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Consolidated Statements of Stockholders' Equity - USD ($) $ in Millions | Total | Senior convertible notes due 2022 | Senior convertible notes due 2023 | Common Stock | Additional Paid-In Capital | Additional Paid-In Capital Senior convertible notes due 2022 | Additional Paid-In Capital Senior convertible notes due 2023 | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Treasury Stock
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at beginning of period (shares) at Dec. 31, 2016 |  |  |  | 84,600,000 |  |  |  |  |  |
Balance at beginning of period at Dec. 31, 2016 | $ 283.8 |  |  | $ 0.1 | $ 905.7 |  |  | $ (1.0) | $ (621.0) | $ 0.0
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Issuance of common stock under equity incentive plans (shares) |  |  |  | 2,300,000 |  |  |  |  |  |
Issuance of common stock under equity incentive plans | 2.7 |  |  |  | 2.7 |  |  |  |  |
Issuance of common stock for Employee Stock Purchase Plan (shares) |  |  |  | 100,000 |  |  |  |  |  |
Issuance of common stock for Employee Stock Purchase Plan | 7.4 |  |  |  | 7.4 |  |  |  |  |
Share-based compensation expense | 106.7 |  |  |  | 106.7 |  |  |  |  |
Equity component of convertible note issuance, net of issuance costs |  | $ 70.6 |  |  |  | $ 70.6 |  |  |  |
Cumulative effect of adoption of new accounting pronouncement | Accounting Standards Update 2016-09 |  |  |  |  | 0.6 |  |  |  | (0.6) |
Net income (loss) | (50.2) |  |  |  |  |  |  |  | (50.2) |
Other comprehensive income (loss) | (1.6) |  |  |  |  |  |  | (1.6) |  |
Balance at end of period (shares) at Dec. 31, 2017 |  |  |  | 87,000,000.0 |  |  |  |  |  |
Balance at end of period at Dec. 31, 2017 | 419.4 |  |  | $ 0.1 | 1,093.7 |  |  | (2.6) | (671.8) | 0.0
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Issuance of common stock under equity incentive plans (shares) |  |  |  | 1,800,000 |  |  |  |  |  |
Issuance of common stock under equity incentive plans | 1.9 |  |  |  | 1.9 |  |  |  |  |
Issuance of common stock for Employee Stock Purchase Plan (shares) |  |  |  | 200,000 |  |  |  |  |  |
Issuance of common stock for Employee Stock Purchase Plan | 8.9 |  |  |  | 8.9 |  |  |  |  |
Share-based compensation expense | 101.9 |  |  |  | 101.9 |  |  |  |  |
Equity component of convertible note issuance, net of issuance costs | (218.9) |  | $ 171.6 |  | (218.9) |  | $ 171.6 |  |  |
Issuance of common stock for collaborative research and development fee (shares) |  |  |  | 1,800,000 |  |  |  |  |  |
Issuance of common stock for collaborative research and development fee | 217.7 |  |  |  | 217.7 |  |  |  |  |
Sale of warrants | $ 183.8 |  |  |  | 183.8 |  |  |  |  |
Purchases of treasury stock (shares) | (800,000) |  |  | (800,000) |  |  |  |  |  |
Purchases of treasury stock | $ (100.0) |  |  |  |  |  |  |  |  | (100.0)
Net income (loss) | (127.1) |  |  |  |  |  |  |  | (127.1) |
Other comprehensive income (loss) | 4.1 |  |  |  |  |  |  | 4.1 |  |
Balance at end of period (shares) at Dec. 31, 2018 |  |  |  | 90,000,000.0 |  |  |  |  |  |
Balance at end of period at Dec. 31, 2018 | 663.3 |  |  | $ 0.1 | 1,560.6 |  |  | 1.5 | (798.9) | (100.0)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Issuance of common stock under equity incentive plans (shares) |  |  |  | 1,400,000 |  |  |  |  |  |
Issuance of common stock under equity incentive plans | 0.3 |  |  |  | 0.3 |  |  |  |  |
Issuance of common stock for Employee Stock Purchase Plan (shares) |  |  |  | 200,000 |  |  |  |  |  |
Issuance of common stock for Employee Stock Purchase Plan | 11.6 |  |  |  | 11.6 |  |  |  |  |
Share-based compensation expense | 102.7 |  |  |  | 102.7 |  |  |  |  |
Cumulative effect of adoption of new accounting pronouncement | Accounting Standards Update 2016-02 | $ 2.1 |  |  |  |  |  |  |  | 2.1 |
Purchases of treasury stock (shares) | 0 |  |  |  |  |  |  |  |  |
Realization of tax benefit related to 2023 Note Hedge | $ 0.7 |  |  |  | 0.7 |  |  |  |  |
Net income (loss) | 101.1 |  |  |  |  |  |  |  | 101.1 |
Other comprehensive income (loss) | 0.8 |  |  |  |  |  |  | 0.8 |  |
Balance at end of period (shares) at Dec. 31, 2019 |  |  |  | 91,600,000 |  |  |  |  |  |
Balance at end of period at Dec. 31, 2019 | $ 882.6 |  |  | $ 0.1 | $ 1,675.9 |  |  | $ 2.3 | $ (695.7) | $ (100.0)

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