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Consolidated Statements of Comprehensive Loss (unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Statement of Comprehensive Income [Abstract]        
Product revenues, net $ 65,221 $ 45,366 $ 118,328 $ 85,580
Revenue from Contract with Customer, Product and Service [Extensible List] Product [Member] Product [Member] Product [Member] Product [Member]
Operating expenses:        
Cost of product revenues (excluding amortization of intangible assets) $ 16,395 $ 10,837 $ 28,586 $ 20,681
Cost, Product and Service [Extensible List] Product [Member] Product [Member] Product [Member] Product [Member]
Research and development $ 88,527 $ 64,655 $ 172,883 $ 126,045
Selling, general and administrative 59,974 57,177 116,722 108,727
Amortization of intangible assets 1,263 1,263 2,526 2,526
Change in fair value of deferred and contingent consideration liabilities (12,622) 0 (24,240) 0
Total operating expenses 153,537 133,932 296,477 257,979
Operating loss (88,316) (88,566) (178,149) (172,399)
Investment income 835 34 972 67
Interest expense (3,357) (10,319) (6,648) (17,878)
Loss on extinguishment of debt 0 (17,689) 0 (17,689)
Other expense, net (4,306) (159) (5,555) (202)
Loss before income taxes (95,144) (116,699) (189,380) (208,101)
Provision for income taxes 501 622 886 861
Net loss $ (95,645) $ (117,321) $ (190,266) $ (208,962)
Basic net loss per share (in dollars per share) $ (0.80) $ (1.07) $ (1.60) $ (1.97)
Diluted net loss per share (in dollars per share) $ (0.80) $ (1.07) $ (1.60) $ (1.97)
Weighted average basic common shares outstanding (in shares) 119,602 109,580 119,267 106,328
Weighted average diluted common shares outstanding (in shares) 119,602 109,580 119,267 106,328
Net loss $ (95,645) $ (117,321) $ (190,266) $ (208,962)
Other comprehensive income (loss):        
Foreign currency translation (loss) income (208) 334 (702) 231
Unrealized loss on marketable securities (491) 0 (1,195) 0
Total comprehensive loss $ (96,344) $ (116,987) $ (192,163) $ (208,731)