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Consolidated Statements of Cash Flows
$ in Millions
 12 Months Ended
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Operating activities      
Net loss $ (127.1) $ (50.2) $ (65.6)
Adjustments to reconcile net loss to cash provided by operating activities:      
Depreciation and amortization 29.1 16.1 15.0
Share-based compensation 101.9 106.2 110.8
Non-cash interest expense 17.9 9.4 0.1
Non-cash collaborative research and development fee through issuance of common stock 217.7 0.0 0.0
Unrealized income on equity investment (36.0) 0.0 0.0
Less: Net gains recognized during the period on equity securities sold during the period (44.1) 0.0 0.0
Other non-cash income and expenses 4.7 7.9 2.2
Changes in operating assets and liabilities:      
Accounts receivable, net (93.2) (31.8) (27.2)
Inventory (25.5) 0.4 (9.8)
Prepaid and other assets (3.0) (6.7) (3.9)
Accounts payable and accrued liabilities 56.2 21.1 21.1
Accrued payroll and related expenses 23.8 14.8 8.5
Deferred revenue, deferred rent and other liabilities 0.8 4.8 5.0
Net cash provided by operating activities 123.2 92.0 56.2
Investing activities      
Purchase of marketable securities (452.5) (171.8) (39.2)
Proceeds from sale and maturity of marketable securities 392.1 93.4 38.7
Purchase of other equity investments (1.0) 0.0 0.0
Purchase of property and equipment (67.1) (66.0) (55.7)
Acquisitions, net of cash acquired (11.3) 0.0 0.3
Net cash used in investing activities (139.8) (144.4) (55.9)
Financing activities      
Net proceeds from issuance of common stock 10.8 10.1 10.4
Payments for Repurchase of Common Stock (100.0) 0.0 0.0
Proceeds from issuance of convertible debt, net of issuance costs 836.6 389.0 0.0
Proceeds from sale of warrants 183.8 0.0 0.0
Purchase of convertible note hedge (218.9) 0.0 0.0
Proceeds from short-term borrowings 0.0 75.0 0.0
Repayment of short-term borrowings 0.0 (75.0) 0.0
Other financing activities (1.9) 0.0 (2.3)
Net cash provided by financing activities 710.4 399.1 8.1
Effect of exchange rate changes on cash, cash equivalents and restricted cash 1.8 0.3 0.0
Increase in cash, cash equivalents and restricted cash 695.6 347.0 8.4
Cash, cash equivalents and restricted cash, beginning of period 1,137.1 441.5 94.5
Cash, cash equivalents and restricted cash, end of period 441.5 94.5 86.1
Reconciliation of cash, cash equivalents and restricted cash, end of period:      
Cash and cash equivalents 1,137.0 441.5 94.5
Restricted cash 0.1 0.0 0.0
Supplemental disclosure of non-cash investing and financing transactions:      
Issuance of common stock in connection with acquisition 0.0 0.0 7.2
Assets acquired and financing obligation under build-to-suit leasing arrangement 0.0 0.0 6.0
Acquisition of property and equipment included in accounts payable and accrued liabilities 10.8 6.3 10.5
Supplemental cash flow information:      
Cash paid during the year for interest 3.6 2.4 0.1
Cash paid during the year for income taxes $ 2.3 $ 1.4 $ 0.1