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v3.26.1

Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2026 | Jun. 30, 2025
Operating activities |  |
Net loss | $ (176,805) | $ (578,269)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 6,113 | 4,367
Amortization of intangible assets | 4,162 | 2,526
Stock-based compensation expense | 87,008 | 82,238
Amortization of debt issuance costs | 2,811 | 3,498
Royalty financing non-cash interest expense | 10,243 | 10,215
Accretion of discount on marketable securities, net | (11,977) | (15,910)
Finance lease amortization expense | 1,356 | 1,356
Non-cash operating lease expense | 1,386 | 1,574
Change in fair value of contingent consideration | (146,721) | 77,300
Changes in operating assets and liabilities: |  |
Accounts receivable | (75,350) | (781)
Inventory | (14,860) | (5,997)
Prepaid expenses and other current assets | (25,049) | (23,475)
Other assets | (7,587) | 12,515
Accounts payable and accrued liabilities | 34,945 | (35,832)
Other liabilities | (1,241) | (2,982)
Net cash used in operating activities | (311,566) | (467,657)
Investing activities |  |
Purchase of fixed assets | (9,739) | (13,554)
Payment of AZ milestone | (15,000) | 0
Purchase of marketable securities | (399,228) | (907,199)
Maturities of marketable securities | 714,000 | 1,229,000
Net cash provided by investing activities | 290,033 | 308,247
Financing activities |  |
Proceeds from exercise of stock options and ESPP | 58,319 | 66,669
Proceeds from issuance of common stock, net | 0 | 823,538
Payments of principal of 0.75% convertible senior notes due 2028 | 0 | (1,965)
Payments of finance lease principal | (1,626) | (1,438)
Net cash provided by financing activities | 56,693 | 886,804
Effect of exchange rates on cash and cash equivalents | (840) | 1,900
Net increase in cash and cash equivalents | 34,320 | 729,294
Cash and cash equivalents at beginning of period | 510,445 | 555,030
Cash and cash equivalents at end of period | 544,765 | 1,284,324
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 26,391 | 26,391
Cash paid for income taxes | $ 3,636 | $ 2,853

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