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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2019
Income Tax Disclosure [Abstract] |
Schedule of Income (Loss) before Income Taxes Subject to Taxes | Income (loss) before income taxes subject to taxes in the following jurisdictions is as follows:
| Twelve Months Ended December 31,
(In millions) | 2019 |  | 2018 |  | 2017
United States | $ | 119.1 |  |  | $ | (28.3 | ) |  | $ | 12.4 |
Outside of the United States | (14.9 | ) |  | (98.2 | ) |  | (61.0 | )
Total | $ | 104.2 |  |  | $ | (126.5 | ) |  | $ | (48.6 | )
Schedule of Components of Income Tax Expense (Benefit) | Significant components of the provision for income taxes are as follows:
| Twelve Months Ended December 31, 2019
(In millions) | 2019 |  | 2018 |  | 2017
Current: |  |  |  |  |
Federal | $ | — |  |  | $ | — |  |  | $ | — |
State | 1.0 |  |  | 2.7 |  |  | 0.1 |
Foreign | 1.9 |  |  | 0.1 |  |  | 1.5 |
Total current income taxes | 2.9 |  |  | 2.8 |  |  | 1.6 |
Deferred: |  |  |  |  |
Federal | — |  |  | (1.7 | ) |  | — |
State | — |  |  | (0.5 | ) |  | — |
Foreign | 0.2 |  |  | — |  |  | — |
Total deferred income taxes | 0.2 |  |  | (2.2 | ) |  | — |
Total | $ | 3.1 |  |  | $ | 0.6 |  |  | $ | 1.6 |
Schedule of Deferred Tax Assets and Liabilities | Significant components of our deferred tax assets as of December 31, 2019 and 2018 are shown below. A valuation allowance of approximately $332.2 million has been established as of December 31, 2019 to offset the deferred tax assets, as realization of such assets is uncertain. We maintain a deferred tax liability related to indefinite-lived intangible assets that is not netted against the deferred tax assets. Reversal of the taxable temporary difference for these intangible assets cannot serve as a source of income for realization of the deferred tax assets because the deferred tax liability will not reverse until the intangible assets are sold or written down due to impairment.
| December 31,
(In millions) | 2019 |  | 2018
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ | 127.4 |  |  | $ | 162.0 |
Capitalized research and development expenses | 57.1 |  |  | 62.1 |
Tax credits | 78.6 |  |  | 59.0 |
Share-based compensation | 10.9 |  |  | 12.5 |
Fixed and intangible assets | 14.0 |  |  | 16.0 |
Accrued liabilities and reserves | 62.0 |  |  | 22.5 |
Convertible Debt | 1.7 |  |  | — |
Total gross deferred tax assets | 351.7 |  |  | 334.1 |
Less: valuation allowance | (332.2 | ) |  | (330.1 | )
Total net deferred tax assets | 19.5 |  |  | 4.0 |
Deferred tax liabilities: |  |  |
Fixed assets and acquired intangibles assets | (19.6 | ) |  | (3.8 | )
Convertible debt discount | — |  |  | (0.1 | )
Total deferred tax liabilities | (19.6 | ) |  | (3.9 | )
Net deferred tax assets (liabilities) | $ | (0.1 | ) |  | $ | 0.1 |
Schedule of Reconciliation between Effective Tax Rate and Statutory Rate | The reconciliation between our effective tax rate on income (loss) from continuing operations and the statutory rate is as follows:
| Twelve Months Ended December 31,
(In millions) | 2019 |  | 2018 |  | 2017
Income taxes at statutory rates | $ | 21.9 |  |  | $ | (26.6 | ) |  | $ | (17.0 | )
State income tax, net of federal benefit | (2.3 | ) |  | (5.5 | ) |  | (0.7 | )
Permanent items | 1.0 |  |  | 1.3 |  |  | 0.7 |
Research and development credits | (10.8 | ) |  | (11.7 | ) |  | (13.3 | )
Foreign rate differential | 5.6 |  |  | 3.7 |  |  | 5.4 |
Stock and officers compensation | (14.7 | ) |  | (5.1 | ) |  | (10.4 | )
Rate change | — |  |  | — |  |  | (0.1 | )
Unrecognized tax benefits | — |  |  | — |  |  | (15.4 | )
Impact of adoption of ASU 2016-16 | — |  |  | (13.3 | ) |  | — |
Impact of Tax Cuts and Jobs Act of 2017 | — |  |  | (0.4 | ) |  | 105.7 |
Other | (1.0 | ) |  | 1.3 |  |  | (2.2 | )
Change in valuation allowance | 3.4 |  |  | 56.9 |  |  | (51.1 | )
Income taxes at effective rates | $ | 3.1 |  |  | $ | 0.6 |  |  | $ | 1.6 |
Schedule of Unrecognized Tax Benefits | The following table summarizes the activity related to our gross unrecognized tax benefits:
(In millions) |
Balance at January 1, 2017 | $ | 39.8 |
Decreases related to prior year tax positions | (14.9 | )
Increases related to current year tax positions | 3.3 |
Decrease related to Tax Cuts and Jobs Act of 2017 | (5.4 | )
Balance at December 31, 2017 | 22.8 |
Decreases related to prior year tax positions | (0.3 | )
Increases related to current year tax positions | 3.4 |
Balance at December 31, 2018 | 25.9 |
Decreases related to prior year tax positions | (0.9 | )
Increases related to current year tax positions | 4.5 |
Balance at December 31, 2019 | $ | 29.5 |

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- Definition Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15A -URI http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32718-109319 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32840-109319 + Details
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