dispose of the ISO shares within two years from the date the option was granted or within one year after the
    shares were transferred to him on exercise of the option, then that portion of the gain on the sale of the shares that is equal to the difference between the sales price and the option exercise price will be treated as a long-term capital gain. The
    Company will not be entitled to a deduction either at the time the employee exercises the ISO or subsequently sells the ISO shares. However, if the employee sells the ISO shares within two years after the date the ISO is granted or within one year
    after the date the ISO is exercised, then the sale is considered a disqualifying sale, and the spread on exercise will be taxed as ordinary income. The balance of the gain will be treated as long- or short-term capital gain depending on the length of
    time the employee held the stock. If the shares decline in value after the date of exercise, the compensation income will be limited to the difference between the sale price and the amount paid for the shares. The tax will be imposed in the year the
    disqualifying sale is made. The Company will be entitled to a deduction equal to the ordinary income recognized by the employee.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">With respect to both nonqualified stock options and ISOs, special rules apply if an employee uses shares already held by the employee to pay the exercise price or if
    the shares received upon exercise of the option are subject to a substantial risk of forfeiture by the employee.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  </div>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Restricted Stock</i></font>&#8212;Employees receiving restricted stock will not recognize any
    income upon receipt of the restricted stock. Ordinary income will be realized by the holder at the time that the restrictions on transfer are removed or expire. The amount of ordinary income will be equal to the fair market value of the shares on the
    date that the restrictions on transfer are removed or expire. The Company will be entitled to a deduction at the same time and in the same amount as the ordinary income the employee is deemed to have realized. However, no later than 30&#160;days after an
    employee receives the restricted stock, the employee may elect to recognize taxable ordinary income in an amount equal to the fair market value of the shares at the time of receipt. Provided that the election is made in a timely manner, when the
    restrictions on the shares lapse, the employee will not recognize any additional income. If the employee forfeits the shares to the Company, the employee may not claim a deduction with respect to the income recognized as a result of the election.</p>
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    Accordingly, awards granted to the Company&#8217;s covered employees under the 2019 Incentive Plan may not be fully deductible.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Equity Compensation Plan Information</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In 2020, we made stock-based awards from our 2019 Incentive Plan, and have outstanding grants under our 2017 Incentive Plan, 2015 Incentive Plan, 2013 Incentive Plan
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The 2019 Incentive Plan was adopted by the Board and approved by our shareholders on May&#160;16, 2019. Under the terms of the 2019 Incentive Plan, we are authorized to
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <tr style="vertical-align: top; text-align: left">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table presents information as of December&#160;31, 2020, with respect to the Plans.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <table style="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: bottom">
        <td style="padding-bottom: 1pt; text-indent: -10pt; padding-left: 10pt; white-space: nowrap; font-weight: bold"><font style="border-bottom: Black 1pt solid;">Plan Category</font></td>
        <td style="white-space: nowrap; font-weight: bold; padding-bottom: 1pt">&#160;</td>
        <td style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of Securities<br>
          to be Issued<br>
          Upon Exercise<br>
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        <td style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted Average<br>
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        <td style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of Securities<br>
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          for Future Issuance<br>
          Under Equity<br>
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        <td style="border-bottom: Black 1pt solid; text-indent: -10pt; padding-left: 10pt; text-align: left">Equity Compensation Plans Approved by&#160;Shareholders:</td>
        <td>&#160;</td>
        <td style="text-align: right">&#160;</td>
        <td>&#160;</td>
        <td style="text-align: right">&#160;</td>
        <td>&#160;</td>
        <td style="text-align: right">&#160;</td>
      </tr>
      <tr style="vertical-align: bottom; background-color: White">
        <td style="text-indent: -10pt; padding-left: 20pt; width: 43%">2019 Incentive Plan(2)</td>
        <td style="width: 1%">&#160;</td>
        <td style="width: 18%; text-align: right">3,412,889</td>
        <td style="width: 1%">&#160;</td>
        <td style="width: 18%; text-align: right">$23.85</td>
        <td style="width: 1%; font-weight: bold">&#160;</td>
        <td style="width: 18%; text-align: right">5,200,879</td>
      </tr>
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        <td style="text-indent: -10pt; padding-left: 20pt">2017 Incentive Plan(3)</td>
        <td>&#160;</td>
        <td style="text-align: right">3,682,641</td>
        <td>&#160;</td>
        <td style="text-align: right">$18.13</td>
        <td>&#160;</td>
        <td style="text-align: right">&#8212;</td>
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        <td style="text-indent: -10pt; padding-left: 20pt">2015 Incentive Plan(4)</td>
        <td>&#160;</td>
        <td style="text-align: right">2,948,915</td>
        <td>&#160;</td>
        <td style="text-align: right">$15.74</td>
        <td>&#160;</td>
        <td style="text-align: right">&#8212;</td>
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      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
        <td style="text-indent: -10pt; padding-left: 20pt; text-align: left">2013 Stock Incentive Plan(5)</td>
        <td>&#160;</td>
        <td style="text-align: right">1,082,468</td>
        <td>&#160;</td>
        <td style="text-align: right">$15.14</td>
        <td>&#160;</td>
        <td style="text-align: right">&#8212;</td>
      </tr>
      <tr style="vertical-align: bottom; background-color: White">
        <td style="text-indent: -10pt; padding-left: 20pt; text-align: left">2000 Stock Incentive Plan(6)</td>
        <td>&#160;</td>
        <td style="text-align: right">403,800</td>
        <td>&#160;</td>
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        <td>&#160;</td>
        <td style="text-align: right">&#8212;</td>
      </tr>
      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
        <td style="border-bottom: Black 1pt solid; text-indent: -10pt; padding-left: 10pt; text-align: left">Equity Compensation Plans Not<br>
          Approved&#160;by Shareholders:</td>
        <td>&#160;</td>
        <td style="text-align: right">&#160;</td>
        <td>&#160;</td>
        <td style="text-align: right">&#160;</td>
        <td>&#160;</td>
        <td style="text-align: right">&#8212;</td>
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      <tr style="vertical-align: bottom; background-color: White">
        <td style="padding-bottom: 1pt; text-indent: -10pt; padding-left: 20pt; text-align: left">Individual Compensation<br>
          Arrangements(7)</td>
        <td style="padding-bottom: 1pt">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">1,577,080</td>
        <td style="padding-bottom: 1pt">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">$20.42</td>
        <td style="padding-bottom: 1pt">&#160;</td>
        <td style="border-bottom: Black 1pt solid; text-align: right">&#8212;</td>
      </tr>
      <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
        <td style="padding-bottom: 2.5pt; text-indent: -10pt; padding-left: 30pt">Total</td>
        <td style="padding-bottom: 2.5pt">&#160;</td>
        <td style="border-bottom: Black 2.5pt double; text-align: right">13,107,793</td>
        <td style="padding-bottom: 2.5pt">&#160;</td>
        <td style="border-bottom: Black 2.5pt double; text-align: right">&#160;</td>
        <td style="padding-bottom: 2.5pt">&#160;</td>
        <td style="border-bottom: Black 2.5pt double; text-align: right">5,200,879</td>
      </tr>

  </table>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="border-bottom: Black 1pt solid">&#160;</td>
        <td style="border-bottom: Black 1pt solid">&#160;</td>
      </tr>
      <tr style="vertical-align: top">
        <td style="padding-top: 2pt; width: 0.5in">(1)</td>
        <td style="padding-top: 2pt">Does not include outstanding RSUs, which do not require the payment of any exercise price upon their vesting.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 0.5in">(2)</td>
        <td>Represents shares of Common Stock issuable upon the exercise of outstanding stock options and vesting of outstanding RSUs granted under our 2019 Incentive Plan.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 0.5in">(3)</td>
        <td>Represents shares of Common Stock issuable upon the exercise of outstanding stock options and vesting of outstanding RSUs granted under our 2017 Incentive Plan. To the extent that awards granted under the 2017 Incentive Plan terminate unearned,
          expire, or are canceled, forfeited, lapse for any reason, or are settled in cash without the delivery of shares, the shares of Common Stock underlying such grants will again become available for purposes of the 2019 Incentive Plan.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 0.5in">(4)</td>
        <td>Represents shares of Common Stock issuable upon the exercise of outstanding stock options granted under our 2015 Incentive Plan. To the extent that awards granted under the 2015 Incentive Plan terminate unearned, expire, or are canceled,
          forfeited, lapse for any reason, or are settled in cash without the delivery of shares, the shares of Common Stock underlying such grants will again become available for purposes of the 2019 Incentive Plan.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 0.5in">(5)</td>
        <td>Represents shares of Common Stock issuable upon the exercise of outstanding stock options granted under our 2013 Stock Incentive Plan. To the extent that awards granted under the 2013 Incentive Plan terminate unearned, expire, or are canceled
          or, forfeited, lapse for any reason, or are settled in cash without the delivery of shares, the shares of Common Stock underlying such grants will again become available for purposes of the 2019 Incentive Plan.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 0.5in">(6)</td>
        <td>Represents shares of Common Stock issuable upon the exercise of outstanding stock options granted under the 2000 Stock Incentive Plan.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
        <td style="width: 0.5in">(7)</td>
        <td>Represents outstanding inducement grants of stock options we made in connection with the hiring of various employees. The vesting schedule for the shares of Common Stock subject to these options is as follows: 25% on the first anniversary of
          the date of grant and 12.5% of the shares vesting on each six-month anniversary thereafter until the fourth anniversary of the date of grant.</td>
      </tr>

  </table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Vote Required for Approval of this Proposal</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Approval of the Amendment requires the affirmative vote of a majority of the votes cast at the Annual Meeting. Abstentions and broker non-votes will not have an effect
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Recommendation</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>THE BOARD RECOMMENDS THAT YOU VOTE &#8220;FOR&#8221; THE APPROVAL OF THE AMENDMENT TO THE 2019 INCENTIVE PLAN.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <tr style="vertical-align: top; text-align: left">
          <td style="width: 33%">&#160;</td>
          <td style="text-align: center; width: 34%">&#160;<!-- Field: Sequence; Type: Arabic; Name: PageNo -->57<!-- Field: /Sequence --></td>
          <td style="width: 33%">&#160;</td>
        </tr>

    </table>
  </div>
  <div style="page-break-before:always; margin-top: 6pt; margin-bottom: 12pt">
    <p style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt"></p>
  </div>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>&#160;</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a016"></a><b>PROPOSALS FOR 2022 ANNUAL MEETING</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Shareholder proposals intended for inclusion in our proxy statement for the 2022 Annual Meeting of Shareholders must be received at our offices no later than the close
    of business on December&#160;1, 2021. All such proposals must comply with Rule&#160;14a-8 under the Exchange Act and must be submitted to the Corporate Secretary, Insmed Incorporated, 700 US Highway 202/206, Bridgewater, New Jersey 08807.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Under our Bylaws, any shareholder (as defined in our Bylaws) who wishes to present other business or nominate a director candidate at the 2022 Annual Meeting of
    Shareholders must give timely written notice of any such business or nomination to our Corporate Secretary in advance of the meeting. Such written notice must comply with the requirements in our Bylaws and must be given, either by personal delivery or
    by United States registered or certified mail, postage prepaid, to our Corporate Secretary at the address given above no later than 120&#160;days nor more than 150&#160;days before the anniversary of the immediately preceding year&#8217;s annual meeting. Accordingly,
    for the 2022 Annual Meeting of Shareholders, our Corporate Secretary must receive such written notice no earlier than December&#160;13, 2021 and no later than January&#160;12, 2022. If the date of the 2021 Annual Meeting of Shareholders is more than 30&#160;days
    before or more than 60&#160;days after May&#160;12, 2022 (the anniversary of this year&#8217;s Annual Meeting), then the written notice must be received no later than the 120th&#160;day prior to such Annual Meeting or, if later, the 10th&#160;day following the day on which
    public disclosure of the date of such Annual Meeting was first made. If a shareholder fails to meet these requirements or fails to satisfy the requirements of Rule&#160;14a-4 under the Exchange Act, the named proxies may exercise discretionary voting
    authority under proxies that we solicit to vote on any such business or nomination in accordance with their best judgment. Our Bylaws are available on our website at www.insmed.com under the heading &#8220;Investor Relations&#8212;Corporate Governance&#8221; or by
    submitting a written request to the Corporate Secretary, Insmed Incorporated, 700 US Highway 202/206, Bridgewater, New Jersey 08807.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
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        <tr style="vertical-align: top; text-align: left">
          <td style="width: 33%">&#160;</td>
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          <td style="width: 33%">&#160;</td>
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    </table>
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  <div style="page-break-before:always; margin-top: 6pt; margin-bottom: 12pt">
    <p style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt"></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a017"></a><b>ANNUAL REPORT ON FORM 10-K</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>We will provide without charge to each person to whom this Proxy Statement has been made available on the written request of such person, a printed copy of our
      Annual Report on Form&#160;10-K for the year ended December&#160;31, 2020, including the financial statements and financial statement schedules. Requests should be directed to Ms.&#160;Christine Pellizzari, Corporate Secretary, Insmed Incorporated, 700 US Highway
      202/206, Bridgewater, New Jersey, 08807, (908)&#160;977-9900. In connection with any such request, we will provide a list of exhibits to the Annual Report on Form&#160;10-K for the year ended December&#160;31, 2020, and will provide copies of any such exhibit upon
      the payment of a reasonable fee.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><a name="a018"></a><b>SEPARATE COPIES FOR BENEFICIAL HOLDERS</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
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    our Corporate Secretary as described above, and we will promptly provide a separate copy. If you are the beneficial owner, but not the record holder, of the Company&#8217;s shares and wish to receive only one copy of our proxy materials in the future, you
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><a name="a019"></a><b>Appendix&#160;A</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>AMENDMENT NO. 2</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>TO THE</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>INSMED INCORPORATED 2019 INCENTIVE PLAN</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">April 1, 2021</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">WHEREAS, Insmed Incorporated (the &#8220;<i>Company</i>&#8221;) sponsors and maintains the Insmed Incorporated 2019 Incentive Plan (as amended by Amendment No. 1 thereto, dated
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        <td>The reference to &#8220;8,000,000&#8221; in Section&#160;5(a) of the Plan is hereby amended and replaced with &#8220;10,750,000&#8221;.</td>
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