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Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Operating activities      
Net income (loss) $ 101.1 $ (127.1) $ (50.2)
Adjustments to reconcile net income (loss) to cash provided by operating activities:      
Depreciation and amortization 48.7 29.1 16.1
Share-based compensation 102.7 101.9 106.2
Non-cash interest expense 49.6 17.9 9.4
Non-cash collaborative research and development fee through issuance of common stock 0.0 217.7 0.0
Unrealized gain on equity investment 0.0 (36.0) 0.0
Realized (gain) loss on equity investment 4.2 (44.1) 0.0
Other non-cash income and expenses 2.1 4.7 7.9
Changes in operating assets and liabilities:      
Accounts receivable, net (60.0) (93.2) (31.8)
Inventory (49.1) (25.5) 0.4
Prepaid and other assets (7.2) (3.0) (6.7)
Operating lease right-of-use assets and liabilities, net (2.4) 0.0 0.0
Accounts payable and accrued liabilities 109.0 56.2 21.1
Accrued payroll and related expenses 16.0 23.8 14.8
Deferred revenue, deferred rent and other liabilities (0.2) 0.8 4.8
Net cash provided by operating activities 314.5 123.2 92.0
Investing activities      
Purchase of marketable securities (2,030.4) (452.5) (171.8)
Proceeds from sale and maturity of marketable securities 1,196.4 392.1 93.4
Purchase of other equity investments (1.2) (1.0) 0.0
Purchase of property and equipment (180.0) (67.1) (66.0)
Acquisitions, net of cash acquired 0.0 (11.3) 0.0
Net cash used in investing activities (1,015.2) (139.8) (144.4)
Financing activities      
Net proceeds from issuance of common stock 11.9 10.8 10.1
Purchases of treasury stock 0.0 (100.0) 0.0
Proceeds from issuance of convertible debt, net of issuance costs 0.0 836.6 389.0
Proceeds from sale of warrants 0.0 183.8 0.0
Purchase of convertible note hedge 0.0 (218.9) 0.0
Proceeds from short-term borrowings 0.0 0.0 75.0
Repayment of short-term borrowings 0.0 0.0 (75.0)
Other financing activities (1.2) (1.9) 0.0
Net cash provided by financing activities 10.7 710.4 399.1
Effect of exchange rate changes on cash, cash equivalents and restricted cash (0.7) 1.8 0.3
Increase (decrease) in cash, cash equivalents and restricted cash (690.7) 695.6 347.0
Cash, cash equivalents and restricted cash, beginning of period 1,137.1 441.5 94.5
Cash, cash equivalents and restricted cash, end of period 446.4 1,137.1 441.5
Reconciliation of cash, cash equivalents and restricted cash, end of period:      
Total cash, cash equivalents and restricted cash 1,137.1 1,137.1 94.5
Supplemental disclosure of non-cash investing and financing transactions:      
Acquisition of property and equipment included in accounts payable and accrued liabilities 14.2 10.8 6.3
Supplemental cash flow information:      
Cash paid during the year for interest 10.4 3.6 2.4
Cash paid during the year for income taxes $ 4.8 $ 2.3 $ 1.4