v2.4.0.6

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2011

Income Taxes [Abstract]

Deferred Tax Assets and Liabilities

		December 31,
		2011				2010
Deferred tax assets:
Net operating loss carryforwards		$	106,456			$	89,069
Capitalized research and development expenses			10,532				15,743
Tax credits			5,021				3,975
Share-based compensation			9,798				6,750
Fixed and intangible assets			960				1,397
Other, net			1,885				1,329
Total gross deferred tax assets			134,652				118,263
Less: valuation allowance			(134,652	)			(118,263	)
Net deferred tax assets			0				0

Reconciliation Between Effective Tax Rate And Statutory Rate

		December 31,
		2011				2010				2009
Income taxes (benefit) at statutory rates			35.00	%			35.00	%			35.00	%
State income tax, net of federal benefit			2.45	%			3.46	%			3.16	%
Permanent items			(2.79	)%			(2.68	)%			(2.20	)%
Research and development credits			3.93	%			2.51	%			2.32	%
Tax attribute carryover limitation			0	%			0	%			(4.89	)%
Other			(2.02	)%			(0.36	)%			1.09	%
Change in valuation allowance			(36.65	)%			(37.88	)%			(34.45	)%
			(0.07	)%			0.06	%			0.03	%

Summary of Income Tax Contingencies [Table Text Block]

Balance at January 1, 2009		$	3,077
Adjustments related to prior year tax positions			51
Increases related to current year tax positions			604
Decreases due to IRC Section 382 limitation			(837	)
Balance at December 31, 2009			2,895
Increases related to current year tax positions			677
Balance at December 31, 2010			3,572
Increases related to current year tax positions			857
Balance at December 31, 2011		$	4,429

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

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Tabular disclosure of tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities (i.e., uncertain tax positions) and other types of income tax contingencies, including: (1) the policy on classification of interest and penalties; (2) a tabular reconciliation of the total amounts of unrecognized tax benefits at the beginning and end of the period; the total amount(s) of: (3) unrecognized tax benefits that, if recognized, would affect the effective tax rate, and (4) interest and penalties recognized in each of the income statement and balance sheet; (5) for positions for which it is reasonably possible that the total amounts unrecognized will significantly change within 12 months of the reporting date the: (i) nature of the uncertainty, (ii) nature of the event that could occur that would cause the change, and (iii) an estimate of the range of the reasonably possible change or a statement that an estimate of the range cannot be made; and (6) a description of tax years that remain subject to examination by major tax jurisdictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.



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