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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

Income (loss) before income taxes subject to taxes in the following jurisdictions is as follows:

	Twelve Months Ended   December 31, 2018
(In millions)	2018				2017				2016
United States	$	(28.3	)		$	12.4			$	(44.4	)
Outside of the United States	(98.2		)		(61.0		)		(20.5		)
Total	$	(126.5	)		$	(48.6	)		$	(64.9	)

Schedule of Components of Income Tax Expense (Benefit)

Significant components of the provision for income taxes are as follows:

	Twelve Months Ended   December 31, 2018
(In millions)	2018				2017				2016
Current:
Federal	$	—			$	—			$	—
State	2.7				0.1				0.1
Foreign	0.1				1.5				0.8
Total current income taxes	2.8				1.6				0.9
Deferred:
Federal	(1.7		)		—				(0.1		)
State	(0.5		)		—				—
Foreign	—				—				(0.1		)
Total deferred income taxes	(2.2		)		—				(0.2		)
Total	$	0.6			$	1.6			$	0.7

Deferred Tax Assets and Liabilities

	December 31,
(In millions)	2018				2017
Deferred tax assets:
Net operating loss carryforwards	$	162.0			$	188.7
Capitalized research and development expenses	62.1				8.4
Tax credits	59.0				47.8
Share-based compensation	12.5				13.8
Fixed and intangible assets	16.0				0.4
Accrued liabilities and reserves	22.5				20.5
Total gross deferred tax assets	334.1				279.6
Less: valuation allowance	(330.1		)		(263.5		)
Total net deferred tax assets	4.0				16.1
Deferred tax liabilities:
Fixed assets and acquired intangibles assets	(3.8		)		(0.1		)
Convertible debt discount	(0.1		)		(15.9		)
Total deferred tax liabilities	(3.9		)		(16.0		)
Net deferred tax assets (liabilities)	$	0.1			$	0.1

Reconciliation Between Effective Tax Rate and Statutory Rate

The reconciliation between our effective tax rate on income (loss) from continuing operations and the statutory rate is as follows:

	Twelve Months Ended   December 31, 2018
(In millions)	2018				2017				2016
Income taxes at statutory rates	$	(26.6	)		$	(17.0	)		$	(22.7	)
State income tax, net of federal benefit	(5.5		)		(0.7		)		1.2
Permanent items	1.3				0.7				0.8
Research and development credits	(11.7		)		(13.3		)		(11.7		)
Foreign rate differential	3.7				5.4				4.5
Stock and officers compensation	(5.1		)		(10.4		)		4.0
Rate change	—				(0.1		)		(0.1		)
Unrecognized tax benefits	—				(15.4		)		27.7
Impact of adoption of ASU 2016-16	(13.3		)		—				—
Impact of Tax Cuts and Jobs Act of 2017	(0.4		)		105.7				—
Other	1.3				(2.2		)		—
Change in valuation allowance	56.9				(51.1		)		(3.0		)
Income taxes at effective rates	$	0.6			$	1.6			$	0.7

Summary of Unrecognized Tax Benefits

The following table summarizes the activity related to our gross unrecognized tax benefits:

(In millions)
Balance at January 1, 2016	$	15.6
Decreases related to prior year tax positions	(8.4		)
Increases related to current year tax positions	32.6
Balance at December 31, 2016	39.8
Decreases related to prior year tax positions	(14.9		)
Increases related to current year tax positions	3.3
Decrease related to Tax Cuts and Jobs Act of 2017	(5.4		)
Balance at December 31, 2017	22.8
Decreases related to prior year tax positions	(0.3		)
Increases related to current year tax positions	3.4
Balance at December 31, 2018	$	25.9

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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