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v3.26.1

Segment Reporting (Tables) | 6 Months Ended
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Jun. 30, 2026
Segment Reporting [Abstract] |
Schedule of Segment Loss, Including Significant Segment Expenses | Segment loss, including significant segment expenses, for the three and six months ended June 30, 2026 and 2025 is as follows (in thousands):
|  |  | Three Months Ended June 30, |  | Six Months Ended June 30,
|  |  | 2026 |  | 2025 |  | 2026 |  | 2025
Product revenues, net |  | $ | 425,486 |  |  | $ | 107,415 |  |  | $ | 731,450 |  |  | $ | 200,238 |
Less: |  |  |  |  |  |  |  |
| Cost of product revenues (excluding amortization of intangible assets) |  | 67,212 |  |  | 28,075 |  |  | 114,632 |  |  | 49,353 |
| TPIP external R&D expenses |  | 38,935 |  |  | 20,649 |  |  | 76,276 |  |  | 29,802 |
| Brensocatib external R&D expenses |  | 13,829 |  |  | 33,560 |  |  | 32,313 |  |  | 54,221 |
| ARIKAYCE external R&D expenses |  | 6,228 |  |  | 11,003 |  |  | 14,850 |  |  | 23,124 |
| Other external R&D expenses |  | 48,836 |  |  | 28,445 |  |  | 81,514 |  |  | 56,528 |
| R&D compensation and benefit-related expenses |  | 69,080 |  |  | 56,389 |  |  | 141,220 |  |  | 109,947 |
| SG&A compensation and benefit-related expenses |  | 70,520 |  |  | 51,320 |  |  | 145,313 |  |  | 106,156 |
| Other segment items(a) |  | 207,425 |  |  | 127,650 |  |  | 417,913 |  |  | 247,345 |
| Depreciation |  | 3,179 |  |  | 2,484 |  |  | 6,113 |  |  | 4,367 |
| Amortization of intangible assets |  | 2,081 |  |  | 1,263 |  |  | 4,162 |  |  | 2,526 |
| Change in fair value of contingent consideration |  | (99,760) |  |  | 59,000 |  |  | (146,721) |  |  | 77,300 |
| Investment income |  | (10,979) |  |  | (13,225) |  |  | (23,019) |  |  | (27,131) |
| Interest expense |  | 20,273 |  |  | 21,245 |  |  | 40,355 |  |  | 42,814 |
| Provision for income taxes |  | 1,869 |  |  | 1,243 |  |  | 3,334 |  |  | 2,155 |
Segment net loss |  | $ | (13,242) |  |  | $ | (321,686) |  |  | $ | (176,805) |  |  | $ | (578,269) |
(a) Other segment items include stock-based compensation, professional fees, and facility-related expenses.

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- Definition Tabular disclosure of segment reporting. Includes, but is not limited to, reconciliation of reportable segment amount to corresponding consolidated total. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 31 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-31 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 34 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-34 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 32 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-32 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 Reference 5: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 26C -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-26C Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 26B -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-26B Reference 7: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 26A -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-26A Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 10: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 15 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-15 + Details
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