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Consolidated Statements of Comprehensive Loss (unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Jun. 30, 2024
Jun. 30, 2023
Statement of Comprehensive Income [Abstract]        
Revenue from Contract with Customer, Product and Service [Extensible List] Product [Member] Product [Member] Product [Member] Product [Member]
Product revenues, net $ 90,340 $ 77,229 $ 165,840 $ 142,443
Operating expenses:        
Cost, Product and Service [Extensible List] Product [Member] Product [Member] Product [Member] Product [Member]
Cost of product revenues (excluding amortization of intangible assets) $ 20,964 $ 16,594 $ 38,421 $ 30,424
Research and development 146,748 196,969 267,831 324,834
Selling, general and administrative 106,569 84,431 199,671 164,345
Amortization of intangible assets 1,263 1,263 2,526 2,526
Change in fair value of deferred and contingent consideration liabilities 103,700 13,500 91,800 4,000
Total operating expenses 379,244 312,757 600,249 526,129
Operating loss (288,904) (235,528) (434,409) (383,686)
Investment income 10,285 11,172 19,068 21,696
Interest expense (21,267) (20,619) (42,309) (40,622)
Change in fair value of interest rate swap 384 1,184 2,746 (349)
Other expense, net (269) (488) (1,369) (599)
Loss before income taxes (299,771) (244,279) (456,273) (403,560)
Provision for income taxes 838 530 1,427 1,013
Net loss $ (300,609) $ (244,809) $ (457,700) $ (404,573)
Basic net loss per share (in dollars per share) $ (1.94) $ (1.78) $ (3.02) $ (2.95)
Diluted net loss per share (in dollars per share) $ (1.94) $ (1.78) $ (3.02) $ (2.95)
Weighted average basic common shares outstanding (in shares) 154,702 137,553 151,579 136,957
Weighted average diluted common shares outstanding (in shares) 154,702 137,553 151,579 136,957
Net loss, basic $ (300,609) $ (244,809) $ (457,700) $ (404,573)
Net loss, diluted (300,609) (244,809) (457,700) (404,573)
Other comprehensive income (loss):        
Foreign currency translation losses (1,194) (2,202) (2,049) (2,373)
Unrealized (loss) gain on marketable securities 0 (132) (36) 366
Total comprehensive loss $ (301,803) $ (247,143) $ (459,785) $ (406,580)