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Income Taxes - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Reconciliation Of Income Taxes [Line Items]
Federal statutory income tax rate	21.00%	35.00%	35.00%
Increase in valuation allowance	$ 36,100,000	$ 5,500,000	$ 16,500,000
Valuation allowance changes, description	The Company does not expect any significant changes in its valuation allowance positions within the next 12 months.
Federal net operating loss carryforwards	$ 479,500,000
State net operating loss carryforwards	301,400,000
Research and development credits	$ 11,154,000	$ 9,402,000
Minimum percentage chances of tax benefit to be realized on examination	50.00%
Unrecognized tax benefits affect the Company's effective tax rate	$ 0
Interest or penalties recorded	$ 0
Expected significant change in unrecognized tax benefits, description	The Company does not expect any significant change in its unrecognized tax benefits within the next 12 months
Federal [Member]
Reconciliation Of Income Taxes [Line Items]
Net operating loss, carryforwards, period	20 years
Net operating loss carryforwards, expiration year	Dec. 31, 2037
Interest expense carryforward	$ 10,000,000
Research and development credits	$ 6,800,000
Research and development credit carryforwards, expiration year	Dec. 31, 2038
State [Member]
Reconciliation Of Income Taxes [Line Items]
Net operating loss carryforwards, expiration year	Dec. 31, 2038
Research and development credits	$ 3,500,000
Research and development credit carryforwards, expiration year	Dec. 31, 2033
Investments credits	$ 932,000
Ireland [Member] | Earliest Tax Year [Member]
Reconciliation Of Income Taxes [Line Items]
Open tax year	2014
Ireland [Member] | Latest Tax Year [Member]
Reconciliation Of Income Taxes [Line Items]
Open tax year	2018

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