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Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Operating activities |  |
Net loss | $ (457,700) | $ (404,573)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 3,024 | 2,559
Amortization of intangible assets | 2,526 | 2,526
Stock-based compensation expense | 44,736 | 34,802
Amortization of debt issuance costs | 3,651 | 3,728
Paid-in-kind interest capitalized | 12,571 | 11,201
Royalty financing non-cash interest expense | 9,715 | 3,846
Accretion of discount on marketable securities, net | (1,963) | 0
Finance lease amortization expense | 1,356 | 1,356
Non-cash operating lease expense | 1,611 | 7,299
Change in fair value of deferred and contingent consideration liabilities | 91,800 | 4,000
Change in fair value of interest rate swap | (2,746) | 349
Changes in operating assets and liabilities: |  |
Accounts receivable | (1,080) | (2,291)
Inventory | (8,353) | (8,081)
Prepaid expenses and other current assets | (17,823) | (155)
Other assets | 15,699 | (7,458)
Accounts payable and accrued liabilities | 2,737 | 224
Other liabilities | (6,748) | (5,158)
Net cash used in operating activities | (306,987) | (269,095)
Investing activities |  |
Purchase of fixed assets | (11,462) | (8,281)
Purchase of marketable securities | 0 | (292,690)
Cash acquired in asset acquisition | 0 | 3,417
Maturities of marketable securities | 300,000 | 65,000
Net cash provided by (used in) investing activities | 288,538 | (232,554)
Financing activities |  |
Proceeds from exercise of stock options and ESPP | 72,623 | 8,422
Proceeds from issuance of common stock, net | 713,158 | 38,014
Payments of finance lease principal | (1,266) | (1,291)
Payment of debt issuance costs | 0 | (1,218)
Net cash provided by financing activities | 784,515 | 43,927
Effect of exchange rates on cash and cash equivalents | (1,641) | (3,432)
Net increase (decrease) in cash and cash equivalents | 764,425 | (461,154)
Cash and cash equivalents at beginning of period | 482,374 | 1,074,036
Cash and cash equivalents at end of period | 1,246,799 | 612,882
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 16,695 | 19,491
Cash paid for income taxes | 1,562 | 1,362
Vertuis Bio, Inc. |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Vertuis acquisition | 0 | 10,250
Adrestia acquisition | 0 | 10,250
Adrestia Therapeutics Ltd |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Vertuis acquisition | 0 | 76,481
Adrestia acquisition | $ 0 | $ 76,481

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