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Fair Value Measurements - Narrative (Details)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended
Aug. 04, 2021
shares
Aug. 31, 2023
shares
Oct. 31, 2022
USD ($)
Aug. 31, 2022
shares
Aug. 31, 2021
sale
shares
Sep. 30, 2023
shares
Sep. 30, 2022
shares
Dec. 31, 2021
shares
Jun. 30, 2024
USD ($)
Jun. 30, 2023
USD ($)
Sep. 01, 2025
Dec. 31, 2023
USD ($)
Oct. 01, 2022
May 31, 2021
USD ($)
Jan. 31, 2018
USD ($)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Maturities of marketable securities                 $ 300,000 $ 65,000          
Deferred consideration                 12,400            
Non-current contingent consideration                 101,500     $ 84,600      
Accounts Payable and Accrued Liabilities                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Deferred consideration                 $ 12,400            
0.75% Convertible Senior Notes Due 2028 | Convertible notes                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Interest rate (as a percent)                 0.75%            
Convertible senior notes                           $ 371,600  
Original Term Loan balance                           $ 575,000  
1.75% Convertible Senior Notes Due 2025 | Convertible notes                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Interest rate (as a percent)                 1.75%            
Convertible senior notes                             $ 309,100
Original Term Loan balance                             $ 450,000
Royalty Agreements | ARIKAYCE Global Net Sales                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Royalty percentage                         4.00%    
Royalty Agreements | Brensocatib Global Net Sales                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Royalty percentage     75.00%                        
Royalty Agreements | Forecast | ARIKAYCE Global Net Sales                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Royalty percentage                     4.50%        
Royalty Agreements | Secured Debt                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Proceeds from royalty financing     $ 150,000                        
Original Term Loan balance     150,000                        
Interest payments     $ 150,000                        
Probabilities of success                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Weighted average probability of success                 0.42            
Recurring Basis | Level 3 | Estimate of Fair Value Measurement                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Marketable securities                       0      
Deferred consideration                 $ 0     0      
Recurring Basis | Level 2 | Estimate of Fair Value Measurement                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Marketable securities                       0      
Deferred consideration                 12,400     $ 5,700      
Recurring Basis | Level 2 | 0.75% Convertible Senior Notes Due 2028 | Convertible notes | Estimate of Fair Value Measurement                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Convertible senior notes                 1,200,000            
Recurring Basis | Level 2 | 1.75% Convertible Senior Notes Due 2025 | Convertible notes | Estimate of Fair Value Measurement                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Convertible senior notes                 384,500            
Motus                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Shares issued in acquisition (in shares) | shares 2,889,367 177,203   171,427   177,203 171,427 2,889,367              
Shares issued upon milestone achievements (in shares) | shares         5,348,572                    
Motus | Development and regulatory milestones                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Proceeds of sale of priority review voucher obligated to pay to equity holders, percentage         50.00%                    
Average sales prices of publicly disclosed priority review voucher sales obligated to pay equity holders, percentage         50.00%                    
Number of publicly disclosed sales used to determine average sales price owed to equity holders | sale         3                    
Motus | First Anniversary of Closing Date                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Shares issued in acquisition (in shares) | shares         184,433                    
Motus | Second Anniversary of Closing Date                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Shares issued in acquisition (in shares) | shares         184,433                    
Motus | Third Anniversary of Closing Date                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Shares issued in acquisition (in shares) | shares         184,433                    
Motus | Level 3                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Current contingent consideration                 101,500            
Non-current contingent consideration                 $ 68,200            
AlgaeneX                              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                              
Shares issued upon milestone achievements (in shares) | shares 368,867