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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Schedule of Loss Before Income Taxes in the US and Globally

The Company's loss before income taxes in the US and globally was as follows (in thousands):

			Years Ended December 31,
			2023						2022						2021
US			$	(666,181)					$	(406,262)					$	(348,845)
Foreign			(80,831)						(73,889)						(87,567)
Total			$	(747,012)					$	(480,151)					$	(436,412)

Schedule of Components Income Tax Provision (Benefit)

The Company's income tax provision (benefit) consisted of the following (in thousands):

			Years Ended December 31,
			2023						2022						2021
Current:
Federal			$	—					$	—					$	—
State			378						269						104
Foreign			2,231						1,345						1,585
			2,609						1,614						1,689
Deferred:
Federal			(13)						13						(2,835)
State			(41)						(244)						(612)
Foreign			—						—						—
			(54)						(231)						(3,447)
Total			$	2,555					$	1,383					$	(1,758)

Schedule of Reconciliation Between Federal Statutory Tax Rate and Effective Tax Rate

The reconciliation between the federal statutory tax rates and the Company's effective tax rate is as follows:

			Years Ended December 31,
			2023						2022						2021
Statutory federal tax rate			21		%				21		%				21		%
Permanent items			(1)		%				—		%				(1)		%
State income taxes, net of federal benefit			3		%				1		%				4		%
R&D and other tax credits			3		%				3		%				4		%
Foreign income taxes			(1)		%				—		%				(1)		%
Change in valuation allowance			(21)		%				(22)		%				(27)		%
Asset acquisitions (see Note 18)			(3)		%				—		%				—		%
Stock-based compensation			(1)		%				(2)		%				—		%
Other			—		%				(1)		%				—		%
Effective tax rate			—		%				—		%				—		%

Schedule of Components of Deferred Tax Assets and Liabilities

The components of the deferred tax assets and liabilities consist of the following:

			As of December 31,
			2023						2022
Deferred tax assets:
Net operating loss carryforwards			$	563,869					$	499,029
General business credits			182,006						157,181
Product license			3,867						4,317
Inventory			2,341						1,470
Lease liabilities			12,000						12,965
Stock-based compensation			27,916						23,724
Capitalized R&D			115,299						56,275
Other			19,286						15,001
Deferred tax assets			926,584						769,962
Valuation allowance			(904,078)						(745,135)
Deferred tax assets, net of valuation allowance			$	22,506					$	24,827
Deferred tax liabilities:
Intangibles			$	(13,006)					$	(13,739)
Right-of-use assets			(9,585)						(11,227)
Deferred tax liabilities			$	(22,591)					$	(24,966)
Net deferred tax liabilities			$	(85)					$	(139)

Schedule of Unrecognized Tax Benefits

The following table summarizes the gross amounts of unrecognized tax benefits (in thousands):

			2023						2022
Balance as of January 1,			$	11,539					$	7,382
Additions related to prior period tax positions			230						1,564
Reductions related to prior period tax positions			—						—
Additions related to current period tax positions			2,984						2,593
Balance as of December 31,			$	14,753					$	11,539

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months.

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