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Income Taxes - Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Millions | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 162.0 | $ 188.7
Capitalized research and development expenses | 62.1 | 8.4
Tax credits | 59.0 | 47.8
Share-based compensation | 12.5 | 13.8
Fixed and intangible assets | 16.0 | 0.4
Accrued liabilities and reserves | 22.5 | 20.5
Total gross deferred tax assets | 334.1 | 279.6
Less: valuation allowance | (330.1) | (263.5)
Total net deferred tax assets | 4.0 | 16.1
Deferred tax liabilities: |  |
Fixed assets and acquired intangibles assets | (3.8) | (0.1)
Convertible debt discount | (0.1) | (15.9)
Total deferred tax liabilities | (3.9) | (16.0)
Net deferred tax assets (liabilities) | $ 0.1 | $ 0.1

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