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Income Taxes - Reconciliation Between Effective Tax Rate and Statutory Rate (Detail) - USD ($) $ in Millions | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Effective Income Tax Rate Reconciliation, Amount [Abstract] |  |  |  |
Income taxes at statutory rates |  | $ (26.6) | $ (17.0) | $ (22.7)
State income tax, net of federal benefit |  | (5.5) | (0.7) | 1.2
Permanent items |  | 1.3 | 0.7 | 0.8
Research and development credits |  | (11.7) | (13.3) | (11.7)
Foreign rate differential |  | 3.7 | 5.4 | 4.5
Stock and officers compensation |  | (5.1) | (10.4) | 4.0
Rate change |  | 0.0 | (0.1) | (0.1)
Unrecognized tax benefits |  | 0.0 | (15.4) | 27.7
Cumulative Effect of New Accounting Principle in Period of Adoption |  | (13.3) | 0.0 | 0.0
Impact of Tax Cuts and Jobs Act of 2017 |  | (0.4) | 105.7 | 0.0
Other |  | 1.3 | (2.2) | 0.0
Change in valuation allowance |  | 56.9 | (51.1) | (3.0)
Income taxes at effective rates | $ 1.6 | $ 0.6 | $ 1.6 | $ 0.7

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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Subparagraph (h) -URI http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(h)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 20 -Section 45 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109238882&loc=d3e38679-109324 + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 45 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=84176650&loc=d3e32123-109318 + Details
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