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Summary of Significant Accounting Policies - Narrative (Details) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 04, 2021 shares | Aug. 31, 2021 sale shares | Sep. 30, 2021 shares | Jun. 30, 2022 USD ($) | Jun. 30, 2021 USD ($) | Dec. 31, 2021 USD ($) security | Jan. 01, 2022 USD ($) | May 31, 2021 USD ($) | Jan. 31, 2018 USD ($)
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Marketable securities, additional |  |  |  | $ (99,700,000) |  |  |  |  |
Fair value transfers in or out of Level 1, Level 2, or Level 3 |  |  |  | 0 | $ 0 |  |  |  |
Current available-for-sale securities |  |  |  | 138,800,000 |  |  |  |  |
Noncurrent available-for-sale securities |  |  |  | 9,800,000 |  |  |  |  |
Unrealized loss |  |  |  | $ (1,300,000) |  |  |  |  |
Unrealized gain or loss | security |  |  |  |  |  | 0 |  |  |
Accounting Standards Update [Extensible Enumeration] |  |  |  | Accounting Standards Update 2020-06 |  | Accounting Standards Update 2020-06 |  |  |
Debt, long-term |  |  |  | $ 783,977,000 |  | $ 566,588,000 |  |  |
Unamortized debt issuance costs |  |  |  | 16,023,000 |  | 11,539,000 |  |  |
Accumulated deficit |  |  |  | (2,405,310,000) |  | (2,265,243,000) |  |  |
Additional paid-in capital |  |  |  | 2,449,281,000 |  | 2,673,556,000 |  |  |
Accounting Standards Update 2020-06 |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  |  | $ 50,200,000 |  |
Cumulative Effect, Period of Adoption, Adjustment | Accounting Standards Update 2020-06 |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Debt, long-term |  |  |  |  |  |  | 221,900,000 |  |
Unamortized debt issuance costs |  |  |  |  |  |  | 6,100,000 |  |
Deferred tax liabilities |  |  |  |  |  |  | 1,400,000 |  |
Additional paid-in capital |  |  |  |  |  |  | $ (264,600,000) |  |
Carrying Value | Recurring basis |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Deferred consideration |  |  |  | 10,800,000 |  | 14,900,000 |  |  |
Level 2 | Fair Value | Recurring basis |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Deferred consideration |  |  |  | 10,800,000 |  | $ 14,900,000 |  |  |
0.75% convertible senior notes due 2028 | Level 2 | Fair Value | Recurring basis |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes |  |  |  | 496,000,000 |  |  |  |  |
0.75% convertible senior notes due 2028 | Level 2 | Carrying Value | Recurring basis |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes |  |  |  | $ 561,600,000 |  |  |  |  |
0.75% convertible senior notes due 2028 | Convertible Notes |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from issuance of 0.75% convertible senior notes due 2028 |  |  |  | 0.75% |  |  |  |  |
Unamortized debt issuance costs |  |  |  | $ 13,400,000 |  |  |  | $ 15,700,000 |
1.75% convertible senior notes due 2025 | Level 2 | Fair Value | Recurring basis |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes |  |  |  | 208,300,000 |  |  |  |  |
1.75% convertible senior notes due 2025 | Level 2 | Carrying Value | Recurring basis |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes |  |  |  | $ 222,400,000 |  |  |  |  |
1.75% convertible senior notes due 2025 | Convertible Notes |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from issuance of 0.75% convertible senior notes due 2028 |  |  |  | 1.75% |  |  |  |  |
Unamortized debt issuance costs |  |  |  | $ 2,600,000 |  |  |  |  | $ 14,200,000
Development and regulatory milestones |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Weighted-average probability of reaching milestone, percentage |  |  |  | 42.00% |  |  |  |  |
Accrued Liabilities, Current |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Deferred consideration |  |  |  | $ 3,500,000 |  |  |  |  |
Other Noncurrent Liabilities |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Deferred consideration |  |  |  | 7,300,000 |  |  |  |  |
Motus |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Shares issued in acquisition (in shares) | shares | 2,889,367 |  | 2,889,367 |  |  |  |  |  |
Shares issued upon milestone achievements (in shares) | shares | 5,348,572 |  |  |  |  |  |  |  |
Motus | Level 2 |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Deferred consideration |  |  |  | $ 10,800,000 |  |  |  |  |
Motus | Priority review voucher milestone |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Potential payout percentage |  | 50.00% |  |  |  |  |  |  |
Potential payout, average sales prices, percentage |  | 50.00% |  |  |  |  |  |  |
Number of publicly disclosed sales used to determine average sales price owed to equity holders | sale |  | 3 |  |  |  |  |  |  |
Motus | Second anniversary of closing date |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Shares issued in acquisition (in shares) | shares | 184,433 |  |  |  |  |  |  |  |
Motus | Third anniversary of closing date |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Shares issued in acquisition (in shares) | shares | 184,433 |  |  |  |  |  |  |  |
Motus | First anniversary of closing date |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Shares issued in acquisition (in shares) | shares | 184,433 |  |  |  |  |  |  |  |
AlgaeneX |  |  |  |  |  |  |  |  |
Fair Value Measurement Inputs and Valuation Techniques [Line Items] |  |  |  |  |  |  |  |  |
Shares issued upon milestone achievements (in shares) | shares |  | 368,867 |  |  |  |  |  |  |

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