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Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income Statement [Abstract]
Revenue	$ 1,031.6	$ 718.5	$ 573.3
Cost of sales	367.7	226.4	194.9
Gross profit	663.9	492.1	378.4
Operating expenses
Research and development	199.7	185.4	156.1
Collaborative research and development fee	217.7	0.0	0.0
Selling, general and administrative	432.8	349.2	286.2
Total operating expenses	850.2	534.6	442.3
Operating loss	(186.3)	(42.5)	(63.9)
Interest expense	(22.7)	(12.8)	(0.7)
Income from equity investments	80.1	0.0	0.0
Interest and other income (expense), net	2.4	6.7	(0.3)
Loss before income taxes	(126.5)	(48.6)	(64.9)
Income tax expense	0.6	1.6	0.7
Net loss	$ (127.1)	$ (50.2)	$ (65.6)
Basic and diluted net loss per share (in USD per share)	$ (1.44)	$ (0.58)	$ (0.78)
Shares used to compute basic and diluted net loss per share (in shares)	88.2	86.3	83.6

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