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Development and Other Agreements - Additional Information (Detail) - Google Life Sciences LLC - Collaborative Arrangement - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Sep. 30, 2015 | Sep. 30, 2018 | Dec. 31, 2015 | Aug. 10, 2015
Development Agreements [Line Items] |  |  |  |
Sales revenue, goods, net |  | $ 750,000,000 |  |
Commitment amount, royalty eligible sales threshold not achieved |  |  |  | $ 0
Collaborative Arrangement, Initial Payment |  |  |  |
Development Agreements [Line Items] |  |  |  |
Upfront fee |  |  |  | $ 35,000,000
Shares, issued | 404,591 |  |  |
Share Price |  |  |  | $ 90.29
Collaborative Arrangement, Milestone Payments |  |  |  |
Development Agreements [Line Items] |  |  |  |
Development & regulatory milestone payments |  |  |  | $ 65,000,000
Research and Development Expense | Collaborative Arrangement, Initial Payment |  |  |  |
Development Agreements [Line Items] |  |  |  |
R&D expense through issuance of common stock |  |  | $ 36,500,000 |

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