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Summary of Significant Accounting Policies - Narrative (Details)
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Aug. 04, 2021
shares
Aug. 31, 2021
sale
shares
Sep. 30, 2021
shares
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
security
Jan. 01, 2022
USD ($)
May 31, 2021
USD ($)
Jan. 31, 2018
USD ($)
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Marketable securities, additional       $ (99,700,000)          
Fair value transfers in or out of Level 1, Level 2, or Level 3       0 $ 0        
Current available-for-sale securities       138,800,000          
Noncurrent available-for-sale securities       9,800,000          
Unrealized loss       $ (1,300,000)          
Unrealized gain or loss | security           0      
Accounting Standards Update [Extensible Enumeration]       Accounting Standards Update 2020-06   Accounting Standards Update 2020-06      
Debt, long-term       $ 783,977,000   $ 566,588,000      
Unamortized debt issuance costs       16,023,000   11,539,000      
Accumulated deficit       (2,405,310,000)   (2,265,243,000)      
Additional paid-in capital       2,449,281,000   2,673,556,000      
Accounting Standards Update 2020-06                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Accumulated deficit             $ 50,200,000    
Cumulative Effect, Period of Adoption, Adjustment | Accounting Standards Update 2020-06                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Debt, long-term             221,900,000    
Unamortized debt issuance costs             6,100,000    
Deferred tax liabilities             1,400,000    
Additional paid-in capital             $ (264,600,000)    
Carrying Value | Recurring basis                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Deferred consideration       10,800,000   14,900,000      
Level 2 | Fair Value | Recurring basis                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Deferred consideration       10,800,000   $ 14,900,000      
0.75% convertible senior notes due 2028 | Level 2 | Fair Value | Recurring basis                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Convertible senior notes       496,000,000          
0.75% convertible senior notes due 2028 | Level 2 | Carrying Value | Recurring basis                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Convertible senior notes       $ 561,600,000          
0.75% convertible senior notes due 2028 | Convertible Notes                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Proceeds from issuance of 0.75% convertible senior notes due 2028       0.75%          
Unamortized debt issuance costs       $ 13,400,000       $ 15,700,000  
1.75% convertible senior notes due 2025 | Level 2 | Fair Value | Recurring basis                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Convertible senior notes       208,300,000          
1.75% convertible senior notes due 2025 | Level 2 | Carrying Value | Recurring basis                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Convertible senior notes       $ 222,400,000          
1.75% convertible senior notes due 2025 | Convertible Notes                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Proceeds from issuance of 0.75% convertible senior notes due 2028       1.75%          
Unamortized debt issuance costs       $ 2,600,000         $ 14,200,000
Development and regulatory milestones                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Weighted-average probability of reaching milestone, percentage       42.00%          
Accrued Liabilities, Current                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Deferred consideration       $ 3,500,000          
Other Noncurrent Liabilities                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Deferred consideration       7,300,000          
Motus                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Shares issued in acquisition (in shares) | shares 2,889,367   2,889,367            
Shares issued upon milestone achievements (in shares) | shares 5,348,572                
Motus | Level 2                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Deferred consideration       $ 10,800,000          
Motus | Priority review voucher milestone                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Potential payout percentage   50.00%              
Potential payout, average sales prices, percentage   50.00%              
Number of publicly disclosed sales used to determine average sales price owed to equity holders | sale   3              
Motus | Second anniversary of closing date                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Shares issued in acquisition (in shares) | shares 184,433                
Motus | Third anniversary of closing date                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Shares issued in acquisition (in shares) | shares 184,433                
Motus | First anniversary of closing date                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Shares issued in acquisition (in shares) | shares 184,433                
AlgaeneX                  
Fair Value Measurement Inputs and Valuation Techniques [Line Items]                  
Shares issued upon milestone achievements (in shares) | shares   368,867