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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2019 | Dec. 31, 2018
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 127.4 | $ 162.0
Capitalized research and development expenses | 57.1 | 62.1
Tax credits | 78.6 | 59.0
Share-based compensation | 10.9 | 12.5
Fixed and intangible assets | 14.0 | 16.0
Accrued liabilities and reserves | 62.0 | 22.5
Convertible Debt | 1.7 | 0.0
Total gross deferred tax assets | 351.7 | 334.1
Less: valuation allowance | (332.2) | (330.1)
Total net deferred tax assets | 19.5 | 4.0
Deferred tax liabilities: |  |
Fixed assets and acquired intangibles assets | (19.6) | (3.8)
Convertible debt discount | 0.0 | (0.1)
Total deferred tax liabilities | (19.6) | (3.9)
Net deferred tax assets (liabilities) | $ (0.1) | $ 0.1

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