<SEC-DOCUMENT>0001567619-22-001987.txt : 20220128
<SEC-HEADER>0001567619-22-001987.hdr.sgml : 20220128
<ACCEPTANCE-DATETIME>20220128164212
ACCESSION NUMBER:		0001567619-22-001987
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220126
FILED AS OF DATE:		20220128
DATE AS OF CHANGE:		20220128

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Brooks Christopher T
		CENTRAL INDEX KEY:			0001727447

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19582
		FILM NUMBER:		22569527

	MAIL ADDRESS:	
		STREET 1:		500 OLD DOMINION WAY
		CITY:			THOMASVILLE
		STATE:			NC
		ZIP:			27360

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OLD DOMINION FREIGHT LINE, INC.
		CENTRAL INDEX KEY:			0000878927
		STANDARD INDUSTRIAL CLASSIFICATION:	TRUCKING (NO LOCAL) [4213]
		IRS NUMBER:				560751714
		STATE OF INCORPORATION:			VA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		500 OLD DOMINION WAY
		CITY:			THOMASVILLE
		STATE:			NC
		ZIP:			27360
		BUSINESS PHONE:		3368895000

	MAIL ADDRESS:	
		STREET 1:		500 OLD DOMINION WAY
		CITY:			THOMASVILLE
		STATE:			NC
		ZIP:			27360

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OLD DOMINION FREIGHT LINE INC/VA
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-01-26</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000878927</issuerCik>
        <issuerName>OLD DOMINION FREIGHT LINE, INC.</issuerName>
        <issuerTradingSymbol>ODFL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001727447</rptOwnerCik>
            <rptOwnerName>Brooks Christopher T</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O OLD DOMINION FREIGHT LINE, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>500 OLD DOMINION WAY</rptOwnerStreet2>
            <rptOwnerCity>THOMASVILLE</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27360</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP - Human Resources &amp; Safety</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-01-26</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2258</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>16931</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>381</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By 401(k) plan</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares represent a performance-based restricted stock unit award granted on February 11, 2021. On January 26, 2022, the Compensation Committee of the Company's Board of Directors certified performance at the maximum level with respect to the 2021 performance period.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Christopher T. Brooks</signatureName>
        <signatureDate>2022-01-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
